Carmela Fimognari
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View article: Boosting curcumin derivatives' cytotoxicity in cancer cells with light: An in vitro study
Boosting curcumin derivatives' cytotoxicity in cancer cells with light: An in vitro study Open
Curcumin is a natural compound with well-documented anticancer potential, but its clinical use is limited by poor water solubility and low bioavailability. To address these limitations, various nanoformulations and synthetic or semi-synthe…
View article: Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey
Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey Open
View article: Health-promoting and medicinal properties of Zingiberaceae family plants: A minireview with a special focus on galangal, turmeric, cardamom, and ginger
Health-promoting and medicinal properties of Zingiberaceae family plants: A minireview with a special focus on galangal, turmeric, cardamom, and ginger Open
View article: Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes
Hyaluronic Acid Hampers the Inflammatory Response Elicited by Extracellular Vesicles from Activated Monocytes in Human Chondrocytes Open
Background/Objectives: Osteoarthritis (OA) is the most common joint disease in the adult population. OA is the result of multiple mechanisms leading to inflammation and the degradation of the cartilage. A complex series of etiological acto…
View article: New rhodol-sulforaphane conjugates as innovative isothiocyanate-based cytotoxic agents for cancer cells
New rhodol-sulforaphane conjugates as innovative isothiocyanate-based cytotoxic agents for cancer cells Open
View article: Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells
Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells Open
View article: Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer Open
Rationally designed quinone-based histone deacetylase inhibitors have been characterized in vitro , showing potential against two of the most devastating diseases of the 21st century.
View article: Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes
Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes Open
Fresh bulbs of Stenomesson miniatum, a plant belonging to the Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this stud…
View article: Phytochemical Characterization and Biological Activities of Stenomesson miniatum Bulb Extract, a Medicinal Plant of the Andes.
Phytochemical Characterization and Biological Activities of Stenomesson miniatum Bulb Extract, a Medicinal Plant of the Andes. Open
The fresh bulbs of Stenomesson miniatum, a plant belonging to Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this study were …
View article: Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes
Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes Open
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View article: Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies
Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies Open
View article: Antimutagenicity and Antioxidant Activity of Castanea sativa Mill. Bark Extract
Antimutagenicity and Antioxidant Activity of Castanea sativa Mill. Bark Extract Open
Castanea sativa Mill. (Cs), a plant traditionally employed in nutrition and to treat various respiratory and gastrointestinal infections, possesses cancer chemopreventive characteristics. In particular, Cs bark extract previously demonstra…
View article: Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects Open
Angiogenesis and metastasis represent two challenging targets to combat cancer development in the later stages of its progression. Numerous studies have indicated the important role of natural products in blocking tumor angiogenesis signal…
View article: Phytochemical Characterization and Biological Activities of<em> Stenomesson miniatum </em>Bulb Extract, a Medicinal Plant of the Andes
Phytochemical Characterization and Biological Activities of<em> Stenomesson miniatum </em>Bulb Extract, a Medicinal Plant of the Andes Open
The fresh bulbs of Stenomesson miniatum, a plant belonging to Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this study were …
View article: Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery
Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery Open
In this interdisciplinary study, we selected two compounds, namely, smenamide A, a peptide–polyketide, and smenolactone D, a polyketide, as models because they are representative of two different classes of molecules isolated from the mari…
View article: Identification of Blood Transport Proteins to Carry Temoporfin: A Domino Approach from Virtual Screening to Synthesis and In Vitro PDT Testing
Identification of Blood Transport Proteins to Carry Temoporfin: A Domino Approach from Virtual Screening to Synthesis and In Vitro PDT Testing Open
Temoporfin (mTHPC) is one of the most promising photosensitizers used in photodynamic therapy (PDT). Despite its clinical use, the lipophilic character of mTHPC still hampers the full exploitation of its potential. Low solubility in water,…
View article: Light-Enhanced Cytotoxicity of Doxorubicin by Photoactivation
Light-Enhanced Cytotoxicity of Doxorubicin by Photoactivation Open
The combination of photodynamic therapy with chemotherapy (photochemotherapy, PCT) can lead to additive or synergistic antitumor effects. Usually, two different molecules, a photosensitizer (PS) and a chemotherapeutic drug are used in PCT.…
View article: Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes.
Phytochemical characterization and biological activities of <i>Stenomesson miniatum</i> bulb extract, a medicinal plant of the Andes. Open
Fresh bulbs of Stenomesson miniatum, a plant belonging to the Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this stud…
View article: Effect of the Marine Polyketide Plocabulin on Tumor Progression
Effect of the Marine Polyketide Plocabulin on Tumor Progression Open
Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer prop…
View article: Carrying Temoporfin with Human Serum Albumin: A New Perspective for Photodynamic Application in Head and Neck Cancer
Carrying Temoporfin with Human Serum Albumin: A New Perspective for Photodynamic Application in Head and Neck Cancer Open
Temoporfin (mTHPC) is approved in Europe for the photodynamic treatment of head and neck squamous cell carcinoma (HNSCC). Although it has a promising profile, its lipophilic character hampers the full exploitation of its potential due to h…
View article: The Anti- and Pro-Tumorigenic Role of Microbiota and Its Role in Anticancer Therapeutic Strategies
The Anti- and Pro-Tumorigenic Role of Microbiota and Its Role in Anticancer Therapeutic Strategies Open
Human gut microbiota physiologically and actively participates as a symbiont to a wide number of fundamental biological processes, such as absorption and metabolism of nutrients, regulation of immune response and inflammation; gut microbio…
View article: In Vitro Investigation of the Anticancer Properties of Ammodaucus Leucotrichus Coss. & Dur.
In Vitro Investigation of the Anticancer Properties of Ammodaucus Leucotrichus Coss. & Dur. Open
Little is known about the pharmacological activity of Ammodaucus leucotrichus Coss. & Dur., a small annual species that grows in the Saharan and sub-Saharan countries. In the present study, we investigated whether the standardized ethanoli…
View article: Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review
Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review Open
Cancer affects more than 19 million people and is the second leading cause of death in the world. One of the principal strategies used in cancer therapy is the inhibition of topoisomerase II, involved in the survival of cells. Side effects…
View article: Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus
Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus Open
The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced b…
View article: New regulation on medical devices made of substances: Opportunities and challenges for pharmacological and toxicological research
New regulation on medical devices made of substances: Opportunities and challenges for pharmacological and toxicological research Open
The Medical Device (MD) Regulation EU 2017/745 (MDR) has provided a completely new and more robust regulatory framework at guarantee of the safety and efficacy of therapeutic options accessing the market. At the same time, the MDR poses se…
View article: Perillaldehyde is a new ferroptosis inducer with a relevant clinical potential for acute myeloid leukemia therapy
Perillaldehyde is a new ferroptosis inducer with a relevant clinical potential for acute myeloid leukemia therapy Open
View article: On the toxicity of e-cigarettes consumption: Focus on pathological cellular mechanisms
On the toxicity of e-cigarettes consumption: Focus on pathological cellular mechanisms Open
View article: Characterization of the Biological Activity of the Ethanolic Extract from the Roots of Cannabis sativa L. Grown in Aeroponics
Characterization of the Biological Activity of the Ethanolic Extract from the Roots of Cannabis sativa L. Grown in Aeroponics Open
Cannabis sativa var. Kompolti, a variety routinely used for food production purposes, is characterized by a low concentration of psychoactive molecules, although containing many other biologically attractive metabolites in all parts of the…
View article: Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives
Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives Open
View article: Anticancer potential of allicin: A review
Anticancer potential of allicin: A review Open