Carlos A. Molina
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View article: Temporal evolution of non-contrast CT markers of expansion relates to the dynamics of acute intracerebral hemorrhage
Temporal evolution of non-contrast CT markers of expansion relates to the dynamics of acute intracerebral hemorrhage Open
Purpose The temporal evolution of non-contrast CT (NCCT) markers of intracerebral hemorrhage (ICH) expansion during the dynamics of acute ICH is understudied. We aimed to evaluate the temporal evolution of these markers and its relationshi…
View article: Mercury compound-specific stable isotope fractionation in high-altitude lake ecosystems of the Bolivian Altiplano
Mercury compound-specific stable isotope fractionation in high-altitude lake ecosystems of the Bolivian Altiplano Open
A combination of mercury (Hg) speciation and compound-specific stable isotope analyses was employed to trace the origin and fate of monomethylmercury (MMHg) in the high-altitude food webs of Lakes Titicaca (TTKK) and Uru Uru (UU). Signific…
View article: Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial Open
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with mi…
View article: A Systematic Literature Review on the Burden of Disease for Patients With Moderate to Severe Acute Ischemic Stroke
A Systematic Literature Review on the Burden of Disease for Patients With Moderate to Severe Acute Ischemic Stroke Open
Background: A vast amount of literature is available on the burden of acute ischemic stroke (AIS). Yet, most information on AIS burden does not stratify by stroke severity, and the inclusion of mild strokes (National Institute of Health St…
View article: Rescue stenting after failed mechanical thrombectomy: The RES-CAT study
Rescue stenting after failed mechanical thrombectomy: The RES-CAT study Open
Introduction The efficacy of intracranial rescue stenting (RS) following failed mechanical thrombectomy (MT) in large-vessel occlusion (LVO) stroke remains uncertain. We aimed to evaluate clinical outcomes of RS in patients with anterior c…
View article: Randomized Study Comparing First-Line Dual Versus Single-Stent Retriever Technique: TWIN2WIN
Randomized Study Comparing First-Line Dual Versus Single-Stent Retriever Technique: TWIN2WIN Open
BACKGROUND: The double-stent retriever (SR) technique has been described as an effective rescue technique when single-SR fails to induce recanalization. We aimed to assess the safety and efficacy of first-line double-SR in patients with st…
View article: Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke
Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke Open
BACKGROUND: Ischemic stroke (IS) represents a significant health burden globally, necessitating a better understanding of its genetic underpinnings to improve prevention and treatment strategies. Despite advances in IS genetics, studies fo…
View article: A Randomised Study Comparing First-line Dual Vs Single-Stentretriever Technique: TWIN2WIN
A Randomised Study Comparing First-line Dual Vs Single-Stentretriever Technique: TWIN2WIN Open
Importance Double stentretriever (double-SR) is used as a rescue technique when recanalization is not achieved in stroke patients undergoing thrombectomy. Double-SR, if applied as first-line technique could increase first-pass recanalizati…
View article: Assessment of smoking care by stroke specialists in patients with recent TIA and minor stroke: an international prospective registry-based cohort study
Assessment of smoking care by stroke specialists in patients with recent TIA and minor stroke: an international prospective registry-based cohort study Open
Objectives The objectives are to assess smoking abstinence and its effects on vascular risk and to report tobacco-cessation counselling and pharmacotherapy use in patients who had a recent minor stroke or transient ischaemic attack (TIA). …
View article: A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial
A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial Open
Background: Almost half of acute ischemic stroke patients present with mild symptoms and there are large practice variations in their treatment globally. Individuals with an intracranial occlusion who present with minor stroke are at an in…
View article: WCN24-647 MONITORING DIABETIC KIDNEY DISEASE USING THE NORA MOBILE APP. PILOT STUDY RESULTS
WCN24-647 MONITORING DIABETIC KIDNEY DISEASE USING THE NORA MOBILE APP. PILOT STUDY RESULTS Open
Diabetic kidney disease (DKD) is the most common cause of end-stage chronic kidney disease (CKD), conditioning these patients to a worse renal prognosis and higher cardiovascular mortality and/or requirement for renal replacement therapy. …
View article: Clinico-radiological features of intracranial atherosclerosis-related large vessel occlusion prior to endovascular treatment
Clinico-radiological features of intracranial atherosclerosis-related large vessel occlusion prior to endovascular treatment Open
The identification of large vessel occlusion with underlying intracranial atherosclerotic disease (ICAS-LVO) before endovascular treatment (EVT) continues to be a challenge. We aimed to analyze baseline clinical-radiological features assoc…
View article: Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events
Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events Open
Importance The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor ischemic stroke as well as their associated 5-year risks are not well known. Objective To apply the ASCOD (atherosclerosis, small ves…
View article: Editorial: Development of stroke systems of care across the globe
Editorial: Development of stroke systems of care across the globe Open
EDITORIAL article Front. Neurol., 26 September 2023Sec. Stroke Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1292036
View article: Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis
Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis Open
Introduction: Despite preventive measures, stroke rates remain high in the primary and secondary prevention settings. Factor XIa inhibition may offer a novel, safe and effective antithrombotic option for stroke prevention. Methods: We cond…
View article: O06/60 Diagnosis of intracranial atherosclerosis related large vessel occlusion before endovascular treatment
O06/60 Diagnosis of intracranial atherosclerosis related large vessel occlusion before endovascular treatment Open
Introduction The diagnosis of large vessel occlusion (LVO) with underlying intracranial atherosclerotic disease (ICAD) before endovascular treatment (EVT) continues to be a challenge. Aim We aimed to analyze baseline clinical-radiological …
View article: P039/328 Endovascular treatment in cerebral venous thrombosis: safety and efficacy in an international two-center registry
P039/328 Endovascular treatment in cerebral venous thrombosis: safety and efficacy in an international two-center registry Open
Introduction The standard acute treatment of Cerebral Venous Thrombosis (CVT) is anticoagulation. After several uncontrolled studies and one randomized clinical trial, there is still uncertainty regarding the role of endovascular treatment…
View article: Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial
Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial Open
Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: P…
View article: Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment
Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment Open
Importance ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. Objective To assess the safety and efficacy of ApTOLL in combination with endovascular treatment (EVT) for pati…
View article: Thrombolysis in Patients With Large‐Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population‐Based Study
Thrombolysis in Patients With Large‐Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population‐Based Study Open
Background Our goal is to evaluate whether the administration of thrombolytic treatment has varying effects on clinical and radiological outcomes in patients with large‐vessel occlusion stroke, based on the type of stroke center where the …
View article: Balloon‐Expandable Stenting as a Bridging Therapy in Patients With Acute Stroke and Tandem Occlusions
Balloon‐Expandable Stenting as a Bridging Therapy in Patients With Acute Stroke and Tandem Occlusions Open
Background Stenting extracranial internal carotid artery (ICA) lesions in acute ischemic stroke with tandem lesions is technically challenging. Its safety is highly debated because of the requirement of dual‐antiplatelet therapy. The optim…
View article: What is a Challenging Clot?
What is a Challenging Clot? Open
This DELPHI consensus identified 8 distinct features of a challenging clot. The varying degree of certainty amongst the panelists emphasizes the need for more pragmatic studies to enable accurate a priori identification of such occlusions …
View article: #5879 PILOT MONITORING STUDY IN PATIENTS WITH DIABETIC KIDNEY DISEASE USING NORA APPLICATION
#5879 PILOT MONITORING STUDY IN PATIENTS WITH DIABETIC KIDNEY DISEASE USING NORA APPLICATION Open
Background and Aims Diabetic Kidney Disease (DKD) is the most common cause of end-stage chronic kidney disease (CKD), conditioning these patients to a worse renal prognosis and higher cardiovascular mortality and/or requirement for renal r…
View article: Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes
Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes Open
We aim to identify a profile of intracranial thrombus resistant to recanalization by mechanical thrombectomy (MT) in acute stroke treatment. The first extracted clot of each MT was analyzed by flow cytometry obtaining the composition of th…
View article: Accuracy of a Smartwatch to Assess Heart Rate Monitoring and Atrial Fibrillation in Stroke Patients
Accuracy of a Smartwatch to Assess Heart Rate Monitoring and Atrial Fibrillation in Stroke Patients Open
(1) Background: Consumer smartwatches may be a helpful tool to screen for atrial fibrillation (AF). However, validation studies on older stroke patients remain scarce. The aim of this pilot study from RCT NCT05565781 was to validate the re…
View article: Management of acute stroke. Specific nursing care and treatments in the stroke unit
Management of acute stroke. Specific nursing care and treatments in the stroke unit Open
These guidelines provide general, evidence-based recommendations to guide professionals who care for patients with acute stroke. However, limited data are available on some aspects, showing the need for continued research on acute stroke m…
View article: Cost-utility of direct transfer to angiography suite (DTAS) bypassing conventional imaging for patients with acute ischemic stroke in Spain: results from the ANGIOCAT trial
Cost-utility of direct transfer to angiography suite (DTAS) bypassing conventional imaging for patients with acute ischemic stroke in Spain: results from the ANGIOCAT trial Open
Background The ANGIOCAT trial showed a clinical benefit of direct to angiography suite (DTAS) for patients with large vessel occlusion (LVO) stroke admitted within 6 hours after symptom onset in decreased hospital workflow time and improve…
View article: PRERISK: A Personalized, daily and AI-based stroke recurrence predictor for patient awareness and treatment compliance
PRERISK: A Personalized, daily and AI-based stroke recurrence predictor for patient awareness and treatment compliance Open
BACKGROUND The risk prediction of stroke recurrence for individual patients is a difficult task. Individualised prediction may enhance stroke survivors selfcare engagement. We have developed PRERISK: a statistical and Machine Learning (ML)…