Carmen María Aránzazu Cejudo Cortés
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View article: Exacerbation of absence seizures by central prolactin in female taiep rats: An animal model of epilepsy-prone leukodystrophy
Exacerbation of absence seizures by central prolactin in female taiep rats: An animal model of epilepsy-prone leukodystrophy Open
View article: Andrographolide Mitigates Inflammation and Reverses UVB-Induced Metabolic Reprogramming in HaCaT Cells
Andrographolide Mitigates Inflammation and Reverses UVB-Induced Metabolic Reprogramming in HaCaT Cells Open
Andrographolide (AP), a bioactive compound from Andrographis paniculata, is known for its anti-inflammatory and antioxidant properties, both essential for wound healing. However, its effects on energy metabolism during tissue repair and it…
View article: Mecanismos fisiopatológicos de las crisis de ausencia en modelos animales
Mecanismos fisiopatológicos de las crisis de ausencia en modelos animales Open
Las crisis de ausencia son un tipo de epilepsia generalizada caracterizada por una breve pérdida de conciencia y descargas espiga-onda en el electroencefalograma. Estas crisis resultan de una disfunción en el sistema GABAérgico, donde una …
View article: Prolactin Increases Spike-Wave Discharges in the Estrogenized Female Taiep Rat: An Animal Model of Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum
Prolactin Increases Spike-Wave Discharges in the Estrogenized Female Taiep Rat: An Animal Model of Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum Open
View article: Low-yawning had higher depression-like pattern in the forced swim test than high-yawning male rats: Role of androgens and fluoxetine
Low-yawning had higher depression-like pattern in the forced swim test than high-yawning male rats: Role of androgens and fluoxetine Open
View article: Eficacia y seguridad del uso de opioides en dolor crónico no oncológico: resultados de la encuesta del grupo de trabajo de opioides de la Sociedad Española de Dolor. Estudio DELPHI
Eficacia y seguridad del uso de opioides en dolor crónico no oncológico: resultados de la encuesta del grupo de trabajo de opioides de la Sociedad Española de Dolor. Estudio DELPHI Open
View article: Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a–5 Chronic Kidney Disease
Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a–5 Chronic Kidney Disease Open
Background and Objectives: Uric acid (UA) and the markers of mineral bone metabolism and inflammation are commonly altered in patients with chronic kidney disease (CKD) and are associated with the risk of cardiovascular complications and d…
View article: Differences in memory performance: The effects of sex and reproductive experience on object recognition memory in high- and low-yawning Sprague‒Dawley rats
Differences in memory performance: The effects of sex and reproductive experience on object recognition memory in high- and low-yawning Sprague‒Dawley rats Open
The novel object recognition (NOR) test is an efficient way to measure nonspatial memory in rodents. The NOR performance of female and male rats is sexually dimorphic because memory performance is better in the former than in the latter. I…
View article: Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation
Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation Open
Linoleic acid (LA), the primary ω-6 polyunsaturated fatty acid (PUFA) found in the epidermis, plays a crucial role in preserving the integrity of the skin’s water permeability barrier. Additionally, vegetable oils rich in LA have been show…
View article: 4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum
4-aminopyridine improves evoked potentials and ambulation in the taiep rat: A model of hypomyelination with atrophy of basal ganglia and cerebellum Open
The taiep rat is a tubulin mutant with an early hypomyelination followed by progressive demyelination of the central nervous system due to a point mutation in the Tubb4a gene. It shows clinical, radiological, and pathological signs like th…
View article: Characterization of sperm motility and testosterone secretion in the taiep myelin mutant, a model of demyelination
Characterization of sperm motility and testosterone secretion in the taiep myelin mutant, a model of demyelination Open
Presently, demyelinating diseases have been reported to affect the reproductive life of patients who suffer from them, but the progression of the alterations is unknown, especially in men. To better understand these effects, it is necessar…
View article: H-ABC tubulinopathy revealed by label-free second harmonic generation microscopy
H-ABC tubulinopathy revealed by label-free second harmonic generation microscopy Open
Hypomyelination with atrophy of the basal ganglia and cerebellum is a recently described tubulinopathy caused by a mutation in the tubulin beta 4a isoform, expressed in oligodendrocytes. The taiep rat is the only spontaneous tubulin beta 4…
View article: 0134 Circadian variation of absence seizures in an animal model of human leukodystrophy (H-ABC)
0134 Circadian variation of absence seizures in an animal model of human leukodystrophy (H-ABC) Open
Introduction Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a human leukodystrophy is due to a mutation in the tubulin b 4a (TUBB4A) and the taiep rats is the only available model of this human disease with sim…
View article: 0262 Sleep-wake cycle circadian disruption after chronic alcohol intake in a rat model of anxiety
0262 Sleep-wake cycle circadian disruption after chronic alcohol intake in a rat model of anxiety Open
Introduction Alcohol intake can produce disruptions in sleep-wake cycle, including circadian alterations like phase shifts. Alcohol intake is increased in subjects with anxiety to diminish its symptoms. We have selectively bred two subline…
View article: 0280 Orexins play a dual role in immobility episodes on taiep rats a model of H-ABC
0280 Orexins play a dual role in immobility episodes on taiep rats a model of H-ABC Open
Introduction Leukodystrophies are a heterogenous group of congenital myelin alterations with more than 30 classified diseases was described until now. Among them there are several mutations in the a and b tubulins the so called tubulinopha…
View article: Dificultades económicas y acceso al empleo en el tránsito a la vida adulta de la juventud con medida administrativa de protección
Dificultades económicas y acceso al empleo en el tránsito a la vida adulta de la juventud con medida administrativa de protección Open
La juventud en protección se emancipa en un contexto de vulnerabilidad. En este sentido, la disposición de medios económicos es determinante para lograr la ansiada autonomía, así como un adecuado bienestar personal. Partiendo de ello, el …
View article: Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae)
Phenolic Profile, Antioxidant and Enzyme Inhibition Properties of the Chilean Endemic Plant Ovidia pillopillo (Gay) Meissner (Thymelaeaceae) Open
Ovidia pillopillo (Lloime) is an endemic species of the Valdivian Forest of Chile. Little is known on the chemistry and biological activity of this plant. In this study, the phenolic profile, antioxidant capacities and enzyme inhibition ca…
View article: Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model Open
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a central neurodegenerative disease due to mutations in the tubulin beta-4A (TUBB4A) gene, characterized by motor development delay, abnormal movements, ataxia, sp…
View article: MOOC como disrupción educativa. Propuestas de mejora a partir del análisis de una web
MOOC como disrupción educativa. Propuestas de mejora a partir del análisis de una web Open
En este período de tiempo transcurrido desde que surgieron los MOOC se ha producido una gran difusión y evolución que los cursos actuales. La diversidad de tipos conduce a que se establezcan diferencias entre ellos en términos tales como l…
View article: Análisis de la percepción del estudiante universitario sobre el contexto sociotecnológico a través de la innovación didáctica
Análisis de la percepción del estudiante universitario sobre el contexto sociotecnológico a través de la innovación didáctica Open
Introducción. En el presente artículo se presenta un estudio diacrónico en el que se analizan 405 concepciones de estudiantes universitarios sobre la Sociedad de la Información implementadas a través de un software social (Word Clouds). Ob…
View article: The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis
The deficiency of myelin in the mutant taiep rat induces a differential immune response related to protection from the human parasite Trichinella spiralis Open
Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs. Taiep had an initial hypomyelination followed by a progressive demyelination asso…
View article: Chemical Fingerprinting and Biological Evaluation of the Endemic Chilean Fruit Greigia sphacelata (Ruiz and Pav.) Regel (Bromeliaceae) by UHPLC-PDA-Orbitrap-Mass Spectrometry
Chemical Fingerprinting and Biological Evaluation of the Endemic Chilean Fruit Greigia sphacelata (Ruiz and Pav.) Regel (Bromeliaceae) by UHPLC-PDA-Orbitrap-Mass Spectrometry Open
Greigia sphacelata (Ruiz and Pav.) Regel (Bromeliaceae) is a Chilean endemic plant popularly known as “quiscal” and produces an edible fruit consumed by the local Mapuche communities named as “chupón”. In this study, several metabolites in…
View article: MRI Features in a Rat Model of H-ABC Tubulinopathy
MRI Features in a Rat Model of H-ABC Tubulinopathy Open
Tubulinopathies are a group of recently described diseases characterized by mutations in the tubulin genes. Mutations in TUBB4A produce diseases such as dystonia type 4 (DYT4) and hypomyelination with atrophy of the basal ganglia an…
View article: Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry
Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry Open
Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae) is a shrubby or often arborescent cactus popularly known as "sancayo" and produce an edible fruit known as "Sanky" which is consumed in Arequipa-Perú. The pur…
View article: The lack of myelin in the mutant<i>taiep</i>rat induces a differential immune response related to protection to the human parasite<i>Trichinella spiralis</i>
The lack of myelin in the mutant<i>taiep</i>rat induces a differential immune response related to protection to the human parasite<i>Trichinella spiralis</i> Open
Taiep rat is a myelin mutant with a progressive motor syndrome characterized by tremor, ataxia, immobility episodes, epilepsy and paralysis of the hindlimbs, accompanied with differential expression of interleukins and their receptors that…
View article: 0428 Taiep Rats Had Normal Levels of Orexin Neurons in the Lateral Hypothalamus But Their Cataplexy Attacks are Sensible to Specific Orexin B Agonist
0428 Taiep Rats Had Normal Levels of Orexin Neurons in the Lateral Hypothalamus But Their Cataplexy Attacks are Sensible to Specific Orexin B Agonist Open
Introduction Narcolepsy is characterized by sleep fragmentation, sleep paralysis, hypnagogic hallucinations and cataplexy. The cataplexy is a sudden loss of muscle tone triggered by emotions in humans, as well as in animal models. It is st…
View article: 0427 Bicuculine Increased the Cataplexy in the Male Taiep Rats: An Animal Model of Narcolepsy with an Inherent Tubulopathy
0427 Bicuculine Increased the Cataplexy in the Male Taiep Rats: An Animal Model of Narcolepsy with an Inherent Tubulopathy Open
Introduction Narcolepsy is a hypersomnolence that is characterized by sleep fragmentation, sleep paralysis, hypnagogic hallucinations and cataplexy that is characterized by atonia induced by strong emotions. The amygdala is the trigger for…
View article: Yawning and Penile Erection Frequencies Are Resilient to Maternal Care Manipulation in the High-Yawning Subline of Sprague–Dawley Rats
Yawning and Penile Erection Frequencies Are Resilient to Maternal Care Manipulation in the High-Yawning Subline of Sprague–Dawley Rats Open
Yawning is a stereotyped behavioral pattern characterized by wide opening of the mouth associated with deep inspiration followed by short expiration. All vertebrate species yawn, but with low frequencies. We obtained two sublines of Spragu…
View article: Brain Processing of Complex Geometric Forms in a Visual Memory Task Increases P2 Amplitude
Brain Processing of Complex Geometric Forms in a Visual Memory Task Increases P2 Amplitude Open
We study the cognitive processing of visual working memory in three different conditions of memory load and configuration change. Altering this features has been shown to alter the brain’s processing in memory tasks. Most studies dealing w…
View article: Las conexiones entre apoyo familiar, escolar y el compromiso de los estudiantes en un centro de compensación educativa//The connections between family support, school and the engagement of th students in a compensatory education school
Las conexiones entre apoyo familiar, escolar y el compromiso de los estudiantes en un centro de compensación educativa//The connections between family support, school and the engagement of th students in a compensatory education school Open
RESUMEN El compromiso de los estudiantes con el aprendizaje y la escuela es el principal reto para aquellos centros en cuya misión está la integración escolar de alumnos con antecedentes de fracaso escolar. Los hallazgos precedentes subray…