Explanipedia

Artificial intelligence fully automated analysis of handheld echocardiography in real‐world patients with suspected heart failure Open

Ross T. Campbell, Mark C Petrie, Kieran F. Docherty, Katriona Brooksbank, Gemma McKinley , et al. · 2025

Aims Echocardiography is a rate‐limiting step in the timely diagnosis of heart failure (HF). Automated reporting of echocardiograms has the potential to streamline workflow. The aim of this study was to test the diagnostic accuracy of full…

Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes Open

Kirsty McDowell, Carly Adamson, Colette E. Jackson, Ross T. Campbell, Paul Welsh , et al. · 2023

Aims Neuropeptide Y (NPY) is the most abundant neuropeptide found in the heart and is released alongside norepinephrine following prolonged sympathetic activation, a process that is implicated in the pathophysiology of heart failure (HF). …

Impact of comorbidities on health status measured using the Kansas City Cardiomyopathy Questionnaire in patients with heart failure with reduced and preserved ejection fraction Open

Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham , et al. · 2023

Aim Patients with heart failure (HF) often suffer from a range of comorbidities, which may affect their health status. The aim of this study was to assess the impact of different comorbidities on health status in patients with HF and reduc…

Knowledge about self‐efficacy and outcomes in patients with heart failure and reduced ejection fraction Open

Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham , et al. · 2023

Aim Although education in self‐management is thought to be an important aspect of the care of patients with heart failure, little is known about whether self‐rated knowledge of self‐management is associated with outcomes. The aim of this s…

Joint modelling of longitudinal processes and time-to-event outcomes in heart failure: systematic review and exemplar examining the relationship between serum digoxin levels and mortality Open

Ryan Field, Carly Adamson, Pardeep S. Jhund, Jim Lewsey · 2023

Prevalent and Incident Anemia in PARADIGM-HF and the Effect of Sacubitril/Valsartan Open

James P. Curtain, Carly Adamson, Kieran F. Docherty, Pardeep S. Jhund, Akshay S. Desai , et al. · 2023

Irrespective of anemia status, sacubitril/valsartan compared with enalapril, decreased mortality and hospitalization. Hemoglobin decreased less with sacubitril/valsartan and the incidence of new anemia was lower with sacubitril/valsartan. …

Adverse Outcomes Associated With Interleukin-6 in Patients Recently Hospitalized for Heart Failure With Preserved Ejection Fraction Open

Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh , et al. · 2023

Background: Inflammation may play a role in the pathophysiology of heart failure with preserved ejection fraction. We examined whether circulating levels of interleukin-6 identify patients at greater risk of adverse outcomes following hosp…

Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction Open

James P. Curtain, Carly Adamson, Toru Kondo, Jawad H. Butt, Akshay S. Desai , et al. · 2023

Aims Few reports have examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) or their relationship with mortality in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or heart fail…

IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction Open

Carly Adamson, Paul Welsh, Kieran F. Docherty, Rudolf A. de Boer, Mirta Díez , et al. · 2022

Higher IGFBP-7 in patients with HFrEF was associated with worse clinical profile and an increased risk of adverse clinical outcomes. IGFBP-7 provided prognostic information incremental to clinical variables, NT-proBNP, and hsTnT. The benef…

Coronary perforation incidence and temporal trends (COPIT): systematic review and meta-analysis Open

Philopatir Mikhail, N. Howden, M Monjur, C. Said, Prajith Jeyaprakash , et al. · 2022

Background Despite advancements in Percutaneous Coronary Intervention (PCI) technology and techniques, iatrogenic coronary artery perforation (CAP) remains a dreaded potential complication within the cardiac catheterisation laboratory. Dat…

Coronary perforation incidence, outcomes and temporal trends (COPIT): a systematic review and meta-analysis Open

Philopatir Mikhail, N. Howden, Mohammad Monjur, Prajith Jeyaprakash, Christian Said , et al. · 2022

Coronary perforation is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We studied incidence, outcomes and temporal trends following PCI-related coronary artery perforation (CAP). Methods Prospectiv…

Alkaline phosphatase and bilirubin combined are a powerful predictor of outcome in patients with heart failure and reduced ejection fraction: an analysis of the ATMOSPHERE and PARADIGM-HF trials Open

Carly Adamson, J H Butt, Jean-Lucien Rouleau, William T. Abraham, AS Desai , et al. · 2022

Introduction Bilirubin is a recognized predictor of adverse outcomes in patients with heart failure and reduced ejection fraction (HFrEF), possibly because it is a marker of congestion. Alkaline phosphatase (ALP) is an enzyme produced in m…

Outcomes related to IGFBP-7 in patients with heart failure and reduced ejection fraction and effects of dapagliflozin: findings from DAPA-HF Open

Carly Adamson, Paul Welsh, David A. Morrow, Kieran F. Docherty, Ann Hammarstedt , et al. · 2022

Introduction Insulin-like growth factor binding protein 7 (IGFBP-7) has been proposed as a novel prognostic biomarker in heart failure, but the association between IGFBP-7 and cardiovascular outcomes has not been examined in a large cohort…

Coronary Artery Perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study Open

Thomas J. Ford, Carly Adamson, Andrew Morrow, Paul Rocchiccioli, Damien Collison , et al. · 2022

Background The objective of the GNOCCI (Glasgow Natural History Study of Covered Stent Coronary Interventions) Study was to report the incidence and outcomes of coronary artery perforations over an 18‐year period at a single, high‐volume p…

Dapagliflozin for heart failure according to body mass index: the DELIVER trial Open

Carly Adamson, Toru Kondo, Pardeep S. Jhund, Rudolf A. de Boer, Jose Walter Cabrera Honorio , et al. · 2022

Aims Obesity is common and associated with unique phenotypic features in heart failure with preserved ejection fraction (HFpEF). Therefore, understanding the efficacy and safety of new therapies in HFpEF patients with obesity is important.…

Liver tests and outcomes in heart failure with reduced ejection fraction: findings from <span>DAPA‐HF</span> Open

Carly Adamson, Lorna M. Cowan, Rudolf A. de Boer, Mirta Díez, Jarosław Dróżdż , et al. · 2022

Aims Reflecting both increased venous pressure and reduced cardiac output, abnormal liver tests are common in patients with severe heart failure and are associated with adverse clinical outcomes. We aimed to investigate the prognostic sign…

Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF Open

Carly Adamson, Kieran F. Docherty, Hiddo J.L. Heerspink, Rudolf A. de Boer, Kevin Damman , et al. · 2022

Background: In a post hoc analysis, the frequency of occurrence of an early decline (dip) in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin and its association with outcomes were evaluated in patients with he…

Eligibility for pharmacological therapies in heart failure with reduced ejection fraction: implications of the new Chronic Kidney Disease Epidemiology Collaboration creatinine equation for estimating glomerular filtration rate Open

Jawad H. Butt, Carly Adamson, Kieran F. Docherty, Muthiah Vaduganathan, Scott D. Solomon , et al. · 2022

Aims The new Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation for estimating glomerular filtration rate (eGFR), based on serum creatinine, that does not incorporate race may reclassify individuals, irrespective of race,…

Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index Open

Carly Adamson, Pardeep S. Jhund, Kieran F. Docherty, Jan Bělohlávek, Chern‐En Chiang , et al. · 2021

Aims In heart failure with reduced ejection fraction (HFrEF), there is an ‘obesity paradox’, where survival is better in patients with a higher body mass index (BMI) and weight loss is associated with worse outcomes. We examined the effect…

Post-operative myocardial infarction following aortic root surgery with coronary reimplantation: a case series treated with percutaneous coronary intervention Open

Carly Adamson, Paul Rocchiccioli, Richard Brogan, Colin Berry, Thomas J. Ford · 2019

Background Coronary ostial stenosis is an uncommon but potentially lethal complication following aortic root replacement with or without aortic valve replacement (including Bentall and David procedures). This manifests clinically as acute …

‘Take Ten’ improving the surgical post-take ward round: a quality improvement project Open

D Banfield, Carly Adamson, Amy Tomsett, James Povey, Tony Fordham , et al. · 2018

Background The surgical post-take ward round is a complex multidisciplinary interaction in which new surgical patients are reviewed and management plans formulated. Its fast-paced nature can lead to poor communication and inaccurate or inc…

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