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View article: #2594 Complement system evaluation in blood group incompatible living donor kidney transplantation
#2594 Complement system evaluation in blood group incompatible living donor kidney transplantation Open
Background and Aims Blood group incompatible living donor kidney transplantation (ABO-iLKT) may allow expanding the living donor pool up to 10%–30%, although a high-risk rejection exists due to anti-blood group antibodies (isoagglutinins) …
View article: Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia
Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia Open
Introduction Our objective was to evaluate the endothelial function profile and complement system in fetuses from preeclamptic pregnancies using ex vivo and in vitro approaches. Material and Methods A total of 66 singleton pregnancies were…
View article: Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia
Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia Open
Background Preeclampsia (PE) is a pregnancy complication characterized by hypertension, proteinuria, endothelial dysfunction, and complement dysregulation. Placenta-derived extracellular vesicles (EVs), necessary in maternal–fetal communic…
View article: Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease
Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease Open
Background Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been…
View article: Antithrombotic and prohemorrhagic actions of different concentrations of apixaban in patients exposed to single and dual antiplatelet regimens
Antithrombotic and prohemorrhagic actions of different concentrations of apixaban in patients exposed to single and dual antiplatelet regimens Open
We evaluated modifications in the hemostatic balance of different concentrations of apixaban (APIX) in 25 healthy donors and 53 patients treated with aspirin (ASA, n = 21), ASA and clopidogrel (ASA + CLOPI, n = 11), or ASA and ticagrelor (…
View article: Easix Score Correlates With Endothelial Dysfunction Biomarkers and Predicts Risk of Acute Graft-Versus-Host Disease After Allogeneic Transplantation
Easix Score Correlates With Endothelial Dysfunction Biomarkers and Predicts Risk of Acute Graft-Versus-Host Disease After Allogeneic Transplantation Open
View article: Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications
Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications Open
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humo…
View article: PB1422 Differential Expression of Proteins from Cultured Endothelial Cells Exposed to Serum from Patients with Acute Graft versus Host Disease Sensitive or Refractory to Corticosteroid Treatment
PB1422 Differential Expression of Proteins from Cultured Endothelial Cells Exposed to Serum from Patients with Acute Graft versus Host Disease Sensitive or Refractory to Corticosteroid Treatment Open
View article: PB1510 Circulating Extracellular Vesicles and Neutrophil Extracellular Traps Contribute to Endothelial Dysfunction in Pregnant Women with Preeclampsia
PB1510 Circulating Extracellular Vesicles and Neutrophil Extracellular Traps Contribute to Endothelial Dysfunction in Pregnant Women with Preeclampsia Open
Table 1: Interval-specific likelihood ratios with 95%CI at different aPS/PT titer ranges for OAPS compared to the control population.Conclusion(s): aPS/PT IgG and IgM were associated with OAPS diagnosis, but without added value compared to…
View article: EP18.13: Circulating extracellular vesicles contribute to endothelial dysfunction in pregnant women with pre‐eclampsia
EP18.13: Circulating extracellular vesicles contribute to endothelial dysfunction in pregnant women with pre‐eclampsia Open
To investigate the contribution of placenta-derived extracellular vesicles (pdEVs) in pre-eclampsia (PE) associated endothelial dysfunction. Sera samples from 8 PE and 6 normotensive pregnancies were pooled in 3 PE pools and 1 control pool…
View article: OC 10.5 Endotheliopathy, Innate-Immune Activation and Hemostatic Imbalance Underlying CAR -T Cell Toxicities: Tools for Early and Differential Diagnosis
OC 10.5 Endotheliopathy, Innate-Immune Activation and Hemostatic Imbalance Underlying CAR -T Cell Toxicities: Tools for Early and Differential Diagnosis Open
View article: OC 25.5 Endothelial Damage and Complement Dysregulation in Fetuses from Mothers with Preeclampsia
OC 25.5 Endothelial Damage and Complement Dysregulation in Fetuses from Mothers with Preeclampsia Open
View article: PB0779 NETs and Terminal Complement Pathway as Potential Biomarkers for Complement Overactivation Assessment in ANCA-Associated Vasculitis
PB0779 NETs and Terminal Complement Pathway as Potential Biomarkers for Complement Overactivation Assessment in ANCA-Associated Vasculitis Open
Background: Extracellular traps (ETs) formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability.A key mechanism during NET formation is histone modification by the enzym…
View article: Differential protein expression in endothelial cells exposed to serum from patients with acute graft‐vs‐host disease, depending on steroid response
Differential protein expression in endothelial cells exposed to serum from patients with acute graft‐vs‐host disease, depending on steroid response Open
Graft‐versus‐host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury is crucial as pathophysiological substrate for GVHD. GVHD first‐line treatment is high‐dose corticosteroids, although …
View article: Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis
Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis Open
Background Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated n…
View article: Antithrombotic and Prohemorrhagic Actions of Different Concentrations of Apixaban in Patients Exposed to Single and Dual Antiplatelet Regimens
Antithrombotic and Prohemorrhagic Actions of Different Concentrations of Apixaban in Patients Exposed to Single and Dual Antiplatelet Regimens Open
BACKGROUND: Treatment with triple antithrombotic therapies increases bleeding risks. AIM: We evaluated the antithrombotic and prohemorrhagic actions of different concentrations of apixaban (APIX) in healthy donors and patients exposed to c…
View article: Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development
Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development Open
This work aims to review the role of endothelial dysfunction underlying the main complications appearing early after autologous and allogeneic hematopoietic cell transplantation (HCT). The endothelial damage as the pathophysiological subst…
View article: Mafosfamide, a Cyclophosphamide Analog, Causes a Proinflammatory Response and Increased Permeability on Endothelial Cells in Vitro
Mafosfamide, a Cyclophosphamide Analog, Causes a Proinflammatory Response and Increased Permeability on Endothelial Cells in Vitro Open
Post-transplantation cyclophosphamide (PTCy) has decreased GVHD incidence. Endothelial damage in allo-HCT is caused by multiple factors, including conditioning treatments and some immunosupressants, and underlies HCT-complications as GVHD.…
View article: Complement Mediated Endothelial Damage in Thrombotic Microangiopathies
Complement Mediated Endothelial Damage in Thrombotic Microangiopathies Open
Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a common underlying mechanism: the endothelial damage. These disorders may exhibit different mechanisms of endothelial injury depending on the pathologi…
View article: Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy Open
View article: The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics
The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics Open
Introduction: Preeclampsia is a multi-system disorder unique to pregnancy responsible for a great part of maternal and perinatal morbidity and mortality. The precise pathogenesis of this complex disorder is still unrevealed. Methods: We ex…
View article: OC15.06: *Endothelial damage and inflammation cell signalling triggered by pre‐eclampsia versus COVID‐19 in pregnancy
OC15.06: *Endothelial damage and inflammation cell signalling triggered by pre‐eclampsia versus COVID‐19 in pregnancy Open
To study endothelial damage and alteration in signalling pathways in endothelial cells exposed to sera from pregnant women with PE and COVID-19 in vitro. Sera samples were obtained from pregnant women with COVID-19 infection classified int…
View article: VP31.03: Endotheliopathy biomarkers and angiogenic factors in distinguishing pre‐eclampsia from COVID‐19 in pregnancy
VP31.03: Endotheliopathy biomarkers and angiogenic factors in distinguishing pre‐eclampsia from COVID‐19 in pregnancy Open
To explore the performance of endotheliopathy biomarkers and angiogenic factors in distinguishing pre-eclampsia (PE) from COVID-19 in pregnancy. Plasma and sera samples were obtained from pregnant women with COVID-19 infection (n = 18) and…
View article: OC15.07: Distinctive endothelial and angiogenic signature of pre‐eclampsia versus COVID‐19 in pregnancy
OC15.07: Distinctive endothelial and angiogenic signature of pre‐eclampsia versus COVID‐19 in pregnancy Open
To study endothelial damage, microvascular thrombosis, immune response and angiogenic imbalance in pre-eclampsia (PE) and COVID-19 in pregnancy. Plasma and sera samples were obtained from pregnant women with COVID-19 infection classified i…
View article: The importance of endothelial protection: the emerging role of defibrotide in reversing endothelial injury and its sequelae
The importance of endothelial protection: the emerging role of defibrotide in reversing endothelial injury and its sequelae Open
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS), a potentially life-threatening complication of hematopoietic cell transplantation (HCT), results from prolonged sinusoidal endothelial cell activation and profound e…
View article: Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?
Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications? Open
View article: Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes
Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes Open
Given the critical role of endothelial dysfunction in numerous infectious syndromes, in particular COVID-19, therapeutic pharmacology for these conditions should increasingly prioritize endothelial stabilization. Several agents with endoth…
View article: Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics
Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics Open
View article: Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing
Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing Open
CD19‐directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B‐cell malignancies, specially in B‐cell acute lymphoblastic leukemia (B‐ALL). However, CAR T‐cell‐treated patients eventually …
View article: Defibrotide for the Treatment of Endotheliitis Complicating Sars-Cov-2 Infection: Rationale and Ongoing Studies As Part of the International Defacovid Study Group
Defibrotide for the Treatment of Endotheliitis Complicating Sars-Cov-2 Infection: Rationale and Ongoing Studies As Part of the International Defacovid Study Group Open
Coronavirus disease 2019 (COVID-19) is a heterogeneous clinical condition caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The initial stage of infection occurs at the time of respiratory viral invasion thr…