Carmen J. E. Pee
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View article: A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in <i>Mycobacterium abscessus</i>
A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in <i>Mycobacterium abscessus</i> Open
Summary Mycobacterium abscessus pulmonary disease (Mabs-PD) presents a significant and growing global health threat, particularly in individuals with underlying lung conditions like cystic fibrosis and chronic obstructive pulmonary disease…
View article: An optimized cyclophosphamide-treated mouse model of <i>Mycobacterium abscessus</i> pulmonary infection
An optimized cyclophosphamide-treated mouse model of <i>Mycobacterium abscessus</i> pulmonary infection Open
Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the nee…
View article: Designer broad-spectrum polyimidazolium antibiotics
Designer broad-spectrum polyimidazolium antibiotics Open
Significance We designed and synthesized antimicrobial compounds effective in killing pan-drug-resistant bacterial pathogens. These compounds have a large therapeutic window due to their low mammalian cell toxicity. A lead compound showed …
View article: A FASII Inhibitor Prevents Staphylococcal Evasion of Daptomycin by Inhibiting Phospholipid Decoy Production
A FASII Inhibitor Prevents Staphylococcal Evasion of Daptomycin by Inhibiting Phospholipid Decoy Production Open
Daptomycin is a treatment of last resort for serious infections caused by drug-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus . We have shown recently that S. aureus can evade daptomycin by releasing…
View article: A FASII inhibitor prevents staphylococcal evasion of daptomycin by inhibiting phospholipid decoy production
A FASII inhibitor prevents staphylococcal evasion of daptomycin by inhibiting phospholipid decoy production Open
Daptomycin is a treatment of last resort for serious infections caused by drug-resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus . We have shown recently that S. aureus can evade daptomycin by releasing …