Carmine Vecchione
YOU?
Author Swipe
View article: MicroRNA Signatures in Cardiometabolic Disorders as a Next-Generation Diagnostic Approach: Current Insight
MicroRNA Signatures in Cardiometabolic Disorders as a Next-Generation Diagnostic Approach: Current Insight Open
Cardiometabolic diseases, including cardiovascular disorders and type 2 diabetes mellitus, are the leading cause of morbidity and mortality worldwide, placing a significant burden on healthcare systems. Although advances in imaging and ris…
View article: Unraveling the Risk Factors for Type II Diabetes in severe Obese patients with indication for Bariatric Surgery: retrospective analysis.
Unraveling the Risk Factors for Type II Diabetes in severe Obese patients with indication for Bariatric Surgery: retrospective analysis. Open
View article: BAG3 concentrations and heart failure events among individuals undergoing coronary and peripheral angiography
BAG3 concentrations and heart failure events among individuals undergoing coronary and peripheral angiography Open
To investigate the circulating BAG3 role as a biomarker across Universal Definition of Heart Failure (UDHF) stages, plasma samples from 1121 individuals undergoing coronary and/or peripheral angiography across UDHF stages were analyzed usi…
View article: In vivo evidence supports the effectiveness of the longevity-associated protein LAV-BPIFB4 in reducing adipose tissue-derived mediators of systemic inflammation to prevent vascular insult and atheromatous change
In vivo evidence supports the effectiveness of the longevity-associated protein LAV-BPIFB4 in reducing adipose tissue-derived mediators of systemic inflammation to prevent vascular insult and atheromatous change Open
Obesity triggers chronic low-grade inflammation contributing to cardiovascular and metabolic diseases. Over-release of adipokines and pro-inflammatory mediators by white adipose tissue (WAT) enhances inflammation through a feedforward loop…
View article: Diagnostic Accuracy of Coronary CT Angiography in Ruling Out Significant Coronary Artery Disease in Candidates for Transcatheter Aortic Valve Replacement
Diagnostic Accuracy of Coronary CT Angiography in Ruling Out Significant Coronary Artery Disease in Candidates for Transcatheter Aortic Valve Replacement Open
Obstructive coronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve implantation (TAVI). While invasive coronary angiography (ICA) is the gold standard for coronary evaluation, coronary computed tomography…
View article: Mindfulness-Based Interventions for Chronic Pulmonary Diseases: A Systematic Review of Effects on Anxiety, Depression, Stress, Dyspnea, and Quality of Life
Mindfulness-Based Interventions for Chronic Pulmonary Diseases: A Systematic Review of Effects on Anxiety, Depression, Stress, Dyspnea, and Quality of Life Open
(1) Background: Chronic pulmonary diseases (CPDs), such as COPD, asthma, and interstitial lung disease, are often accompanied by psychological distress and reduced quality of life. Mindfulness-Based Interventions (MBIs), including digital …
View article: Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure: Design and Rationale of the TELEREHAB-HF Study
Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure: Design and Rationale of the TELEREHAB-HF Study Open
Background: Despite strong guideline recommendations, participation in cardiac rehabilitation (CR) among patients with chronic heart failure (CHF) remains low due to logistical, geographical, and psychosocial barriers. Telerehabilitation m…
View article: Functional Mitral Regurgitation in the Transcatheter Era: Diagnostic and Therapeutic Pathways
Functional Mitral Regurgitation in the Transcatheter Era: Diagnostic and Therapeutic Pathways Open
Functional mitral regurgitation (FMR) is a common condition with significant prognostic implications, primarily driven by left atrial or ventricular remodeling secondary to ischemic or non-ischemic cardiomyopathies. While guideline-directe…
View article: Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction
Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction Open
View article: Cardiovascular Nursing in Rehabilitative Cardiology: A Review
Cardiovascular Nursing in Rehabilitative Cardiology: A Review Open
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, necessitating comprehensive management and prevention strategies. Rehabilitative cardiology, also known as cardiac rehabilitation (CR), is a multidisciplinary …
View article: TRIB1: a multifaceted regulator of cardiometabolic health
TRIB1: a multifaceted regulator of cardiometabolic health Open
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. The rising prevalence of CVD is primarily driven by several risk factors, including dyslipidemia, atherosclerosis, diabetes, and obesity. Many curre…
View article: Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems
Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems Open
Neurogenesis is considered the most robust form of plasticity in the adult brain. To better decipher this process, we evaluated the potential crosstalk of Kisspeptin and Endocannabinoid Systems (KPS and ECS, respectively) on hippocampal ne…
View article: Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients
Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients Open
View article: Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC)
Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC) Open
The benefits of cardiac rehabilitation (CR) have been demonstrated in patients after myocardial infarction (MI), and in patients with chronic heart failure (HF). The core components of the CR program include improvement in exercise toleran…
View article: From Planning to Practice: Impact of Achieved Proximal Sealing Zone in Endovascular Aneurysm Repair (EVAR)
From Planning to Practice: Impact of Achieved Proximal Sealing Zone in Endovascular Aneurysm Repair (EVAR) Open
Background: Endovascular aneurysm repair (EVAR) is the preferred treatment for abdominal aortic aneurysms (AAAs). This study evaluated the differences between the anticipated and actual achieved proximal sealing zones for standard EVAR end…
View article: Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link?
Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link? Open
Cardiometabolic and cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with well-established risk factors such as smoking, obesity, and diabetes contributing to plaque formation and chronic inflammation. However, e…
View article: Retrospective Study on Short-Term Reverse Cardiac Remodeling in Obese Patients Undergoing Sleeve Gastrectomy
Retrospective Study on Short-Term Reverse Cardiac Remodeling in Obese Patients Undergoing Sleeve Gastrectomy Open
Severe obesity is closely associated with an increased risk of comorbidities and alterations in cardiac structure and function. The primary objective of this study was to investigate cardiovascular (CV) risk factors and ventricular remodel…
View article: The effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better
The effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better Open
View article: Do Not Mix It up! Long-Term Outcomes of Different Proximal Aortic Cuffs with the AFX Endograft
Do Not Mix It up! Long-Term Outcomes of Different Proximal Aortic Cuffs with the AFX Endograft Open
Combining endografts from different manufacturers, especially those with differing materials and sealing mechanisms, may compromise the long-term integrity of certain EVAR repairs. Clinicians should exercise caution when considering mixed-…
View article: Plasma miR‐1‐3p levels predict severity in hospitalized COVID‐19 patients
Plasma miR‐1‐3p levels predict severity in hospitalized COVID‐19 patients Open
Background and Purpose Accumulating evidence suggests circulating microRNAs (miRNAs) are important regulators of biological processes involved in COVID‐19 complications. We sought to assess whether circulating miRNAs are associated with CO…
View article: Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry
Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry Open
Background The clinical relevance of cardiac troponin (cTn) elevation in takotsubo syndrome (TTS) remains uncertain. The present study sought to investigate the role of cardiac troponin (cTn) elevations in mortality prediction of patients …
View article: Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons
Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons Open
Methamphetamine (METH) is a drug of abuse, which induces behavioral sensitization following repeated doses. Since METH alters blood pressure, in the present study we assessed whether systolic and diastolic blood pressure (SBP and DBP, resp…
View article: An explainable model for predicting Worsening Heart Failure based on genetic programming
An explainable model for predicting Worsening Heart Failure based on genetic programming Open
Heart Failure (HF) poses a challenge for our health systems, and early detection of Worsening HF (WHF), defined as a deterioration in symptoms and clinical and instrumental signs of HF, is vital to improving prognosis. Predicting WHF in a …
View article: Temporal Trends in Takotsubo Syndrome
Temporal Trends in Takotsubo Syndrome Open
This study of temporal trends in TTS highlights a transition in patients demographic with a growing prevalence among men, increasing recognition of midventricular TTS type, and increased short-term mortality and rates of cardiogenic shock …
View article: SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug?
SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug? Open
View article: Novel targets and strategies addressing residual cardiovascular risk in post-acute coronary syndromes patients
Novel targets and strategies addressing residual cardiovascular risk in post-acute coronary syndromes patients Open
Despite the advancement in secondary cardiovascular prevention strategies for post-acute coronary syndrome (ACS) patients, the development of new drugs addressing dyslipidemia and the personalization of dual antiplatelet therapies (DAPT), …
View article: Clinical utility of TRBC1 addition in multiparametric flow cytometry for T cell lymphoma diagnosis
Clinical utility of TRBC1 addition in multiparametric flow cytometry for T cell lymphoma diagnosis Open
Diagnosis of T cell lymphoproliferative disorders requires one or multiple immunophenotypic aberrations, histological tissue structure or composition modifications, and T cell clonality demonstration. Here, we present two T cell lymphoma c…
View article: Role of Mechanical Circulatory Support in Complex High-Risk and Indicated Percutaneous Coronary Intervention: Current Indications, Device Options, and Potential Complications
Role of Mechanical Circulatory Support in Complex High-Risk and Indicated Percutaneous Coronary Intervention: Current Indications, Device Options, and Potential Complications Open
Improved expertise and technological advancements have enabled the safe and effective performance of complex and high-risk-indicated percutaneous coronary intervention (CHIP) in patients previously considered inoperable or high-risk. Mecha…
View article: Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review
Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review Open
Background: Cardiovascular diseases (CVDs) are associated with very high rates of re-hospitalization and mortality worldwide, so the complexity of these pathologies requires frequent access to hospital facilities. The guidelines also empha…
View article: The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets
The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets Open
Beyond their activity in hemostasis and thrombosis, recent advances attribute platelets a pro-youthful role capable to attenuate immune senescence and age-related neuroinflammation. Previous studies from our group associated a polymorphic …