Explanipedia

Atrophy of the optic chiasm is associated with microvascular diabetic complications in type 1 diabetes Open

Aleksi Tarkkonen, Tor-björn Claesson, Marika I. Eriksson, Carol Forsblom, Lena M. Thorn , et al. · 2023

Introduction Diabetic neuropathy and diabetic eye disease are well known complications of type 1 diabetes. We hypothesized that chronic hyperglycemia also damages the optic tract, which can be measured using routine magnetic resonance imag…

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease Open

Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri , et al. · 2023

Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover m…

The impact of diabetic nephropathy and severe diabetic retinopathy on chronic limb threatening ischemia risk in individuals with type 1 diabetes: a nationwide, population study Open

Valma Harjutsalo, Milla Kallio, Carol Forsblom, Per‐Henrik Groop · 2023

Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes Open

Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sørine Birkelund, Anna Syreeni , et al. · 2023

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic v…

Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease Open

Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner , et al. · 2022

Type 1 diabetes affects over nine million individuals globally, with approximately 40% developing diabetic kidney disease. Emerging evidence suggests that epigenetic alterations, such as DNA methylation, are involved in diabetic kidney dis…

Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations Open

Niina Sandholm, Ronja Hotakainen, Jani K. Haukka, Fanny Jansson Sigfrids, Emma H. Dahlström , et al. · 2022

Background Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the standard lipid measurements, apolipoprotein concentrations provide added awa…

Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and mortality in type 1 diabetes Open

Heli Segersvärd, Carol Forsblom, Niina Sandholm, Valma Harjutsalo, Riikka Kosonen , et al. · 2022

Background/Introduction Heme oxygenase-1 (HO-1), encoded by the HMOX1 gene is a highly inducible enzyme with multiple cardiovascular protective properties. Polymorphisms of the HMOX1 gene, especially a guanine-thymine dinucleotide repeat p…

Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes Open

Anna Syreeni, Emma H. Dahlström, Stefanie Hägg-Holmberg, Carol Forsblom, Marika I. Eriksson , et al. · 2022

The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between haptoglobin Hp1/2 genotype and stroke in i…

Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes Open

Anna Syreeni, Emma H. Dahlström, Stefanie Hägg-Holmberg, Carol Forsblom, Marika I. Eriksson , et al. · 2022

The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between haptoglobin Hp1/2 genotype and stroke in i…

Haptoglobin Genotype Does Not Confer a Risk of Stroke in Type 1 Diabetes Open

Anna Syreeni, Emma H. Dahlström, Stefanie Hägg-Holmberg, Carol Forsblom, Marika I. Eriksson , et al. · 2022

The exon copy number variant in the haptoglobin gene is associated with cardiovascular and kidney disease. For stroke, previous research is inconclusive. We aimed to study the relationship between the haptoglobin Hp1/2 genotype and stroke …

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease Open

Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu , et al. · 2022

Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previo…

Effects of Butyrate Supplementation on Inflammation and Kidney Parameters in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial Open

Ninna Hahn Tougaard, Marie Frimodt‐Møller, Hanne Salmenkari, Elisabeth B. Stougaard, Andressa de Zawadzki , et al. · 2022

Type 1 diabetes is associated with increased intestinal inflammation and decreased abundance of butyrate-producing bacteria. We investigated the effect of butyrate on inflammation, kidney parameters, HbA1c, serum metabolites and gastrointe…

Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open

Christine P. Limonte, Erkka Valo, Viktor R. Drel, Loki Natarajan, Manjula Darshi , et al. · 2022

Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…

Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open

Christine P. Limonte, Erkka Valo, Viktor R. Drel, Loki Natarajan, Manjula Darshi , et al. · 2022

OBJECTIVE Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS We performed a case-control stud…

Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open

Christine P. Limonte, Erkka Valo, Viktor R. Drel, Loki Natarajan, Manjula Darshi , et al. · 2022

Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…

IDF21-0464 The role of central obesity for progression of diabetic nephropathy in type 1 diabetes Open

Erika B. Parente, Stefan Mutter, Erkka Valo, Lena M. Thorn, Carol Forsblom , et al. · 2022

Effect of serum sample storage temperature on metabolomic and proteomic biomarkers Open

Erkka Valo, Marco Colombo, Niina Sandholm, Stuart J. McGurnaghan, Luke A. K. Blackbourn , et al. · 2022

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum Open

Per‐Henrik Groop, Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo , et al. · 2022

Objective : Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). L-type calcium channel blockers (LTCCBs) have been widely used as antihypertensive medication (AHM), but their association with VEGF and D…

Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes Open

Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom , et al. · 2022

OBJECTIVE Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD) calling for early interventions. This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to esta…

Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes Open

Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom , et al. · 2022

OBJECTIVE Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD) calling for early interventions. This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to esta…

Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes Open

Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom , et al. · 2022

OBJECTIVE Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD), calling for early interventions. This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to est…

Response to Comment on Parente et al. The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes. Diabetes Care 2021;44:1706–1713 Open

Erika B. Parente, Emma H. Dahlström, Valma Harjutsalo, Jussi Inkeri, Stefan Mutter , et al. · 2021

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum Open

Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius , et al. · 2021

Objective Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). L-type calcium channel blockers (LTCCBs) have been widely used as antihypertensive medication (AHM), but their association with VEGF and DR …

Apolipoprotein C‐III predicts cardiovascular events and mortality in individuals with type 1 diabetes and albuminuria Open

Fanny Jansson Sigfrids, Lars Stechemesser, Emma H. Dahlström, Carol Forsblom, Valma Harjutsalo , et al. · 2021

Objectives We studied apolipoprotein C‐III (apoC‐III) in relation to diabetic kidney disease (DKD), cardiovascular outcomes, and mortality in type 1 diabetes. Methods The cohort comprised 3966 participants from the prospective observationa…

Glycemic control is not related to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes Open

Jussi Inkeri, Krishna Adeshara, Valma Harjutsalo, Carol Forsblom, Ron Liebkind , et al. · 2021

Aims To determine if medium- and long-term blood glucose control as well as glycemic variability, which are known to be strong predictors of vascular complications, are associated with underlying cerebral small vessel disease (cSVD) in neu…

Nut Consumption Is Associated with Lower Risk of Metabolic Syndrome and Its Components in Type 1 Diabetes Open

Aila J. Ahola, Carol Forsblom, Valma Harjutsalo, Per‐Henrik Groop · 2021

Although nut consumption has been associated with several health benefits, it has not been investigated in individuals with type 1 diabetes. Therefore, our aim was to assess nut consumption and its association with metabolic syndrome in ad…

Urinary metabolite profiling and risk of progression of diabetic nephropathy in 2670 individuals with type 1 diabetes Open

Stefan Mutter, Erkka Valo, Viljami Aittomäki, Kristian Nybo, Lassi Raivonen , et al. · 2021

Urine extracellular vesicles capture kidney transcriptome and hyperglycemia linked mRNA signatures for type 1 diabetic kidney disease Open

Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Rashmi B. Prasad , et al. · 2021

Diabetic kidney disease (DKD) is a severe complication of type 1 diabetes (T1D), which lacks non-invasive early biomarkers. Although less explored, mRNAs in urinary extracellular vesicles (uEV) could reflect changes in the kidney transcrip…

Urinary extracellular vesicles: Assessment of pre‐analytical variables and development of a quality control with focus on transcriptomic biomarker research Open

Karina Barreiro, Om Prakash Dwivedi, Sami Valkonen, Per‐Henrik Groop, Jaakko Tuomilehto , et al. · 2021

Urinary extracellular vesicles (uEV) are a topical source of non‐invasive biomarkers for health and diseases of the urogenital system. However, several challenges have become evident in the standardization of uEV pipelines from collection …

Genome-Wide Association Study of Peripheral Artery Disease Open

Natalie R. van Zuydam, Alexander Stiby, Moustafa Abdalla, Erin Austin, Emma H. Dahlström , et al. · 2021

Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and s…

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