Yang Chen
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Coal Tar Pitch Preoxidation-Impregnation Regulates Pore Distribution to Prepare Porous Carbon for Electrochemistry Open
Enhancing the performance of porous carbon materials has become a key focus in current research. In this study, oxygen-containing functional groups were introduced into the carbon skeleton to improve its properties. Air preoxidation can no…
Efficient Tetracycline Adsorption by KOH-Activated Yak-Dung Biochar: Mechanistic Insights Open
In this study, yak dung was used as a precursor to prepare biochar (KYBC600) via high-temperature pyrolysis and KOH modification for the adsorption of tetracycline hydrochloride (TCH) from aqueous solution. Compared with commonly used biom…
View article: A nomogram based on coagulation markers for predicting meige syndrome risk
A nomogram based on coagulation markers for predicting meige syndrome risk Open
Background Meige syndrome (MS) is a rare adult-onset cranial dystonia associated with complex neuropathological mechanisms. Recent studies have shown that abnormal coagulation plays a vital role in the pathological and physiological mechan…
DEAD-box helicase gcDDX56 disrupts IRF3 nuclear import complex and promotes nuclear IRF3 degradation for enhancing GCRV replication Open
DEAD-box helicases play multifaceted roles in antiviral immunity, acting as both viral sensors and regulators of interferon (IFN) signaling. However, the role of DDX56 in teleost antiviral immunity remains poorly characterized. This study …
Efficacy and safety of bruton tyrosine kinase (BTK) inhibitor zanubrutinib in relapsed/refractory warm autoimmune hemolytic anemia (wAIHA) after multiple lines of therapy: A prospective phase 2 single-arm study Open
Objective: To evaluate the efficacy and safety of the Bruton tyrosine kinase (BTK) inhibitor zanubrutinib in patients with relapsed/refractory (R/R) wAIHA who had failed at least two prior lines of immunosuppressive therapy. Methods: This …
View article: Divergent Sensitization Kinetics to Indoor Allergens in Children: Early Dust Mite Surges vs Delayed Cat Dander Peaks During COVID-19 Lockdowns
Divergent Sensitization Kinetics to Indoor Allergens in Children: Early Dust Mite Surges vs Delayed Cat Dander Peaks During COVID-19 Lockdowns Open
National Medical Research Registration Information System/MR-44-24-056093.
Target trial emulation of DPP-4 Inhibitors in patients with T2DM for pulmonary tuberculosis: a nationwide observational data Open
In patients with T2DM, the use of DPP-4 inhibitors was associated with a significantly lower risk of developing pulmonary TB compared to non-use. Additionally, a longer cumulative duration of DPP-4 inhibitor may further reduce the TB risk.
View article: Preparation of ZnCl2-Activated Magnetic Biochar and Its Performance in Removing Hexavalent Chromium from Water
Preparation of ZnCl2-Activated Magnetic Biochar and Its Performance in Removing Hexavalent Chromium from Water Open
Magnetic biochar (Zn/Fe-BC) was prepared from jujube branches via an impregnation pyrolysis–coprecipitation technique to eliminate Cr(VI) from water. ZnFe2O4 was introduced through ZnCl2-based impregnation and pyrolysis, which can regulate…
View article: Introducing LongCat-Flash-Thinking: A Technical Report
Introducing LongCat-Flash-Thinking: A Technical Report Open
We present LongCat-Flash-Thinking, an efficient 560-billion-parameter open-source Mixture-of-Experts (MoE) reasoning model. Its advanced capabilities are cultivated through a meticulously crafted training process, beginning with long Chain…
View article: miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma
miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma Open
Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their …
Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma Open
Valemetostat is a dual inhibitor of EZH2/1 approved in Japan for the treatment of relapsed/refractory (R/R) adult T–cell lymphoma/leukemia (ATLL) and R/R peripheral T–cell lymphoma (PTCL). It is administered orally once daily (QD) at 200 m…
View article: Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue
Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Microenvironmental Remodeling in Human Ureteral Scar Stricture Tissue Open
This study presents the first high-resolution single-cell atlas of ureteral scar stricture tissue, revealing profound cellular heterogeneity and remodeling of the immune-stromal-epithelial landscape. The findings also highlight intensified…
View article: A Survey of Data Security Sharing
A Survey of Data Security Sharing Open
In the digital era, secure data sharing has become a core requirement for enabling cross-domain collaboration, cloud computing, and Internet of Things (IoT) applications, as well as a critical measure for safeguarding privacy and defending…
View article: SUMO proteases SPF1/2 inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1
SUMO proteases SPF1/2 inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1 Open
Seed filling and fatty acid biosynthesis are critical processes for seed development and oil accumulation in plants, regulated by intricate post-translational mechanisms. Here, we elucidate the molecular mechanism by which SUMO proteases S…
Prevalence of low-level viremia in people living with HIV/AIDS and its impact on virological failure in Guizhou Province, China Open
Background The frequency of low-level viremia (LLV) may vary across China. This study aims to analyze the epidemiological characteristics and related factors of LLV among HIV/AIDS patients in Guizhou Province from 2016 to 2022, and further…
Specific binding of human P[28] rotavirus VP8* protein to blood group ABH antigens on type 1 chains Open
Group A rotavirus (RV) has been the major cause of acute gastroenteritis in infants and young children. Among the five P genogroups almost all P genotype RVs in P[II], P[III] and P[IV] genogroups that infect humans can bind glycan histo-bl…
Different Perceptual Mechanism of Categorizing Emotional Faces in Depression and Schizophrenia Open
Background: Emotional stimuli affect basic and cognitive operations, such as perception, attention and memory and changes in emotional perception are associated with various mental disorders. Changes in emotional perception are associated …
View article: Chicory inulin efficacy and metabolic mechanism in piglet-derived lactic acid bacteria: Unveiling the synbiotic potential of Lactiplantibacillus plantarum YT640 and inulin
Chicory inulin efficacy and metabolic mechanism in piglet-derived lactic acid bacteria: Unveiling the synbiotic potential of Lactiplantibacillus plantarum YT640 and inulin Open
Chicory-derived fermentable dietary fiber, Orafti® Inulin, is considered as a prebiotic in animal husbandry. This study investigated the fermentative capabilities of 308 lactic acid bacteria strains, obtained from fecal samples of healthy …
View article: Mitigating microstructural heterogeneity in laser-directed energy deposition Ni-based superalloys by heat accumulation in-situ heat treatment
Mitigating microstructural heterogeneity in laser-directed energy deposition Ni-based superalloys by heat accumulation in-situ heat treatment Open
The microstructure and mechanical properties of additively manufactured (AM) components often exhibit inherent heterogeneity due to their complex thermal histories. Building on conventional heat treatment strategies to mitigate microstruct…
Polygonati kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, often associated with dysregulated immune responses, gut barrier dysfunction, and microbial imbalance. In this study, a novel polysaccharide…
CAR-T cell therapy clinical trials: global progress, challenges, and future directions from ClinicalTrials.gov insights Open
Chimeric antigen receptor T (CAR-T) cell therapy has undergone vigorous development in recent years, yet it still faces significant challenges and difficulties in its clinical application and further development. A systematic synthesis of …
Activation of Persulfates Using Alkali-Modified Activated Coke to Promote Phenol Removal Open
Coke (AC) was modified and activated with sodium hydroxide (NaOH) and potassium hydroxide (KOH) to produce AC-Na and AC-K, respectively, and applied as a persulfate (PS) activator to promote phenol (Ph) removal in water. Under the given ex…