Carlos Rossa
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View article: Biological Advantages of Calcium Hypochlorite Solution Over Sodium Hypochlorite for Regenerative Endodontic Procedures: An Ex Vivo and In Vitro Study on Human Apical Papilla
Biological Advantages of Calcium Hypochlorite Solution Over Sodium Hypochlorite for Regenerative Endodontic Procedures: An Ex Vivo and In Vitro Study on Human Apical Papilla Open
Aim Calcium hypochlorite [Ca(OCl) 2 ] has been proposed as an alternative to sodium hypochlorite (NaOCl) for use as an irrigant. This study aimed to assess morphological changes in human apical papilla (AP) ex vivo, and to evaluate viabili…
View article: Endocannabinoid system in periodontitis: A systematic review and in silico analyses
Endocannabinoid system in periodontitis: A systematic review and in silico analyses Open
The ECS participates in periodontal inflammation, with CB2 activation emerging as a promising therapeutic target.
View article: Validation in a Brazilian population of gene markers of periodontitis previously investigated by GWAS and bioinformatic studies
Validation in a Brazilian population of gene markers of periodontitis previously investigated by GWAS and bioinformatic studies Open
Background: Bioinformatic tools and genome-wide association studies (GWAS) have led to comprehensive identification of single nucleotide polymorphisms (SNPs) associated with periodontitis in diverse populations. Here we aimed to detect and…
View article: Chalcone T4 Inhibits RANKL-Induced Osteoclastogenesis and Stimulates Osteogenesis In Vitro
Chalcone T4 Inhibits RANKL-Induced Osteoclastogenesis and Stimulates Osteogenesis In Vitro Open
Chalcones are phenolic compounds produced during the biosynthesis of flavonoids that have numerous biological activities, including anti-inflammatory, antioxidant and anticancer. In this in vitro study, we investigate a newly synthesized c…
View article: Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma Open
Objective Although there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little h…
View article: Cytotoxicity and bioactive potential of new root repair materials for use with BMP-2 transfected human osteoblast cells
Cytotoxicity and bioactive potential of new root repair materials for use with BMP-2 transfected human osteoblast cells Open
Modified formulations of calcium silicate repair materials with additives have been developed to enhance handling, consistency, biocompatibility and bioactivity. Considering the relevance of osteoblastic cell response to mineralized tissue…
View article: Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects’ Periodontal, Glycemic, and Lipid Profiles
Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects’ Periodontal, Glycemic, and Lipid Profiles Open
Background. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these …
View article: Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro
Chalcone T4, a novel chalconic compound, inhibits inflammatory bone resorption in vivo and suppresses osteoclastogenesis in vitro Open
Objective This study aimed to assess the effect of a novel synthetic chalcone, Chalcone T4, on a murine model of periodontitis and on RANKL‐induced osteoclastogenesis in vitro. Background Chalcones are natural compounds with anti‐inflammat…
View article: Validation in a Brazilian population of gene markers of periodontitis previously investigated by GWAS and bioinformatic studies
Validation in a Brazilian population of gene markers of periodontitis previously investigated by GWAS and bioinformatic studies Open
Background Bioinformatic tools and genome‐wide association studies (GWAS) have led to comprehensive identification of single nucleotide polymorphisms (SNPs) associated with periodontitis in diverse populations. Here we aimed to detect and …
View article: Smoking reduces cathelicidin LL‐37 and human neutrophil peptide 1–3 levels in the gingival crevicular fluid of patients with periodontitis
Smoking reduces cathelicidin LL‐37 and human neutrophil peptide 1–3 levels in the gingival crevicular fluid of patients with periodontitis Open
Background Antimicrobial peptides are components of innate immune response that have a key role on susceptibility and resistance of the oral cavity to diseases. This study aimed to investigate the influence of smoking on cathelicidin LL‐37…
View article: Sugarcane cystatin CaneCPI‐1 promotes osteogenic differentiation in human dental pulp cells: a new insight into cysteine proteases inhibitors
Sugarcane cystatin CaneCPI‐1 promotes osteogenic differentiation in human dental pulp cells: a new insight into cysteine proteases inhibitors Open
Aim To investigate the biocompatibility, type of cell death, osteogenic bioactivity and mRNA expression of the osteogenic markers, induced by CaneCPI‐1 in human dental pulp cells (hDPCs). Methodology hDPCs exposed to CaneCPI‐1 and not expo…
View article: RAP1-RAC1 Signaling Has an Important Role in Adhesion and Migration in HNSCC
RAP1-RAC1 Signaling Has an Important Role in Adhesion and Migration in HNSCC Open
Cell-cell adhesion is a key mechanism to control tissue integrity and migration. In head and neck squamous cell carcinoma (HNSCC), cell migration facilitates distant metastases and is correlated with poor prognosis. RAP1, a ras-like protei…
View article: Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis Open
This study investigates the role of NLRP3 inflammasome and its main effector Caspase-1 in inflammation and alveolar bone resorption associated with periodontitis. Heat-killed Aggregatibacter actinomycetemcomitans (Aa) was injected 3x/week …
View article: Activin A triggers angiogenesis via regulation of VEGFA and its overexpression is associated with poor prognosis of oral squamous cell carcinoma
Activin A triggers angiogenesis via regulation of VEGFA and its overexpression is associated with poor prognosis of oral squamous cell carcinoma Open
Poor prognosis associated with the dysregulated expression of activin A in a number of malignancies has been related to with numerous aspects of tumorigenesis, including angiogenesis. The present study investigated the prognostic significa…
View article: Evaluation of recurrence of periodontal disease after treatment in obese and normal weight patients: Two‐year follow‐up
Evaluation of recurrence of periodontal disease after treatment in obese and normal weight patients: Two‐year follow‐up Open
Background Obesity may represent a chronic low‐grade inflammation, but there is a lack of long‐term longitudinal studies. The aim of this longitudinal study was to evaluate the recurrence of periodontal disease in obese and normal weight p…
View article: Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages
Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages Open
Natural products have emerged as a rich source of bioactive compounds for adjunctive treatments of many infectious and inflammatory conditions, including periodontitis. Among the monoterpenes with significant biological properties, there i…
View article: Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages
Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages Open
Natural products have emerged as a rich source of bioactive compounds for adjunctive treatments of many infectious and inflammatory conditions, including periodontitis. Among the monoterpenes with significant biological properties, there i…
View article: Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions
Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions Open
The association between rheumatoid arthritis (RA) and periodontal disease (PD) has been the focus of numerous investigations driven by their common pathological features. RA is an autoimmune disease characterized by chronic inflammation, t…