Chuen‐Yen Lau
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View article: Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies
Derivation and external validation of community-acquired pneumonia subphenotypes in Southeast Asia: a secondary analysis of prospective cohort studies Open
Supported by US NIH awards T32HL007287, F32HL168809, K08HL157562, U01AI115520, R01AI137111, R01GM114029, R21AI173435, R01HL113382, the Wellcome Trust grants 090219/Z/09/Z, 101103/Z/13/Z, 106680/B/14/Z, and 106698/B/14/Z, the US National Ca…
View article: 751 A Treatise on the Employment of Hepatocyte Transplantation in Infantile Liver Disease: A Systematic Review
751 A Treatise on the Employment of Hepatocyte Transplantation in Infantile Liver Disease: A Systematic Review Open
Aim The escalating incidence of liver disease in non-responsive paediatric cases prompts a shift towards alternative innovative surgical treatments. Traditional orthotopic liver transplantation (OLT) faces challenges with delays and donor …
View article: Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With <scp>HIV</scp> on Antiretroviral Therapy
Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With <span>HIV</span> on Antiretroviral Therapy Open
Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [ 11 C]DASB po…
View article: P-487. [18F]-labeled J3 Nanobody is a Specific PET Tracer for Molecular Imaging of HIV-1 gp120
P-487. [18F]-labeled J3 Nanobody is a Specific PET Tracer for Molecular Imaging of HIV-1 gp120 Open
Background Targeted molecular imaging of HIV-1 can potentially identify viral reservoirs and provide a better understanding of disease pathogenesis and management. Nanobody-based radiolabeled probes offer several advantages over full antib…
View article: PET/CT guided tuberculosis treatment shortening: a randomized trial
PET/CT guided tuberculosis treatment shortening: a randomized trial Open
Six months of chemotherapy using current agents is standard of care for pulmonary, drug-sensitive tuberculosis (TB), even though some are believed to be cured more rapidly and others require longer therapy. Understanding what factors deter…
View article: Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus
Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus Open
Background Cardiovascular disease (CVD) and neuroinflammation are thought to exacerbate neurocognitive dysfunction in treated people with human immunodeficiency virus (PWH). Here, we longitudinally measured brain glucose metabolism as a me…
View article: Clinical characteristics of enteric fever and performance of TUBEX TF IgM test in Indonesian hospitals
Clinical characteristics of enteric fever and performance of TUBEX TF IgM test in Indonesian hospitals Open
Background Accurate diagnosis of enteric fever is challenging, particularly in low- and middle-income countries, due to the overlap of clinical and laboratory features with other pathogens. To better understand the difficulties in enteric …
View article: White and Gray Matter Changes are Associated With Neurocognitive Decline in <scp>HIV</scp> Infection
White and Gray Matter Changes are Associated With Neurocognitive Decline in <span>HIV</span> Infection Open
Objective To investigate the relationship between neurocognitive deficits and structural changes on brain magnetic resonance imaging in people living with HIV (PLWH) with good virological control on combination antiretroviral therapy, comp…
View article: 30.2 In Practice: Building and Maintaining Preparedness for a Rapid Research Response in Indonesia
30.2 In Practice: Building and Maintaining Preparedness for a Rapid Research Response in Indonesia Open
Existing international research partnerships, bilateral or multilateral, are a crucial building block of research response preparedness. The long-standing partnership between the Indonesia Ministry of Health and the U.S. National Institute…
View article: Advances and Challenges in Molecular Imaging of Viral Infections
Advances and Challenges in Molecular Imaging of Viral Infections Open
Molecular imaging of viral infection, using a variety of advanced imaging techniques such as optical and nuclear imaging, can and has been used for direct visualization of the virus as well as assessment of virus-host interactions. Unlike …
View article: Development of a multiassay algorithm (MAA) to identify recent HIV infection in newly diagnosed individuals in Indonesia
Development of a multiassay algorithm (MAA) to identify recent HIV infection in newly diagnosed individuals in Indonesia Open
Ongoing HIV transmission is a public health priority in Indonesia. We developed a new multiassay algorithm (MAA) to identify recent HIV infection. The MAA is a sequential decision tree based on multiple biomarkers, starting with CD4+ T cel…
View article: Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia
Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia Open
Background Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistan…
View article: Neurocognitive Dysfunction With Neuronal Injury in People With HIV on Long-Duration Antiretroviral Therapy
Neurocognitive Dysfunction With Neuronal Injury in People With HIV on Long-Duration Antiretroviral Therapy Open
BACKGROUND AND OBJECTIVES: Neurologic outcomes in people with HIV (PWH) on long-duration antiretroviral therapy (ART) are not fully understood, and the underlying pathophysiology is unclear. To address this, we established a cohort of such…
View article: Editorial: Reviews in: Radiopharmaceuticals in nuclear medicine
Editorial: Reviews in: Radiopharmaceuticals in nuclear medicine Open
EDITORIAL article Front. Med., 15 March 2023Sec. Nuclear Medicine Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1178528
View article: Malignancy and viral infections in Sub-Saharan Africa: A review
Malignancy and viral infections in Sub-Saharan Africa: A review Open
The burden of malignancy related to viral infection is increasing in Sub-Saharan Africa (SSA). In 2018, approximately 2 million new cancer cases worldwide were attributable to infection. Prevention or treatment of these infections could re…
View article: Performance of Xpert MTB/RIF and sputum microscopy compared to sputum culture for diagnosis of tuberculosis in seven hospitals in Indonesia
Performance of Xpert MTB/RIF and sputum microscopy compared to sputum culture for diagnosis of tuberculosis in seven hospitals in Indonesia Open
Introduction Tuberculosis (TB) is a major public health concern in Indonesia, where the incidence was 301 cases per 100,000 inhabitants in 2020 and the prevalence of multi-drug resistant (MDR) TB is increasing. Diagnostic testing approache…
View article: Characteristics of Drug-sensitive and Drug-resistant Tuberculosis Cases among Adults at Tuberculosis Referral Hospitals in Indonesia
Characteristics of Drug-sensitive and Drug-resistant Tuberculosis Cases among Adults at Tuberculosis Referral Hospitals in Indonesia Open
As Indonesia’s rifampin resistance testing rates are lower than global testing rates per the 2020 WHO global tuberculosis (TB) report, prevalence of multidrug-resistant TB may be underestimated. Our study aimed to evaluate prevalence and p…
View article: Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption
Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption Open
Background HIV persistence during antiretroviral therapy (ART) is the principal obstacle to cure. Lymphoid tissue is a compartment for HIV, but mechanisms of persistence during ART and viral rebound when ART is interrupted are inadequately…
View article: Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study
Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study Open
National Institutes of Health, Wellcome Trust.
View article: Retinal Thinning in People With Well-Controlled HIV Infection
Retinal Thinning in People With Well-Controlled HIV Infection Open
Background: Retinal measurements correlate with disease progression in patients with multiple sclerosis; however, whether they associate with neurologic disease in people with controlled HIV is unknown. Using spectral domain optical cohere…
View article: Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study
Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study Open
Objective To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach. Design ‘Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)’ study was an o…
View article: Editorial: COVID and Tropical Diseases – Intersection of Policy and Science
Editorial: COVID and Tropical Diseases – Intersection of Policy and Science Open
EDITORIAL article Front. Trop. Dis, 26 May 2022Sec. Disease Prevention and Control Policy https://doi.org/10.3389/fitd.2022.861715
View article: Coinfection With SARS-CoV-2 and Dengue Virus: A Case Report Highlighting Diagnostic Challenges
Coinfection With SARS-CoV-2 and Dengue Virus: A Case Report Highlighting Diagnostic Challenges Open
Background Since its emergence in China, SARS-CoV-2 has infected more than 240 million people worldwide, including in regions where dengue virus (DENV) is hyperendemic such as Latin America and Southeast Asia, including Indonesia. Diagnosi…
View article: A Coordinated Public Health Laboratory Response to COVID-19 in Mali
A Coordinated Public Health Laboratory Response to COVID-19 in Mali Open
Ability to rapidly and accurate diagnose pathogens during disease outbreaks is essential for public health. Diagnosis depends largely on laboratory capacity, which can be challenging in resource limited settings. We report Mali’s experienc…
View article: Data set - Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment score (qSOFA) in patients hospitalized with suspected infection in southeast Asia.
Data set - Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment score (qSOFA) in patients hospitalized with suspected infection in southeast Asia. Open
This is a part of prospective observational (non-interventional) study of community-acquired sepsis and severe sepsis in Sunpasithiprasong Hospital, Ubon Ratchathani province, northeast Thailand (NCT02217592; Ubon-sepsis cohort) and a mult…
View article: Sharia (Islamic Law) Perspectives of COVID-19 Vaccines
Sharia (Islamic Law) Perspectives of COVID-19 Vaccines Open
The Coronavirus disease 2019 (COVID-19) pandemic has caused health, economic, and social challenges globally. Under these circumstances, effective vaccines play a critical role in saving lives, improving population health, and facilitating…