Carlos M. Grilo
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View article: Cognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial
Cognitive‐Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge‐Eating Disorder: Secondary Outcomes of a Randomized Controlled Trial Open
Objective A 12‐week randomized controlled trial (RCT) found cognitive‐behavioral therapy (CBT), lisdexamfetamine (LDX), and combined CBT + LDX showed significant improvements in BED, with combined CBT + LDX being superior to the individual…
View article: Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations
Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations Open
Study Objectives Dim light melatonin onset (DLMO) is the best-established marker of central circadian phase and may contribute to unraveling the role of the circadian system in obesity. This study evaluated DLMO among individuals with obes…
View article: Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity
Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity Open
Objective To explore dietary‐restraint as a mediator of binge eating and weight‐loss outcomes within a randomized controlled trial comparing cognitive‐behavioral therapy (CBT) and behavioral weight loss (BWL) for binge‐eating disorder (BED…
View article: Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial
Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial Open
Background Controlled research examining maintenance treatments for responders to acute interventions for binge-eating disorder (BED) is limited. This study tested efficacy of lisdexamfetamine (LDX) maintenance treatment amongst acute resp…
View article: Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study
Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study Open
Objective The objective of this study was to test the feasibility and acceptability of a treatment for weight bullying. Method Participants who had experienced weight‐related bullying and were currently experiencing traumatic stress were r…
View article: Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder
Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder Open
Objective Adults with binge‐eating disorder (BED), compared with those without BED, demonstrate higher blood‐oxygen–level‐dependent (BOLD) response to food cues in reward‐related regions of the brain. It is not known whether cognitive beha…
View article: Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder
Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder Open
Objective To test whether overvaluation of shape/weight at the end of treatment prospectively predicts relapse at 12‐month follow‐up in patients with binge‐eating disorder (BED). Method Participants were 129 patients with BED who achieved …
View article: Reliability of the original and brief versions of the <i>Eating Disorder Examination</i> in binge‐eating disorder
Reliability of the original and brief versions of the <i>Eating Disorder Examination</i> in binge‐eating disorder Open
Objective Psychometric studies evaluating the reliability of eating‐disorder assessment among individuals with binge‐eating disorder (BED) have been limited. The current study documents the interrater reliability and internal consistency o…
View article: The children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating
The children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating Open
Objective Parental eating disorders are associated with disordered eating behaviors and psychopathology in their children, but it is not known whether parent treatment for binge‐eating disorder (BED) is associated with changes in child dis…
View article: Treatment of Eating Disorders: Current Status, Challenges, and Future Directions
Treatment of Eating Disorders: Current Status, Challenges, and Future Directions Open
Specific psychological treatments have demonstrated efficacy and represent the first-line approaches recommended for anorexia nervosa, bulimia nervosa, and binge-eating disorder. Unfortunately, many patients, particularly those with anorex…
View article: Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial
Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial Open
Background Metabolic and bariatric surgery (MBS) is the most effective and durable obesity treatment. However, there is heterogeneity in weight outcomes, which is partially attributed to variability in appetite and eating regulation. Patie…
View article: Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial Open
Objective Binge‐eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence‐based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion fo…
View article: Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity Open
Background Modest weight losses may be associated with improvements in cardiovascular disease risk factors (CVDRF) in patients with obesity. The effects of weight losses on CVDRF in persons with binge‐eating disorder (BED) are unknown. Thi…
View article: Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial (Preprint)
Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial (Preprint) Open
BACKGROUND Metabolic and bariatric surgery (MBS) is the most effective and durable obesity treatment. However, there is heterogeneity in weight outcomes, which is partially attributed to variability in appetite and eating regulation. Pati…
View article: Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial Open
Background Certain treatments have demonstrated acute efficacy for binge-eating disorder (BED) but there is a dearth of controlled research examining pharmacotherapies as maintenance treatments for responders to initial interventions. This…
View article: Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating Open
Summary This study examined baseline patient characteristics as predictors of early weight loss, defined as any weight loss within the first month of treatment, among patients receiving adjunctive behavioural treatments for loss‐of‐control…
View article: Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial Open
Objective Certain treatments have demonstrated acute efficacy for binge‐eating disorder (BED) but many patients who receive “evidence‐based” interventions do not derive sufficient benefit. Given the dearth of controlled research examining …
View article: Loss of control in binge‐eating disorder: Fear and resignation
Loss of control in binge‐eating disorder: Fear and resignation Open
Objective Binge‐eating disorder involves overeating while feeling a loss of control (LOC). Emotions around LOC appear to vary; some patients fear LOC whereas others feel powerless or “resigned” to LOC. This study examined differences in ps…
View article: Predictors and significance of rapid response to <scp>behaviorally based</scp> treatment of <scp>binge eating</scp> disorder
Predictors and significance of rapid response to <span>behaviorally based</span> treatment of <span>binge eating</span> disorder Open
Objective This study examined baseline predictors of rapid response and its prognostic significance in a clinical trial of behaviorally based weight loss treatment (BBWLT) for binge eating disorder in patients with obesity. Methods One hun…
View article: Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy Open
Objective A sizeable minority of patients with binge‐eating disorder (BED) do not fully respond to evidence‐based treatments. Evidence to guide refinements of treatments is needed. Conceptualizing BED as arising from a network of symptom‐t…
View article: Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial Open
BWL and naltrexone-bupropion were associated with significant improvements in binge-eating disorder, with a consistent pattern of BWL being superior to no BWL.
View article: A matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior
A matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior Open
Background Emerging research suggests that food intake timing, eating behavior and food preference are associated with aspects of the circadian system function but the role that the circadian system may play in binge eating (BE) behavior i…
View article: <scp>24‐Month</scp>f<scp>ollow‐up</scp>of randomized controlled trial of g<scp>uided‐self‐help</scp>for l<scp>oss‐of‐control</scp>eating after bariatric surgery
<span>24‐Month</span>f<span>ollow‐up</span>of randomized controlled trial of g<span>uided‐self‐help</span>for l<span>oss‐of‐control</span>eating after bariatric surgery Open
Background Loss‐of‐control (LOC)‐eating postoperatively predicts suboptimal longer‐term outcomes following bariatric surgery. This study examined longer‐term effects through 24‐month follow‐ups after completing treatments in a randomized c…