Carlos A. Aguilar‐Salinas
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View article: Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants
Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants Open
Polygenic risk scores (PRSs) can improve type 2 diabetes (T2D) risk prediction beyond clinical risk factors, but most exclude low-frequency, rare, and population-specific variants. We hypothesized that incorporation of rare variants via la…
View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: Closing the Gap: A Binational Analysis of Diabetes Mortality and Disability across the USA-Mexico Border Region
Closing the Gap: A Binational Analysis of Diabetes Mortality and Disability across the USA-Mexico Border Region Open
Aims This study characterizes the diabetes burden across USA–Mexico border states (1990–2021) by examining current patterns, temporal trends, binational comparisons, and demographic variations. Methods Using Global Burden of Disease 2021 e…
View article: Cross-Lagged Relationship Between Adiposity and HOMA and Mediating Role of Adiposity Between Lifestyle Factors and HOMA Among in Mexican Health Workers
Cross-Lagged Relationship Between Adiposity and HOMA and Mediating Role of Adiposity Between Lifestyle Factors and HOMA Among in Mexican Health Workers Open
Background/Objectives: Unhealthy lifestyles are closely linked to insulin resistance (IR) and adiposity. However, the mediating role of adiposity in the relationship between lifestyle factors and IR is not yet fully understood. Mediation a…
View article: Obesity in primary Sjögren's disease
Obesity in primary Sjögren's disease Open
According to BMI, at least 20% of patients were obese, this prevalence increased to 40% when BIA was used, with a higher prevalence found in central obesity. Obesity did not impact the symptoms and disease activity but might be associated …
View article: Lipoprotein (a) levels and clinical decision-making: data from a Mexican cohort at a tertiary medical institution
Lipoprotein (a) levels and clinical decision-making: data from a Mexican cohort at a tertiary medical institution Open
View article: Correction: Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes
Correction: Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes Open
View article: Deciphering polycystic ovary syndrome: A brief overview from metabolic drivers to genetic and fetal origins
Deciphering polycystic ovary syndrome: A brief overview from metabolic drivers to genetic and fetal origins Open
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine and metabolic disorder in women of reproductive age characterized by hormonal imbalances, menstrual irregularities, and changes in ovarian morphology. Excess body fat plays a s…
View article: 1146 Obesity/OSA Phenotypes Relative to Hypertension and Diabetes: A Cross-Sectional Study in a Mexican Population
1146 Obesity/OSA Phenotypes Relative to Hypertension and Diabetes: A Cross-Sectional Study in a Mexican Population Open
Introduction A strong association between obstructive sleep apnea (OSA) and obesity has been well documented, however, not all obese OSA patients show similar comorbidities. Two of the most common comorbidities shown by such patients are h…
View article: Publisher Correction: Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue
Publisher Correction: Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue Open
View article: Remission of Statin-associated Autoimmune Necrotizing Myopathy With Sequential Immunotherapy: A Well-studied Patient
Remission of Statin-associated Autoimmune Necrotizing Myopathy With Sequential Immunotherapy: A Well-studied Patient Open
Statins are a group of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors aimed at reducing cholesterol synthesis. Since their discovery in 1970, their use has exponentially increased, becoming a regular preventive treatment for ca…
View article: Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue
Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissue Open
View article: Genetic analysis of APOE reveals distinct origins and distribution of ancestry-enrichment haplotypes in the Mexican Biobank
Genetic analysis of APOE reveals distinct origins and distribution of ancestry-enrichment haplotypes in the Mexican Biobank Open
View article: Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes
Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes Open
This study demonstrated a positive association between VAT and LV-GLS. This relationship was consistently observed using the clinical surrogate METS-VF. Visceral adiposity was identified as a strong mediator in the relationship between IR …
View article: P310: Polygenic and rare variant contributions to the genetic architecture of familial hypercholesterolemia in a Mexican registry cohort
P310: Polygenic and rare variant contributions to the genetic architecture of familial hypercholesterolemia in a Mexican registry cohort Open
View article: Global, Regional, and National Cascades of Diabetes Care, 2000–2020: Diagnosis, Treatment, and Glycaemic Management
Global, Regional, and National Cascades of Diabetes Care, 2000–2020: Diagnosis, Treatment, and Glycaemic Management Open
View article: Factores de riesgo asociados a la referencia oftálmica urgente de pacientes diabéticos
Factores de riesgo asociados a la referencia oftálmica urgente de pacientes diabéticos Open
Antecedentes: La retinopatía diabética (RD) es la principal causa de ceguera. Es importante identificar los factores de mayor riesgo de pérdida visual. Objetivo: Identificar los factores de riesgo de referencia urgente en pacientes con dia…
View article: Dyslipidemia: recommendations for diagnosis and treatment at the first level of medical contact
Dyslipidemia: recommendations for diagnosis and treatment at the first level of medical contact Open
Cardiovascular disease is the main cause of mortality in Mexico as well as the rest of the world, with dyslipidemia being one of the main risk factors. Despite the importance of its epidemiological impact, there is still -among primary car…
View article: Biobanking for health in Latin America: a call to action
Biobanking for health in Latin America: a call to action Open
View article: Dislipidemia: recomendaciones para el diagnóstico y tratamiento en el primer nivel de contacto médico
Dislipidemia: recomendaciones para el diagnóstico y tratamiento en el primer nivel de contacto médico Open
La enfermedad cardiovascular es la principal causa de mortalidad en México y en el mundo; la dislipidemia constituye uno de los principales factores de riesgo. Pese a la importancia de su impacto epidemiológico, entre los médicos de primer…
View article: Use of meal mixed tolerance tests for assessing postprandial lipemia: a narrative review
Use of meal mixed tolerance tests for assessing postprandial lipemia: a narrative review Open
View article: Lipoprotein(a) throughout life in women
Lipoprotein(a) throughout life in women Open
Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only wit…
View article: Documento de postura de la Sociedad Mexicana de Nutrición y Endocrinología: diagnóstico y tratamiento de las dislipidemias
Documento de postura de la Sociedad Mexicana de Nutrición y Endocrinología: diagnóstico y tratamiento de las dislipidemias Open
View article: Cascadas de tamizaje y atención de la diabetes tipo 2 en México
Cascadas de tamizaje y atención de la diabetes tipo 2 en México Open
Objetivo. Actualizar las prevalencias de diabetes tipo 2 (DT2), estimar las cascadas de tamizaje y atención de la DT2 en población adulta mexicana. Material y métodos. Se utilizó la Encuesta Nacional de Salud y Nutrición 2023. Se estimó la…
View article: Obesidad en adultos
Obesidad en adultos Open
Objetivo. Describir la prevalencia de obesidad en adultos de la Encuesta Nacional de Salud y Nutrición Continua 2020-2023 (Ensanut Continua 2020-2023), sus principales características sociodemográficas, su asociación con enfermedades cróni…
View article: Detección oportuna de prediabetes y diabetes
Detección oportuna de prediabetes y diabetes Open
Objetivo. Diseñar y valorar un puntaje de riesgo para prediabetes y diabetes en adultos de 20 años no diagnosticados en México en el periodo 2021-2023. El puntaje se desarrollará con información de la Encuesta Nacional de Salud y Nutrición…
View article: A case study on the implementation of quality and comprehensive indicators set in routine diabetes care
A case study on the implementation of quality and comprehensive indicators set in routine diabetes care Open
View article: Core outcome sets for trials of interventions to prevent and to treat multimorbidity in adults in low and middle-income countries: the COSMOS study
Core outcome sets for trials of interventions to prevent and to treat multimorbidity in adults in low and middle-income countries: the COSMOS study Open
Introduction The burden of multimorbidity is recognised increasingly in low- and middle-income countries (LMICs), creating a strong emphasis on the need for effective evidence-based interventions. Core outcome sets (COS) appropriate for th…
View article: Interaction Between Primary Hyperlipidemias and Type 2 Diabetes: Therapeutic Implications
Interaction Between Primary Hyperlipidemias and Type 2 Diabetes: Therapeutic Implications Open
There is a gap of knowledge about the clinical and pathophysiological implications resulting from the interaction between primary hyperlipidemias and type 2 diabetes (T2D). Most of the existing evidence comes from sub-analyses of cohorts; …
View article: Pirfenidone Use Facts in Fibrotic Diseases: What Do We Know So Far?
Pirfenidone Use Facts in Fibrotic Diseases: What Do We Know So Far? Open
Pirfenidone has evinced noteworthy anti-inflammatory and antifibrotic efficacy in both animal models and in some clinical trials.Its pronounced potential for antifibrotic activity makes pirfenidone a compelling prospect for the treatment o…