Carlos Diéguez
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View article: An astrocytic AMPK clock drives circadian behaviour
An astrocytic AMPK clock drives circadian behaviour Open
Summary Circadian clocks coordinate behaviour and physiology with daily cycles of light and nutrient availability, yet how metabolic signals tune brain timing remains unclear. Astrocytes integrate metabolic and hormonal cues and sustain ce…
View article: JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism
JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism Open
Our data demonstrated for the first time that JNK1 in SF1 neurons is necessary for the regulation of hepatic lipid metabolism, cold adaptation and central T3 actions.
View article: Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin
Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin Open
Objective Despite growing evidence, the mechanisms connecting adipose tissue (AT) function to type 2 diabetes (T2DM) remain incompletely understood. A detailed analysis of AT transcriptomes could offer valuable insights into this relations…
View article: Correction: Hypothalamic GHRH
Correction: Hypothalamic GHRH Open
View article: Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia
Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia Open
View article: Hypothalamic GHRH
Hypothalamic GHRH Open
View article: Hunger games: a role for cAMP
Hunger games: a role for cAMP Open
View article: SF1-specific deletion of the energy sensor AMPKγ2 induces obesity
SF1-specific deletion of the energy sensor AMPKγ2 induces obesity Open
View article: GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells Open
The use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencing considerable interest. However, whether these compounds have a direct action on MASH is still under debate. This st…
View article: Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism
Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism Open
Background The microbiota is emerging as a key factor in the predisposition to insulin resistance and obesity. Objective To understand the interplay among gut microbiota and insulin sensitivity in multiple tissues. Design Integrative multi…
View article: Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice
Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice Open
View article: Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway
Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway Open
Background and Aims: Mitochondrial antiviral signaling protein (MAVS) is a critical regulator that activates the host’s innate immunity against RNA viruses, and its signaling pathway has been linked to the secretion of proinflammatory cyto…
View article: The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging
The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging Open
Purpose Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a). In rodents, LEAP-2 blunts ghrelin-induce…
View article: p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway
p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway Open
View article: Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance Open
View article: Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas Open
View article: Cluster analysis in gambling disorder based on sociodemographic, neuropsychological, and neuroendocrine features regulating energy homeostasis
Cluster analysis in gambling disorder based on sociodemographic, neuropsychological, and neuroendocrine features regulating energy homeostasis Open
To the best of our knowledge, this is the first study to identify well-differentiated GD clusters using neuropsychological and neuroendocrine features. Our findings reinforce the heterogeneous nature of the disorder and emphasize a role of…
View article: Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications
Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications Open
Background Data implicate overlaps in neurobiological pathways involved in appetite regulation and addictive disorders. Despite different neuroendocrine measures having been associated with both gambling disorder (GD) and food addiction (F…
View article: Downregulated adipose tissue expression of browning genes with increased environmental temperatures
Downregulated adipose tissue expression of browning genes with increased environmental temperatures Open
The main study has investigated how the outside temperature might impact on adipose tissue physiology and metabolic traits, in which different regions of the same country were compared. Table 1 shows sequences of the primers used. Table …
View article: Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism Open
View article: Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function
Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function Open
View article: Obesity wars: hypothalamic sEVs a new hope
Obesity wars: hypothalamic sEVs a new hope Open
View article: A longitudinal study of free leptin index in pre‐eclamptic pregnancies
A longitudinal study of free leptin index in pre‐eclamptic pregnancies Open
The ratio between circulating levels of leptin and soluble leptin receptor (sOB‐R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre‐eclamptic pre…
View article: p63 Controls Metabolic Activation of Hepatic Stellate Cells and Fibrosis via ACC1
p63 Controls Metabolic Activation of Hepatic Stellate Cells and Fibrosis via ACC1 Open
View article: Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study
Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study Open
Gambling disorder (GD) is a modestly prevalent and severe condition for which neurobiology is not yet fully understood. Although alterations in signals involved in energy homeostasis have been studied in substance use disorders, they have …
View article: Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice
Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice Open
Overall, this evidence indicates that specific modulation of hypothalamic AMPK using a sEV-based technology may be a suitable strategy against genetic forms of obesity, such as LEPR deficiency.
View article: Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis Open
Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone …
View article: Food addiction in Bulimia Nervosa: Analysis of body composition, psychological and problematic foods profile
Food addiction in Bulimia Nervosa: Analysis of body composition, psychological and problematic foods profile Open
Introduction Food Addiction (FA) has been related with eating disorders (ED), especially Bulimia Nervosa (BN). BN + FA may have different physical characteristics than patients with BN without the comorbidity, such as body mass index (BMI)…
View article: Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy
Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy Open
The Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) has emerged as an endogenous GHS-R antagonist and blunts the orexigenic action of ghrelin. This study aimed to determine the Ghrelin/LEAP-2 ratio in humans and rats during pregnancy. In …
View article: Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21 Open
Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, the effects of breastfeeding by the infant on the reprogramming of energy balance in…