Carlos J. Camacho
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View article: Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Author response: Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Author response: Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
View article: Cell-type-agnostic differential gene expression uncovers conserved principles of cellular regulation
Cell-type-agnostic differential gene expression uncovers conserved principles of cellular regulation Open
Cellular responses to perturbagens—including pharmacological compounds and genetic manipulations—remain incompletely characterized, as conventional approaches are constrained by cell-type-specific biases. Here, we derive consensus signatur…
View article: An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck Open
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, …
View article: Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Reviewer #2 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Reviewer #2 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Reviewer #1 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Reviewer #1 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Reviewer #3 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans
Reviewer #3 (Public Review): Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans Open
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conse…
View article: Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies Open
View article: Spinal Cord Elongation Enables Proportional Regulation of the Zebrafish Posterior Body
Spinal Cord Elongation Enables Proportional Regulation of the Zebrafish Posterior Body Open
Early embryos display a remarkable ability to regulate the patterning of tissues in response to changes in tissue size. However, it is not clear whether this ability continues into post-gastrulation stages upon cell commitment to distinct …
View article: Author Correction: A heterotypic assembly mechanism regulates CHIP E3 ligase activity
Author Correction: A heterotypic assembly mechanism regulates CHIP E3 ligase activity Open
View article: WITHDRAWN: Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
WITHDRAWN: Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies Open
View article: Favorable outcomes of NPM1mut AML patients are due to transcriptional inactivation of FOXM1, presenting a new target to overcome chemoresistance
Favorable outcomes of NPM1mut AML patients are due to transcriptional inactivation of FOXM1, presenting a new target to overcome chemoresistance Open
View article: Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein Open
The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which contains a docki…
View article: A rationally designed peptidomimetic modulator of CaV2.2 (N-type) voltage-gated calcium channels for chronic pain
A rationally designed peptidomimetic modulator of CaV2.2 (N-type) voltage-gated calcium channels for chronic pain Open
Background and Purpose Transmembrane Cav2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated pain targets. Clinical block of Cav2.2 (e.g., with Prialt) or indirect modulation (e.g., with gabapentinoid…
View article: Omicron and Alpha P680H block SARS-CoV2 spike protein from accessing cholinergic inflammatory pathway via α9-nAChR mitigating the risk of MIS-C
Omicron and Alpha P680H block SARS-CoV2 spike protein from accessing cholinergic inflammatory pathway via α9-nAChR mitigating the risk of MIS-C Open
Sequence homology between neurotoxins and the site encompassing the furin cleavage site 680 SPRRAR 685 in the spike protein (S) of CoV2 suggested that this site could interact with nicotinic acetylcholine receptors (nAChRs). Molecular dyna…
View article: Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity
Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity Open
The E3 ubiquitin ligases CHIP/CHN-1 and UFD-2 team up to accelerate ubiquitin chain formation. However, it remained largely unclear how the high processivity of this E3 set is achieved. Here we studied the molecular mechanism and function …
View article: Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells
Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells Open
View article: Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma
Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma Open
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View article: OTME-20. Chitinase-3-like-1(CHI3L1) Protein Complexes Regulate the immunosuppressive Microenvironment in Glioblastoma
OTME-20. Chitinase-3-like-1(CHI3L1) Protein Complexes Regulate the immunosuppressive Microenvironment in Glioblastoma Open
Glioblastoma (GBM) is the most common and highly malignant brain tumor in adults. Despite advances in multimodal treatment, GBM remains largely incurable. While immunotherapies have been highly effective in some types of cancer, the disapp…
View article: MAP2 is differentially phosphorylated in schizophrenia, altering its function
MAP2 is differentially phosphorylated in schizophrenia, altering its function Open
View article: Author Correction: De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
Author Correction: De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences Open
View article: A Resource of High-Quality Nanobodies for Drug Delivery
A Resource of High-Quality Nanobodies for Drug Delivery Open
View article: TAMI-50. CHITINASE-3-LIKE-1 PROTEIN BINDING COMPLEXES REGULATE IMMUNE SUPPRESSION IN GLIOBLASTOMA
TAMI-50. CHITINASE-3-LIKE-1 PROTEIN BINDING COMPLEXES REGULATE IMMUNE SUPPRESSION IN GLIOBLASTOMA Open
Glioblastoma (GBM), the most common and lethal brain tumor, remains incurable despite intensive multimodal treatment. While immunotherapies have been highly effective in some types of cancer, the disappointing results from clinical trials …
View article: A robust and versatile nanobody platform for drug delivery
A robust and versatile nanobody platform for drug delivery Open
Therapeutic and diagnostic efficacies of numerous small biomolecules and chemical compounds are hampered by the short half-lives. Here we report the development of a repertoire of diverse, high-affinity albumin-nanobodies (Nb HSA ) to faci…
View article: On the molecular mechanism of SARS-CoV-2 retention in the upper respiratory tract
On the molecular mechanism of SARS-CoV-2 retention in the upper respiratory tract Open
Cell surface receptor engagement is a critical aspect of viral infection. At low pH, binding of SARS-CoV and its ACE2 receptor has a tight interaction that catalyzes the fusion of the spike and endosomal membranes followed by genome releas…
View article: Loss of pH switch unique to SARS-CoV2 supports unfamiliar virus pathology
Loss of pH switch unique to SARS-CoV2 supports unfamiliar virus pathology Open
Cell surface receptor engagement is a critical aspect of viral infection. This paper compares the dynamics of virus-receptor interactions for SARS-CoV (CoV1) and CoV2. At low (endosomal) pH, the binding free energy landscape of CoV1 and Co…
View article: De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences Open
View article: Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations
Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations Open