Carmen D Mathmann
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View article: TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation Open
View article: Myddosomes in Toll‐like receptor signaling—one to bind and rule them all
Myddosomes in Toll‐like receptor signaling—one to bind and rule them all Open
Toll‐like receptors (TLRs) are innate immune sensors for the presence of pathogens and endogenous danger signals. TLR activation results in conserved intracellular signaling events that orchestrate inflammation and antimicrobial defense. W…
View article: SPATIOTEMPORAL REGULATION OF RP105 SUBCELLULAR LOCALIZATION SHAPES ENDOSOMAL TLR4 SIGNALING
SPATIOTEMPORAL REGULATION OF RP105 SUBCELLULAR LOCALIZATION SHAPES ENDOSOMAL TLR4 SIGNALING Open
Innate immune sensing of microbial and endogenous ligands by Toll-like receptor (TLR) 4 drives inflammation and antimicrobial mechanisms. While critical for host defense against pathogens, unchecked TLR4 activation causes organ damage and …