Explanipedia

Epidemiology of Group B <i>Streptococcus</i>: Maternal Colonization and Infant Disease in Kampala, Uganda Open

Mary Kyohere, Hannah G Davies, Konstantinos Karampatsas, Liberty Cantrell, Philippa Musoke , et al. · 2025

Background Child survival rates have improved globally, but neonatal mortality due to infections, such as group B Streptococcus (GBS), remains a significant concern. The global burden of GBS-related morbidity and mortality is substantial. …

Interlaboratory comparison of a multiplex immunoassay that measures human serum IgG antibodies against six-group B streptococcus polysaccharides Open

Kirsty Le Doaré, Michelle Gaylord, Annaliesa S. Anderson, Nick Andrews, Carol J. Baker , et al. · 2024

Measurement of IgG antibodies against group B streptococcus (GBS) capsular polysaccharide (CPS) by use of a standardized and internationally accepted multiplex immunoassay is important for the evaluation of candidate maternal GBS vaccines …

Evolving antibiotic resistance in Group B Streptococci causing invasive infant disease: 1970–2021 Open

Elizabeth Marie Sabroske, Misu Ailin Sanson Iglesias, Marcia A. Rench, Trevor Moore, Hanna Harvey , et al. · 2022

Use of 15-Valent Pneumococcal Conjugate Vaccine Among U.S. Children: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 Open

Miwako Kobayashi, Jennifer L. Farrar, Ryan Gierke, Andrew J. Leidner, Doug Campos‐Outcalt , et al. · 2022

The 13-valent pneumococcal conjugate vaccine (PCV13 [Prevnar 13, Wyeth Pharmaceuticals, Inc, a subsidiary of Pfizer, Inc]) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23 [Merck Sharp & Dohme LLC]) have been recommended for U…

Use of whole-genome sequencing to detect transmission of group A Streptococcus in Houston, TX Open

Zain Alamarat, Misu A. Sanson, J. Chase McNeil, Carol J. Baker, Anthony R. Flores · 2022

We used a combination of local, comprehensive strain surveillance and bacterial whole-genome sequencing to identify potential transmission events of group A streptococcus (GAS) in Houston, TX, USA. We identified pharyngeal and skin and sof…

Population Genomics Reveals Distinct Temporal Association with the Emergence of ST1 Serotype V Group B Streptococcus and Macrolide Resistance in North America Open

M. Belén Cubria, Luis Alberto Vega, William C. Shropshire, Misu A. Sanson, Brittany J. Shah , et al. · 2021

Identified in the 1970s as the leading cause of invasive bacterial disease in neonates and young infants, Group B Streptococcus (GBS) is now also recognized as a significant cause of morbidity and mortality among adults with underlying med…

Complete Genome Sequence of Neonatal Clinical Group B Streptococcal Isolate CJB111 Open

Brady L. Spencer, Anushila Chatterjee, Breck A. Duerkop, Carol J. Baker, Kelly S. Doran · 2021

Group B Streptococcus (GBS) is an asymptomatic colonizer of the female reproductive tract but can cause maternal and neonatal infections and adverse pregnancy outcomes. Here, we closed the genome sequence of strain CJB111, a neonatal GBS c…

Seroepidemiology of maternally-derived antibody against Group B Streptococcus (GBS) in Mulago/Kawempe Hospitals Uganda - PROGRESS GBS Open

Mary Kyohere, Hannah G Davies, Philippa Musoke, Annettee Nakimuli, Valerie Tusubira , et al. · 2020

Background: Group B Streptococcus (GBS) is a major contributor to the high burden of neonatal and young infant infectious disease in resource- limited settings. As disease protection during the first six months of life is provided via plac…

Engaging African American breast cancer survivors in an intervention trial: culture, responsiveness and community Open

Barbara B. Germino, Merle H. Mishel, G. Rumay Alexander, Coretta Jenerette, Diane Blyler , et al. · 2020

Younger breast cancer survivors often lead extremely busy lives with multiple demands and responsibilities, making them difficult to recruit into clinical trials. African American women are even more difficult to recruit because of additio…

Seroepidemiology of maternally-derived antibody against Group B Streptococcus (GBS) in Mulago/Kawempe Hospitals Uganda - PROGRESS GBS Open

Mary Kyohere, Hannah G Davies, Philippa Musoke, Annettee Nakimuli, Valerie Tusubira , et al. · 2020

Background : Group B Streptococcus (GBS) is a major contributor to the high burden of neonatal and young infant infectious disease in resource- limited settings. As disease protection during the first six months of life is provided via pl…

1483. Maternal Tdap Vaccination During Pregnancy and Immune Response: A Comparison Between Infants Born to Mothers Primed with Acellular or Whole Cell Pertussis Vaccines Open

Fiona P. Havers, Tami H. Skoff, Marcia A. Rench, Monica Epperson, Jarad Schiffer , et al. · 2020

Background Acellular pertussis (aP) vaccines replaced whole cell pertussis (wP) vaccines for the recommended childhood primary series in the United States in 1997. As women primed with aP vaccines in childhood enter reproductive age, it is…

Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of <i>Escherichia coli</i>, and the Need for Novel Prevention Strategies Open

Barbara J. Stoll, Karen M. Puopolo, Nellie I. Hansen, Pablo J. Sánchez, Edward F. Bell , et al. · 2020

In this study, EOS incidence and associated mortality disproportionately occurred in preterm infants. Contemporary cases have demonstrated the limitations of current GBS prevention strategies. The increase in E coli infections among very l…

2902. Pertussis Antibody Levels in Preterm Infants After Maternal Tdap Immunization During Pregnancy Open

Catherine Healy, Marcia A. Rench, Laurie S. Swaim, Gowrisankar Rajam, Fiona P. Havers , et al. · 2019

Background Maternal immunization with tetanus, diphtheria, acellular pertussis vaccine (Tdap) in the third trimester reduces infant pertussis, but data are lacking on how this strategy impacts pertussis antibody levels in large cohorts of …

855. Evolution of Group B Streptococcal Capsular Type V Invasive Infections in Neonates and Young Infants: A Whole Genome Sequencing Study Open

Anthony R. Flores, Misu A. Sanson, Brittany J. Shah, Marcia A. Rench, Samuel A. Shelburne , et al. · 2019

Background Since 1970 group B Streptococcus (GBS) has been a frequent cause of sepsis or meningitis in young infants. Capsular polysaccharide type V was first recognized in 1990 and has increased to the point where it now causes ~15% of GB…

Vaccines for maternal immunization against Group B Streptococcus disease: WHO perspectives on case ascertainment and case definitions Open

Anna C. Seale, Carol J. Baker, James A. Berkley, Shabir A. Madhi, Jaume Ordï , et al. · 2019

The role of immune correlates of protection on the pathway to licensure, policy decision and use of group B Streptococcus vaccines for maternal immunization: considerations from World Health Organization consultations Open

Johan Vekemans, Jonathan Crofts, Carol J. Baker, David Goldblatt, Paul T. Heath , et al. · 2019

The development of a group B Streptococcus (GBS) vaccine for maternal immunization constitutes a global public health priority, to prevent GBS-associated early life invasive disease, stillbirth, premature birth, maternal sepsis, adverse ne…

50 Years Ago in T J P Open

Carol J. Baker, Sarah S. Long · 2019

Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration Open

Catherine Healy, Marcia A. Rench, Laurie S. Swaim, E. O’Brian Smith, Haleh Sangi‐Haghpeykar , et al. · 2018

Immunization with Tdap vaccine during the third trimester of pregnancy, compared with no immunization, was associated with higher neonatal concentrations of pertussis toxin antibodies. Immunization early in the third trimester was associat…

A Phase 2, Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide-tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization With GBS III Open

Sharon L. Hillier, Patricia Ferrieri, Morven S. Edwards, Marian Ewell, Daron Ferris , et al. · 2018

Background Group B Streptococcus (GBS) frequently colonizes pregnant women and can cause sepsis and meningitis in young infants. If colonization was prevented through maternal immunization, a reduction in perinatal GBS disease might be pos…

Maternal immunization against Group B streptococcus: World Health Organization research and development technological roadmap and preferred product characteristics Open

Johan Vekemans, Vasee Moorthy, Martin Friede, Mark R. Alderson, Ajoke Sobanjo-ter Meulen , et al. · 2018

Prevalence and Capsular Types of Group B Streptococci Colonizing Indian Women Living in the United States Open

Manu Chaudhary, Marcia A. Rench, Anuja Vyas, Anthony R. Flores, Carol J. Baker , et al. · 2017

Group B streptococcal rectovaginal colonization prevalence in women of Indian descent living in the United States was 24.7% comparable with US rates but higher than rates reported from India. The capsular polysaccharide types were distinct…

Risk of Early-Onset Neonatal Group B Streptococcal Disease With Maternal Colonization Worldwide: Systematic Review and Meta-analyses Open

Neal Russell, Anna C. Seale, Catherine O’Sullivan, Kirsty Le Doaré, Paul T. Heath , et al. · 2017

The risk of EOGBS among GBS-colonized pregnant women, from this first systematic review, is consistent with previous estimates from single studies (1%-2%). Increasing IAP coverage was linearly associated with decreased risk of EOGBS diseas…

Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses Open

Neal Russell, Anna C. Seale, Megan O’Driscoll, Catherine O’Sullivan, Fiorella Bianchi-Jassir , et al. · 2017

Incidence data on maternal GBS disease in developing regions are lacking. In developed regions the incidence is low, as are the sequelae for the mother, but the risk to the fetus and newborn is substantial. The timing of GBS disease sugges…

Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review Open

Kirsty Le Doaré, Megan O’Driscoll, Kim Turner, Farah Seedat, Neal Russell , et al. · 2017

There is considerable heterogeneity in IAP screening policies and coverage worldwide. Alternative global strategies, such as maternal vaccination, are needed to enhance the scope of global prevention of GBS disease.

Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis Open

Cally J Tann, Kathryn A. Martinello, Samantha Sadoo, Joy E Lawn, Anna C. Seale , et al. · 2017

The consistent increased proportion of GBS disease in NE and significant increased risk of mortality provides evidence that GBS infection contributes to NE. Increased information regarding this and other organisms is important to inform in…

Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children: Why, What, and How to Undertake Estimates? Open

Joy E Lawn, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch, Cally J Tann , et al. · 2017

Improving maternal, newborn, and child health is central to Sustainable Development Goal targets for 2030, requiring acceleration especially to prevent 5.6 million deaths around the time of birth. Infections contribute to this burden, but …

Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta-analyses Open

Maya Kohli-Lynch, Neal Russell, Anna C. Seale, Ziyaad Dangor, Cally J Tann , et al. · 2017

BACKGROUND: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of GBS disease…

Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children Open

Anna C. Seale, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch, Cally J Tann , et al. · 2017

Our conservative estimates suggest that GBS is a leading contributor to adverse maternal and newborn outcomes, with at least 409000 (UR, 144000-573000) maternal/fetal/infant cases and 147000 (UR, 47000-273000) stillbirths and infant deaths…

Stillbirth With Group B Streptococcus Disease Worldwide: Systematic Review and Meta-analyses Open

Anna C. Seale, Hannah Blencowe, Fiorella Bianchi-Jassir, Nicholas D. Embleton, Quique Bassat , et al. · 2017

GBS is likely an important cause of stillbirth, especially in Africa. However, data are limited in terms of geographic spread, with no data from Asia, and cases worldwide are probably underestimated due to incomplete case ascertainment. Mo…

Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses Open

Jennifer Hall, Nadine Hack Adams, Linda Bartlett, Anna C. Seale, Theresa Lamagni , et al. · 2017

BACKGROUND: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. METHODS…

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