Carlos M. Isada
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View article: Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023
Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020–2023 Open
We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from…
View article: Rathke’s cleft cyst presenting with recurrent aseptic meningitis and inflammatory apoplexy: illustrative case
Rathke’s cleft cyst presenting with recurrent aseptic meningitis and inflammatory apoplexy: illustrative case Open
BACKGROUND Rathke’s cleft cyst (RCC) is a benign sellar/suprasellar lesion often discovered incidentally. Rarely, symptomatic cases can present with headache and may exhibit concomitant aseptic meningitis or apoplexy. The authors describe …
View article: Table of Contents
Table of Contents Open
View article: Into the unknown: Diagnosing mysterious brain lesions
Into the unknown: Diagnosing mysterious brain lesions Open
In this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts. The case presented involved a pancreas‐kidney transplant recipient wit…
View article: Teaching NeuroImages: CNS pituitary-hypothalamic Langerhans cell histiocytosis in an adult
Teaching NeuroImages: CNS pituitary-hypothalamic Langerhans cell histiocytosis in an adult Open
A 66-year-old man presented with a 6-month history of worsening confusion and panhypopituitarism. MRI showed a 1.7-cm enhancing mass involving the infundibulum and hypothalamus.1 Total body PET scan showed isolated uptake in the hypothalam…
View article: A Retrospective Multisite Case-Control Series of Concomitant Use of Daptomycin and Statins and the Effect on Creatine Phosphokinase
A Retrospective Multisite Case-Control Series of Concomitant Use of Daptomycin and Statins and the Effect on Creatine Phosphokinase Open
Objective Daptomycin has been associated with increased creatine phosphokinase (CPK) due to muscle injury leading to myalgias and muscle weakness. Statins have been proven to cause the same effects and it is recommended to discontinue the …
View article: 2546. The Mentor Model: Improving Fellow-Level Transitions of Patient Care
2546. The Mentor Model: Improving Fellow-Level Transitions of Patient Care Open
Background Our infectious disease fellows rarely see follow-up patients. Yet longitudinal patient care teaches the fellow how to approach chronic illnesses, continued clinical decline, and adverse effects of antimicrobial therapy. Fellows …
View article: Problem Based Learning (PBL) in an Infectious Diseases Fellowship
Problem Based Learning (PBL) in an Infectious Diseases Fellowship Open
Problem Based Learning (PBL) is an active learning process that adheres to key principles of adult learning theory. PBL is widely used in undergraduate medical education. To our knowledge there have been no published reports of PBL based c…
View article: Clinical Correlation of a Clostridium difficile Testing Algorithm Reflexing PCR Positive Specimens to Toxin Enzyme Immunoassay (EIA)
Clinical Correlation of a Clostridium difficile Testing Algorithm Reflexing PCR Positive Specimens to Toxin Enzyme Immunoassay (EIA) Open
Background An algorithm promoted in the United Kingdom reflexes specimens positive for C. difficile by a nucleic acid amplification test (NAAT) to toxin EIA. Samples positive by NAAT and negative by toxin EIA are reported as “C. difficile …
View article: Public Speaking Anxiety in Graduate Medical Education—A Matter of Interpersonal and Communication Skills?
Public Speaking Anxiety in Graduate Medical Education—A Matter of Interpersonal and Communication Skills? Open
Interpersonal and communication skills are part of the Accreditation Council for Graduate Medical Education competencies. Previous studies have demonstrated these skills to correlate with improved health outcomes.1Public speaking anxiety (…
View article: A Multisite Review of Concomitant Use of Daptomycin and Statins and the Effect on CPK
A Multisite Review of Concomitant Use of Daptomycin and Statins and the Effect on CPK Open
View article: Progressive multifocal leukoencephalopathy in a lung transplant recipient: Isolation of John Cunningham (JC) virus from bronchoalveolar lavage
Progressive multifocal leukoencephalopathy in a lung transplant recipient: Isolation of John Cunningham (JC) virus from bronchoalveolar lavage Open
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by polyomavirus John Cunningham (JC) virus. We report the case of a 60-year-old woman who presented 16 months after right sing…
View article: Post-Operative Infection After Surgery of Brain Tumors: A Five-Year Review of Common Pathogens, Presentation and Other Associated Factors
Post-Operative Infection After Surgery of Brain Tumors: A Five-Year Review of Common Pathogens, Presentation and Other Associated Factors Open
Methods • Patients who had an infection after brain tumor surgery at our institution from 2010-2014 were retrospectively reviewed after IRB approval • Patients with primary surgery outside the Cleveland clinic or shunt surgery after index …