Explanipedia

Hospital Variations in Time‐To‐Crisis‐Resolution Among Children and Adolescents With Sickle Cell Disease Open

Chris A. Rees, Dunia Hatabah, Rawan Korman, Fahd A. Ahmad, Gladstone Airewele , et al. · 2025

Analysis of the placebo cohort in the STArT trial shows that patient characteristics and hospital site strongly influence time-to-crisis-resolution and total opioid use in children and young adults with sickle cell disease, highlighting th…

The psychometric properties of the stoplight pain scale in children with sickle cell disease Open

Daniel S. Tsze, Nitya Bakshi, Kathleen M. Brown, T. Charles Casper, Corrie E. Chumpitazi , et al. · 2025

Background: Effective pain management begins with accurate pain assessment for children with sickle cell disease (SCD) experiencing a vaso-occlusive episodes (VOE). While most scales measure pain, these traditional tools do not guide thera…

Impact of hydroxyurea on pediatric sleep in sickle cell disease Open

Min Heui Yoo, Shasha Bai, Gerhard W. Kalmus, Lindsey Abel, Carlton Dampier , et al. · 2025

Physical activity among adolescents and young adults living with chronic pain and sickle cell disease: a qualitative examination Open

Jan Mooney, Cynthia Sinha, Nitya Bakshi, Alicia Nuñez, Taylor Adkins , et al. · 2025

Objectives Chronic pain among youth with sickle cell disease (SCD) is associated with significant functional disability. Physical activity is recommended for pediatric chronic pain and is safe, feasible, and beneficial for individuals with…

Protocol for a Multisite Trial Evaluating Digital Cognitive Behavioral Therapy With and Without Peer Support Among Adolescents and Young Adults With Chronic Sickle Cell Pain Open

Stefan Siebert, Kadeem Gayle, Alicia Colvin, Ana Radović, Wally R. Smith , et al. · 2025

Background The transition from adolescence to adulthood in individuals with sickle cell disease (SCD) is a time of high risk for both acute and chronic pain, contributing to poor physical and mental health outcomes. Digital cognitive behav…

Treatment Experience Using a Micro‐Induction Buprenorphine Protocol for Chronic Pain in Pediatric Sickle Cell Disease Open

Ashwin Patel, Gerhard W. Kalmus, Carlton Dampier, Ifeyinwa Osunkwo, Tamara New , et al. · 2025

Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of inef…

0989 Impact of Sickle Cell Disease Modifying Therapies on Pediatric Sleep Open

Min Heui Yoo, Shasha Bai, Tracy Huang, Gerhard W. Kalmus, Lindsey Abel , et al. · 2025

Introduction Children with sickle cell disease (SCD) have a higher prevalence of sleep disturbances, adenotonsillar hypertrophy, and obstructive sleep apnea (OSA) than the general population. Disease-modifying therapies such as hydroxyurea…

Arginine Therapy for Pain in Sickle Cell Disease: A Phase‐2 Randomized, Placebo‐Controlled Trial Open

Claudia R. Morris, Dunia Hatabah, Rawan Korman, Scott Gillespie, Nitya Bakshi , et al. · 2025

We present a prospective randomized, placebo‐controlled trial of intravenous arginine in patients 3–21 years hospitalized with sickle cell disease vaso‐occlusive pain episodes (SCD‐VOE) at two tertiary‐care children's hospitals. Participan…

Moderators of digital cognitive-behavioral therapy for youth with sickle cell disease pain: secondary analysis of a randomized controlled trial Open

Tonya M. Palermo, Kavin Srinakarin, Chuan Zhou, Chitra Lalloo, Carlton Dampier , et al. · 2025

Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth with SCD develop chronic SCD pain. Our randomized controlled trial found significant reductions in pain in youth receiving digital cognitive-behavioral…

Cobalamin Deficiency in Children and Adolescents with Sickle Cell Disease Open

Dunia Hatabah, Rachel Krieger, Lou Ann S. Brown, Frank Harris, Rawan Korman , et al. · 2025

Background/Objective: Cobalamin (B12) deficiency is reported in 18% of adults with sickle cell disease (SCD) and only 10% without SCD; limited data are available on children. Diagnosing B12 deficiency is challenging given the lack of an es…

Management of post-operative anaemia in patients undergoing surgery for colorectal cancer: a qualitative focus group-based study Open

Samuel Lawday, Susannah Williams, Elizabeth C James, Emma L. Court, Fiona Carter , et al. · 2025

Treatment experience using a micro-induction buprenorphine protocol for chronic pain in pediatric sickle cell sickle disease. Open

Elna Saah, Gerhard W. Kalmus, Ashwin Patel, Carlton Dampier, Ifeyinwa Osunkwo , et al. · 2024

Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease. Open

Mark C. Walters, Mary Eapen, Yiwen Liu, Fuad El Rassi, Edmund K. Waller , et al. · 2024

Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Do…

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease Open

Mark C. Walters, Mary Eapen, Yiwen Liu, Fuad El Rassi, Edmund K. Waller , et al. · 2024

Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2 years after biologic assignment to a do…

6921 Almost a Thyroid Malignancy but Not Quite! A Rare Case of Follicular Neoplasm with Uncertain Malignant Potential Open

Geethika Thota, Carlton Dampier, Tae Sun Jin, Kenneth Luberice, Sachin R. Jhawar , et al. · 2024

Disclosure: G.P. Thota: None. C. Dampier: None. T. Jin: None. K. Luberice: None. S. Jhawar: None. A. Grover: None. P. Veeraraghavan: None. A. Gharib: None. S. Sadowski: None. M. Roth: None. A. Filie: None. S. Hewitt: None. M. A. Zeiger: No…

What is the future of digital tools to help manage pain in sickle cell disease patients? Open

Carlton Dampier · 2024

KEYWORDS: Sickle cell diseaseself-managementmHealthsmartphonessmartwatchesdigital health interventionssensors

Cobalamin Deficiency in Children with Sickle Cell Disease Open

Dunia Hatabah, Rachel Kreiger, Lou Ann S. Brown, Frank Harris, Rawan Korman , et al. · 2024

Presentation Date: 6/9/2024 Presentation Start Time: 1:51:00 PM Background Cobalamin (B12)-deficiency has been reported in 18% of adults with sickle cell disease (SCD) vs 10% in adults without SCD. The prevalence of B12-deficiency in child…

Pain Influences Executive Function Via Depression in Adults with Sickle Cell Disease Open

Charles R. Jonassaint, Donald L Bearden, Julia A. O’Brien, Kim E Ono, Lindsey L. Cohen , et al. · 2024

Presentation Date: 6/9/2024 Presentation Start Time: 3:00:00 PM Background Patients with sickle cell disease (SCD) are highly vulnerable to pain, cognitive problems, and depression compared to their healthy peers. A rich literature has sho…

Impact of arginine therapy on kyotorphin in children with sickle cell disease and vaso-occlusive pain Open

Rawan Korman, Dunia Hatabah, Lou Ann S. Brown, Frank Harris, Hagar Wilkinson , et al. · 2024

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Opioid Use After First Opioid Prescription in Children With Sickle Cell Disease Open

Angela Snyder, Mei Zhou, Brandon K. Attell, Lindsey L. Cohen, Sierra Carter , et al. · 2024

This cohort study assesses the level of opioid use, number of vaso-occlusive crises, and days’ supply of opioids among opioid-naive pediatric patients.

A cognitive–behavioral digital health intervention for sickle cell disease pain in adolescents: a randomized, controlled, multicenter trial Open

Tonya M. Palermo, Chitra Lalloo, Chuan Zhou, Carlton Dampier, William T. Zempsky , et al. · 2023

Severe acute and chronic pain are the most common complications of sickle cell disease (SCD). Pain results in disability, psychosocial distress, repeated clinic visits/hospitalizations, and significant healthcare costs. Psychosocial pain i…

Sickle Cell Disease Treatment with Arginine Therapy (STArT): study protocol for a phase 3 randomized controlled trial Open

Chris A. Rees, David C. Brousseau, Daniel M. Cohen, Anthony Villella, Carlton Dampier , et al. · 2023

Background Despite substantial illness burden and healthcare utilization conferred by pain from vaso-occlusive episodes (VOE) in children with sickle cell disease (SCD), disease-modifying therapies to effectively treat SCD-VOE are lacking.…

Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspective Open

Chris A. Rees, David C. Brousseau, Fahd A. Ahmad, Jonathan E. Bennett, Seema Bhatt , et al. · 2023

Children with sickle cell disease (SCD) commonly experience vaso‐occlusive pain episodes (VOE) due to sickling of erythrocytes, which often requires care in the emergency department. Our objective was to assess the use and impact of intran…

Patient-reported outcomes in children with sickle cell disease at presentation for an acute pain episode Open

Nitya Bakshi, Zihao Liu, Scott Gillespie, Rohali Keesari, Deborah Leake , et al. · 2022

Identifying Chronic Pain Subgroups in Pediatric Sickle Cell Disease Open

Soumitri Sil, Alison Manikowski, Mallory Schneider, Lindsey L. Cohen, Carlton Dampier · 2022

Objectives: Youth with sickle cell disease (SCD) and chronic pain, defined in this study as pain on most days for 3 months, experience variability in daily pain and physical and psychosocial functioning. This study aimed to (1) empirically…

Adherence to <span>NHLBI</span> guidelines for the emergent management of <span>vaso‐occlusive</span> episodes in children with sickle cell disease: A multicenter perspective Open

Chris A. Rees, David C. Brousseau, Fahd A. Ahmad, Jonathan E. Bennett, Seema Bhatt , et al. · 2022

To the Editor: Patients with sickle cell disease (SCD) commonly experience vaso-occlusive pain episodes (VOE), which accounts for 78% of all emergency department (ED) visits among patients with SCD.1 SCD-VOE pain is often under-, and incon…

Characterizing User Engagement With a Digital Intervention for Pain Self-management Among Youth With Sickle Cell Disease and Their Caregivers: Subanalysis of a Randomized Controlled Trial Open

Chitra Lalloo, Fareha Nishat, William T. Zempsky, Nitya Bakshi, Sherif M. Badawy , et al. · 2022

Background Sickle cell disease (SCD) is characterized by severe acute pain episodes as well as risk for chronic pain. Digital delivery of SCD pain self-management support may enhance pain self-management skills and accessibility for youth.…

Development and evaluation of the patient-reported outcomes measurement information system (PROMIS) pediatric pain quality item bank and short form Open

Constance A. Mara, Adam C. Carle, Kenneth R. Goldschneider, Susmita Kashikar‐Zuck, David D. Sherry , et al. · 2022

Pain is a common problem among children, particularly those with pediatric chronic diseases. Multifaceted assessment of pain can improve communication about pain and help clinicians characterize, differentiate, and treat a patient's unique…

iCanCope with Sickle Cell Disease: Characterizing user engagement with a digital intervention for pain self-management among youth and caregivers (Preprint) Open

Chitra Lalloo, Fareha Nishat, William T. Zempsky, Nitya Bakshi, Sherif M. Badawy , et al. · 2022

BACKGROUND Sickle cell disease (SCD) is characterized by severe acute pain episodes as well as risk for chronic pain. Developing pain self-management skills early in the disease trajectory can support improved pain coping. Digital deliver…

A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia Open

David C. Rees, Yurdanur Kılınç, Selma Ünal, Carlton Dampier, Betty S. Pace , et al. · 2022

Excessive intravascular release of lysed cellular contents from damaged red blood cells (RBCs) in patients with sickle cell anemia (SCA) can activate the inflammasome, a multiprotein oligomer promoting maturation and secretion of proinflam…

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