Carol L. Kinlough
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View article: Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis
Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis Open
View article: Influence of MUC1 on trafficking of TRPV5 and TRPV6 and<i>in vivo</i>Ca<sup>2+</sup>homeostasis
Influence of MUC1 on trafficking of TRPV5 and TRPV6 and<i>in vivo</i>Ca<sup>2+</sup>homeostasis Open
SUMMARY Polymorphism of the gene encoding mucin 1 ( MUC1 ) is associated with skeletal and dental phenotypes in human genomic studies. Animals lacking MUC1 exhibit mild reduction in bone density. These phenotypes could be a consequence of …
View article: KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury Open
KIM-1 plays a key role in the recovery of the tubule epithelium during renal IRI by mediating efferocytosis and associated signaling that suppresses inflammation. Excessive cleavage of KIM-1 by ADAM17 provides a decoy receptor that aggrava…
View article: KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury Open
Cell-associated kidney injury molecule-1 (KIM-1) exerts an anti-inflammatory role following kidney injury by mediating efferocytosis and downregulating the NF-κB pathway. KIM-1 cleavage blunts its anti-inflammatory activities. We reported …
View article: Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation
Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation Open
Although type-2-induced (T2-induced) epithelial dysfunction is likely to profoundly alter epithelial differentiation and repair in asthma, the mechanisms for these effects are poorly understood. A role for specific mucins, heavily N-glycos…
View article: Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension
Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension Open
View article: <i>N</i>-linked glycans are required on epithelial Na<sup>+</sup>channel subunits for maturation and surface expression
<i>N</i>-linked glycans are required on epithelial Na<sup>+</sup>channel subunits for maturation and surface expression Open
Epithelial Na + channel (ENaC) subunits undergo N-linked glycosylation in the endoplasmic reticulum where they assemble into an αβγ complex. Six, 13, and 5 consensus sites (Asn-X-Ser/Thr) for N-glycosylation reside in the extracellular dom…
View article: Author Index
Author Index Open
View article: Regulation of the epithelial Na+ channel by paraoxonase-2
Regulation of the epithelial Na+ channel by paraoxonase-2 Open
Paraoxonase-2 (PON-2) is a membrane-bound lactonase with unique anti-oxidative and anti-atherosclerotic properties. PON-2 shares key structural elements with MEC-6, an endoplasmic reticulum-resident molecular chaperone in Caenorhabditis…
View article: Author Index
Author Index Open
View article: Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel
Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel Open
The epithelial sodium channel (ENaC) has an important role in regulating extracellular fluid volume and blood pressure, as well as airway surface liquid volume and mucociliary clearance. ENaC is a trimer of three homologous subunits (α, β,…
View article: Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury
Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury Open
The hypoxia-inducible factor (HIF)-1 and β-catenin protective pathways represent the two most significant cellular responses that are activated in response to acute kidney injury. We previously reported that murine mucin (Muc)1 protects ki…
View article: Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain
Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain Open
The extracellular regions of epithelial Na(+) channel subunits are highly ordered structures composed of domains formed by α helices and β strands. Deletion of the peripheral knuckle domain of the α subunit in the αβγ trimer results in cha…
View article: RhoB-dependent modulation of early endocytic traffic in Madin-Darby canine kidney cells.
RhoB-dependent modulation of early endocytic traffic in Madin-Darby canine kidney cells. Open
This article was withdrawn by the authors before final publication on September 16, 2004.