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View article: In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors
In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors Open
Background Imagining ways to prevent or treat glioblastoma (GBM) has been hindered by a lack of understanding of its pathogenesis. Although overexpression of platelet derived growth factor with two A-chains (PDGF-AA) may be an early event,…
View article: Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM
Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM Open
Background Imagining ways to prevent or treat glioblastoma (GBM) have been hindered by a lack of understanding of its pathogenesis. Although PDGF-AA overexpression may be an early event, critical details of the core biology are lacking. Ex…
View article: TMOD-02. A MODEL OF THE INITIATION AND GENOMIC LANDSCAPE OF GLIOBLASTOMA (GBM)
TMOD-02. A MODEL OF THE INITIATION AND GENOMIC LANDSCAPE OF GLIOBLASTOMA (GBM) Open
IDH-wildtype GBM is the most common variant of this cancer and occurs in older adults. Unfortunately patients’ tumors are either inherently resistant to standard treatment, which includes radio- and chemo-therapy, or acquire resistance dur…