Carmen Villmann
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View article: Distinct Epitopes Are Associated With Clinical Phenotypes in Autoimmune Nodopathies With Anti-Contactin1 Autoantibodies
Distinct Epitopes Are Associated With Clinical Phenotypes in Autoimmune Nodopathies With Anti-Contactin1 Autoantibodies Open
Our findings highlight the heterogeneity of anti-contactin1 nodopathies, suggesting that distinct epitope-binding patterns may underlie different clinical manifestations and may be associated with different pathogenic mechanisms and comorb…
View article: Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern
Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern Open
Infection with SARS-CoV-2 continues to be a threat to human health. Despite successful immunization campaigns, effective treatment of COVID-19 remains an essential need to help patients and prevent the spread of new virus strains. Viropori…
View article: Binding patterns of glycine receptor autoantibodies are related to clinical syndromes
Binding patterns of glycine receptor autoantibodies are related to clinical syndromes Open
View article: Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease Open
View article: Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system
Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system Open
Introduction: Essential oils (EOs) are complex mixtures with different application areas in human medicine and health. Some harbor calming and anxiolytic effects, which has been attributed to GABAA receptor (GABAAR) modulation. Although GA…
View article: Neuropathic Pain and Distinct CASPR2 Autoantibody IgG Subclasses Drive Neuronal Hyperexcitability
Neuropathic Pain and Distinct CASPR2 Autoantibody IgG Subclasses Drive Neuronal Hyperexcitability Open
IgG4 aAbs seem to be the major modifier of potassium channel function. The DRG hyperexcitability is primarily due to impaired Kv channel conductance as a consequence of CASPR2 aAb binding. However, additional unidentified signal pathways c…
View article: Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes
Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes Open
Glycine receptors (GlyRs) are typically known for mediating inhibitory synaptic transmission within the spinal cord and brainstem, but they also have key roles in embryonic brain development, learning/memory, inflammatory pain sensitizatio…
View article: 3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology
3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology Open
Glioblastoma multiforme is the most devastating brain tumor without cure. Although in vitro and in vivo research on glioblastoma multiforme have demonstrated its complexity, including interactions with brain cells and the tumor microenviro…
View article: Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies
Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies Open
In summary, our study is the first to implicate presynaptic defects in the pathophysiology of autoimmune diseases such as SPS and PERM, which are associated with GlyR aAbs. Individually tuned binding preferences for presynaptic and postsyn…
View article: Streamlining the Highly Reproducible Fabrication of Fibrous Biomedical Specimens toward Standardization and High Throughput
Streamlining the Highly Reproducible Fabrication of Fibrous Biomedical Specimens toward Standardization and High Throughput Open
Soft nano‐ and microfiber‐based polymer scaffolds bear enormous potential for their use in cell culture and tissue engineering since they mimic natural collagen structures and may thus serve as biomimetic adhesive substrates. They have, ho…
View article: Impact of Polymorphic Microfibers for Establishment of Neuronal Model
Impact of Polymorphic Microfibers for Establishment of Neuronal Model Open
The biological and mechanical environment of cells is better mimicked in 3D compared to 2D cell cultures. However, creating accurate 3D cell culture models particularly for ultra‐soft tissues like brain or spinal cord is challenging since …
View article: Case report: target antigen and subclass switch in a patient with autoimmune nodopathy
Case report: target antigen and subclass switch in a patient with autoimmune nodopathy Open
Introduction Autoimmune nodopathy (AN) is a new entity in the field of peripheral neuropathies and is defined by the presence of auto-antibodies against structures of the node of Ranvier combined with specific clinico-pathophysiological fe…
View article: Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability
Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability Open
Patients with autoantibodies (aAbs) against the contactin-associated protein-like 2 (CASPR2) suffer from a variety of clinical syndromes including neuropathic pain, in some patients even as the only symptom. CASPR2 is an adhesion protein o…
View article: Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies
Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies Open
A possible potentiating effect of pathogenic GlyR antibodies together with T cells directed against neurons may have led to the severe and progressive clinical course.
View article: Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene Open
View article: Breast Tumor Cell Survival and Morphology in a Brain‐like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties
Breast Tumor Cell Survival and Morphology in a Brain‐like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties Open
Triple‐negative breast cancer (TNBC) is the most invasive type of breast cancer with high risk of brain metastasis. To better understand interactions between breast tumors with the brain extracellular matrix (ECM), a 3D cell culture model …
View article: Author response: 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
Author response: 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase Open
View article: 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…
View article: Reviewer #1 (Public Review): 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
Reviewer #1 (Public Review): 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…
View article: 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…
View article: Author response: 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
Author response: 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase Open
View article: Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity
Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity Open
Introduction Subgroups of autoantibodies directed against voltage-gated potassium channel (K v ) complex components have been associated with immunotherapy-responsive clinical syndromes. The high prevalence and the role of autoantibodies d…
View article: Streamlining the highly reproducible fabrication of fibrous biomedical specimens towards standardization and high throughput
Streamlining the highly reproducible fabrication of fibrous biomedical specimens towards standardization and high throughput Open
Nano- and micro-fiber-based scaffolds bear enormous potential for their use in cell culture and tissue engineering, since they mimic natural collagen structures and may thus serve as biomimetic adhesive substrates. They have, however, so f…
View article: Different pain phenotypes are associated with anti-Caspr2 autoantibodies
Different pain phenotypes are associated with anti-Caspr2 autoantibodies Open
View article: Glycine Receptor β–Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases
Glycine Receptor β–Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases Open
Our study establishes GlyRβ as novel target of aAb in patients with SPS/PERM. In contrast to exclusively GlyRα1-positive sera, which alter glycine potency, aAbs against GlyRβ impair receptor efficacy for the neurotransmitter glycine. Imagi…
View article: 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…
View article: 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…
View article: Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease
Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease Open
Startle disease is due to the disruption of recurrent inhibition in the spinal cord. Most common causes are genetic variants in genes ( GLRA1 , GLRB ) encoding inhibitory glycine receptor (GlyR) subunits. The adult GlyR is a heteropentamer…
View article: Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human Pathologies, Human Startle Disease, and Developmental Delay
Dual Role of Dysfunctional Asc-1 Transporter in Distinct Human Pathologies, Human Startle Disease, and Developmental Delay Open
Human startle disease is associated with mutations in distinct genes encoding glycine receptors, transporters or interacting proteins at glycinergic synapses in spinal cord and brainstem. However, a significant number of diagnosed patients…
View article: 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase Open
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation im…