Carlos Senne
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View article: Metagenomic detection of central nervous system infections missedby conventional testing
Metagenomic detection of central nervous system infections missedby conventional testing Open
Community-acquired infectious meningoencephalitis is associated with high rates of mortality and morbidity, compounded by limited access to diagnostic resources. The current study assessed acute central nervous system (CNS) infections in p…
View article: Phylogenetic Analysis of Varicella–Zoster Virus in Cerebrospinal Fluid from Individuals with Acute Central Nervous System Infection: An Exploratory Study
Phylogenetic Analysis of Varicella–Zoster Virus in Cerebrospinal Fluid from Individuals with Acute Central Nervous System Infection: An Exploratory Study Open
Background: There is scarce information on Varicella–Zoster virus genetic variability in individuals with acute central nervous system infection in Brazil. The objective of this study was the molecular characterization of Varicella–Zoster …
View article: EP-482 - VANTAGEM DO FILMARRAY® FRENTE AOS MÉTODOS CONVENCIONAIS NO DIAGNÓSTICO DE INFECÇÕES BACTERIANAS AGUDAS DO SISTEMA NERVOSO CENTRAL
EP-482 - VANTAGEM DO FILMARRAY® FRENTE AOS MÉTODOS CONVENCIONAIS NO DIAGNÓSTICO DE INFECÇÕES BACTERIANAS AGUDAS DO SISTEMA NERVOSO CENTRAL Open
Introdução: O diagnóstico etiológico das meningites bacterianas é fundamental para dar suporte a decisões terapêuticas acertadas, sendo crucial o início precoce dos antimicrobianos. Objetivo: Neste estudo, avaliamos o desempenho e a utilid…
View article: EP-483 - IDENTIFICAÇÃO DO HERPES VIRUS TIPO 6 NO LÍQUIDO CEFALORRAQUIDIANO DE PACIENTES COM SUSPEITA DE INFECÇÃO DO SNC PELO FILMARRAY®
EP-483 - IDENTIFICAÇÃO DO HERPES VIRUS TIPO 6 NO LÍQUIDO CEFALORRAQUIDIANO DE PACIENTES COM SUSPEITA DE INFECÇÃO DO SNC PELO FILMARRAY® Open
Introdução: O HHV-6 causa uma doença febril benigna; no entanto, pode causar doenças do sistema nervoso central. A encefalite relacionada ao HHV-6 tem sido descrita em pacientes imunocomprometidos. Há evidências crescentes que associam o H…
View article: Comparação do índice Kappa e detecção de bandas oligoclonais em amostras de líquido cefalorraquidiano de pacientes com suspeita de esclerose múltipla
Comparação do índice Kappa e detecção de bandas oligoclonais em amostras de líquido cefalorraquidiano de pacientes com suspeita de esclerose múltipla Open
Objetivo: A avaliação da produção intratecal de IgG é útil na avaliação de casos suspeitos de esclerose múltipla. A detecção qualitativa de bandas oligoclonais (OCBs) no líquido cefalorraquidiano (LCR) e soro e o índice Kappa são atualment…
View article: Imunofenotipagem e citologia oncótica em amostras de líquido cefalorraquidiano no diagnóstico de infiltração neoplásica meníngea em pacientes com linfomas
Imunofenotipagem e citologia oncótica em amostras de líquido cefalorraquidiano no diagnóstico de infiltração neoplásica meníngea em pacientes com linfomas Open
Objetivo: O diagnóstico de infiltração neoplásica meníngea em pacientes com neoplasias hematológicas pode ser feito pela citomorfologia e pela imunofenotipagem em amostras de líquido cefalorraquidiano. Neste estudo, avaliamos os resultados…
View article: Use of immunophenotyping and cytomorphology in cerebrospinal fluid (CSF) samples for diagnosis of neurological involvement in patients with leukemia
Use of immunophenotyping and cytomorphology in cerebrospinal fluid (CSF) samples for diagnosis of neurological involvement in patients with leukemia Open
Background: Lymphoid and myeloid leukemias are hematological neoplasms with the highest risk of central nervous system infiltration. The presence of neurological involvement in these conditions has very important therapeutic consequences. …
View article: Diagnóstico laboratorial das doenças associadas ao anticorpo glicoproteína de oligodendrócitos da mielina
Diagnóstico laboratorial das doenças associadas ao anticorpo glicoproteína de oligodendrócitos da mielina Open
Objetivo: O exame Anti-MOG por CBA (Cell-Based Assay) é um teste diagnóstico usado para identificar anticorpos contra a glicoproteína oligodendrócito de mielina (MOG). O MOG é um componente da mielina no sistema nervoso central. A detecção…
View article: Meningite bacteriana por Listeria innocua em uma paciente idosa: diagnóstico e considerações clínicas
Meningite bacteriana por Listeria innocua em uma paciente idosa: diagnóstico e considerações clínicas Open
Objetivo: A meningite bacteriana por Listeria é pouco frequente, mas potencialmente grave. A identificação precisa do agente causal é crucial para o tratamento antimicrobiano adequado e para o melhor desfecho clínico. Avanços em técnicas d…
View article: Imunofenotipagem e citologia oncótica em líquido cefalorraquidiano no diagnóstico de infiltração neoplásica meníngea em casos de neoplasias hematológicas
Imunofenotipagem e citologia oncótica em líquido cefalorraquidiano no diagnóstico de infiltração neoplásica meníngea em casos de neoplasias hematológicas Open
Objetivo: O diagnóstico de infiltração neoplásica meníngea em pacientes com neoplasias hematológicas pode ser feito pela citomorfologia e pela imunofenotipagem. Neste estudo, avaliamos os resultados obtidos com os dois métodos em pacientes…
View article: Clinical utility of FilmArray® in the diagnosis of nervous system infections
Clinical utility of FilmArray® in the diagnosis of nervous system infections Open
Introduction: The FilmArray® meningitis/encephalitis is a multiplex polymerase chain reaction for identifying 14 agents of central nervous system (CNS) infections, including bacteria, Cryptococcus and viruses. In this study, we retrospecti…
View article: Use of FilmArray® in the diagnosis of bacterial meningitis
Use of FilmArray® in the diagnosis of bacterial meningitis Open
Introduction: The Meningitis/Encephalitis FilmArray is an automated multiplex polymerase chain reaction for identifying 14 central nervous system (CNS) care agents, including viruses, Cryptococcus, and bacteria. The following bacteria are …
View article: Clear and colorless cerebrospinal fluid among suspected central nervous system infections
Clear and colorless cerebrospinal fluid among suspected central nervous system infections Open
Introduction: The physical examination of the cerebrospinal fluid (CSF) is part of its routine evaluation and is easily performed as soon as CSF is obtained. However, its predictive value of CSF abnormalities is poorly known. Objective: In…
View article: Kappa index and oligoclonal bands detection in cerebrospinal fluid samples of patients with suspected multiple sclerosis
Kappa index and oligoclonal bands detection in cerebrospinal fluid samples of patients with suspected multiple sclerosis Open
Introduction: The evaluation of the intrathecal production of immunoglobulin G (IgG) can be useful in the evaluation of multiple sclerosis (MS) suspected cases and the most important test to verify it is the detection of oligoclonal bands …
View article: Diagnosis of neurosyphilis with cerebrospinal fluid pcr: a systematic review
Diagnosis of neurosyphilis with cerebrospinal fluid pcr: a systematic review Open
Background Neurosyphilis is difficult to be diagnosed. CSF VDRL is the gold standard, but its sensitivity is low. Cerebrospinal fluid (CSF) PCR for the detection of Treponema pallidum DNA has been evaluated; however, its diagnostic value i…
View article: Diagnosis of neurosyphilis with cerebrospinal fluid pcr: a systematic review
Diagnosis of neurosyphilis with cerebrospinal fluid pcr: a systematic review Open
Background Neurosyphilis is difficult to be diagnosed. CSF VDRL is the gold standard, but its sensitivity is low. Cerebrospinal fluid (CSF) PCR for the detection of Treponema pallidum DNA has been evaluated; however, its diagnostic value i…
View article: Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report
Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report Open
Background Neurofilament Light (NfL) chain levels in both cerebrospinal fluid (CSF) and serum have been correlated with the reduction of axonal damage in multiple sclerosis (MS) patients treated with Natalizumab (NTZ). However, little is k…
View article: First Case Of SAR-Coronavirus-2 Sequencing In The Cerebrospinal Fluid Of A Patient With Suspected CNS Demyelinating Disease
First Case Of SAR-Coronavirus-2 Sequencing In The Cerebrospinal Fluid Of A Patient With Suspected CNS Demyelinating Disease Open
The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating …
View article: FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis
FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis Open
View article: Neurofilament light chain in the assessment of patients with multiple sclerosis
Neurofilament light chain in the assessment of patients with multiple sclerosis Open
Multiple sclerosis (MS) is an autoimmune, inflammatory, and degenerative disease of the central nervous system. Axonal degeneration is triggered by inflammation and is the pathological substrate of progressive disability in patients with M…
View article: Assessment of cytological and biochemical parameters stability in cerebrospinal fluid
Assessment of cytological and biochemical parameters stability in cerebrospinal fluid Open
Objective: The aim of this study was to evaluate the stability, in 12 hours, of cytological and biochemical parameters of the cerebrospinal fluid (CSF). Methods: Cerebrospinal fluid (CSF) samples were aliquoted into five different tubes an…
View article: Performance of lactate in discriminating bacterial meningitis from enteroviral meningitis
Performance of lactate in discriminating bacterial meningitis from enteroviral meningitis Open
The cytological and biochemical examination of cerebrospinal fluid (CSF) has been used for the presumed diagnosis of bacterial meningitis until the final microbiological results are achieved. We assessed the ability of CSF lactate in compa…
View article: Assessment of cytological and biochemical parameters stability in cerebrospinal fluid
Assessment of cytological and biochemical parameters stability in cerebrospinal fluid Open
Objective: The aim of this study was to evaluate the stability, in 12 hours, of cytological and biochemical parameters of the cerebrospinal fluid (CSF). Methods: Cerebrospinal fluid (CSF) samples were aliquoted into five different tubes an…
View article: Lumbar puncture in patients using anticoagulants and antiplatelet agents
Lumbar puncture in patients using anticoagulants and antiplatelet agents Open
The use of anticoagulants and antiplatelet agents has largely increased. Diagnostic lumbar puncture in patients taking these drugs represents a challenge considering the opposing risks of bleeding and thrombotic complications. To date ther…
View article: Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients
Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients Open
Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and te…