Yi‐Chun Liu
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View article: Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy
Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy Open
Sequential cancer therapy presents a critical challenge, as the impact of prior treatments on immunotherapy remains unclear. Here, we demonstrate that therapeutic stress from prolonged cetuximab exposure induces tumor-intrinsic resistance …
View article: Cellular senescence links severe Leptospira infection to chronic kidney disease progression
Cellular senescence links severe Leptospira infection to chronic kidney disease progression Open
Severe Leptospira infection drives maladaptive kidney repair through senescence and fibrosis, promoting CKD progression. Targeting cellular senescence may represent a promising strategy to prevent chronic renal damage after leptospirosis.
View article: Microtie
Microtie Open
View article: Microtia
Microtia Open
View article: Supplementary Data 1 from INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Supplementary Data 1 from INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Open
Supplementary material
View article: Data from INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Data from INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Open
Purpose:Treatment options for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) after failure of immune checkpoint inhibitor treatment and platinum-based chemotherapy are limited. Preliminary data suggested that mona…
View article: Massive nasal bleeding in nasopharyngeal Carcinoma: Incidence, risk Predictors, and survival impact
Massive nasal bleeding in nasopharyngeal Carcinoma: Incidence, risk Predictors, and survival impact Open
We identified a 5.3% incidence rate of massive nasal bleeding among newly diagnosed NPC patients treated with curative RT. Skull base ORN and local recurrence were the major risk factors in predicting massive bleeding. The occurrence of ma…
View article: Biomonitoring result of PFAS exposure from Gabreski Air National Firefighting foam among residents in Westhampton, NY
Biomonitoring result of PFAS exposure from Gabreski Air National Firefighting foam among residents in Westhampton, NY Open
Background: Perfluorooctanoic sulfonic acid (PFOS) and other per- and poly-fluoroalkyl substances (PFAS) are considered emerging contaminants. The New York State Department of Health (NYSDOH) conducted a PFAS biomonitoring program for a sa…
View article: INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Open
Purpose: Treatment options for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) after failure of immune checkpoint inhibitor treatment and platinum-based chemotherapy are limited. Preliminary data suggested that mon…
View article: Speech Delay and Hearing Rehabilitation Disparities in Children With Hearing Loss
Speech Delay and Hearing Rehabilitation Disparities in Children With Hearing Loss Open
Objectives To investigate the influence of race and insurance type on speech delay rates and hearing rehabilitation access in children with bilateral hearing loss (HL). Study Design Retrospective cross‐sectional study of pediatric patients…
View article: Robotic-Assisted Colon Cancer Surgery: Faster Recovery and Less Pain Compared to Laparoscopy in a Retrospective Propensity-Matched Study
Robotic-Assisted Colon Cancer Surgery: Faster Recovery and Less Pain Compared to Laparoscopy in a Retrospective Propensity-Matched Study Open
Background and Objective: Colorectal cancer (CRC) is the third most common cancer worldwide, with colon cancer accounting for approximately 60% of all CRC cases. Surgery remains the primary and most effective treatment. Robotic-assisted su…
View article: Cold scissors ploughing technique versus electrosurgical excision for hysteroscopic adhesiolysis: a multicenter randomized controlled trial
Cold scissors ploughing technique versus electrosurgical excision for hysteroscopic adhesiolysis: a multicenter randomized controlled trial Open
Intrauterine adhesions (IUAs) may lead to abnormal menstruation, infertility, and pregnancy-related complications. Hysteroscopic separation is the gold standard treatment for IUA and can be performed using a variety of instruments and meth…
View article: Key Decision-Making Factors in Pediatric Microtia Repair
Key Decision-Making Factors in Pediatric Microtia Repair Open
View article: Uncovering latent infections in kidneys: A novel molecular approach for differential Leptospira detection
Uncovering latent infections in kidneys: A novel molecular approach for differential Leptospira detection Open
View article: Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen
Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen Open
Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world surviv…
View article: Precision Identification of Locally Advanced Rectal Cancer in Denoised CT Scans Using EfficientNet and Voting System Algorithms
Precision Identification of Locally Advanced Rectal Cancer in Denoised CT Scans Using EfficientNet and Voting System Algorithms Open
Background and objective: Local advanced rectal cancer (LARC) poses significant treatment challenges due to its location and high recurrence rates. Accurate early detection is vital for treatment planning. With magnetic resonance imaging (…
View article: Sleep Duration and Kidney Function – Does Weekend Sleep Matter?
Sleep Duration and Kidney Function – Does Weekend Sleep Matter? Open
The underlying mediators of lWD and CKD could be the dysregulation of human behaviors, metabolism, or biological functions. Longer weekend sleep duration was linked to a decrease in eGFR levels. It warrants further study to clarify the med…
View article: General anesthesia with local infiltration reduces urine retention rate and prolongs analgesic effect than spinal anesthesia for hemorrhoidectomy
General anesthesia with local infiltration reduces urine retention rate and prolongs analgesic effect than spinal anesthesia for hemorrhoidectomy Open
Introduction Postoperative pain and complications pose significant challenges following a hemorrhoidectomy. Attaining effective anesthesia with minimal complications is crucial. The ideal anesthesia method for ambulatory hemorrhoidectomy r…
View article: Bile Acid Metabolic Profiles and Their Correlation with Intestinal Epithelial Cell Proliferation and Barrier Integrity in Suckling Piglets
Bile Acid Metabolic Profiles and Their Correlation with Intestinal Epithelial Cell Proliferation and Barrier Integrity in Suckling Piglets Open
Bile acids (BAs) are crucial for maintaining intestinal epithelial homeostasis. However, the metabolic changes in BAs and the communication between intestinal epithelial cells (IECs) in infants after birth remain unclear. This study aims t…
View article: Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma Open
Importance There are currently no therapies approved by the US Food and Drug Administration for nasopharyngeal carcinoma (NPC). Gemcitabine-cisplatin is the current standard of care for the first-line treatment of recurrent or metastatic N…
View article: Myeloid Neoplasms appearing after Cytotoxic Therapy in Patients with Nasopharyngeal Carcinoma: Experience at a Single Institute
Myeloid Neoplasms appearing after Cytotoxic Therapy in Patients with Nasopharyngeal Carcinoma: Experience at a Single Institute Open
Objectives Myeloid neoplasms post cytotoxic therapy (MN-pCT) is a specific hematological disease arising after chemoradiotherapy (CRT) for a variety of primary unrelated malignancies or autoimmune diseases. MN-pCT after treatment of nasoph…
View article: 854O INTERLINK-1: Phase III study of cetuximab (CTX) ± monalizumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) with disease progression on/after platinum chemotherapy (CT) and previously treated with an immune checkpoint inhibitor (ICI)
854O INTERLINK-1: Phase III study of cetuximab (CTX) ± monalizumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) with disease progression on/after platinum chemotherapy (CT) and previously treated with an immune checkpoint inhibitor (ICI) Open
View article: [Morphological study on the transverse branch of lateral femoral circumflex artery based on digital subtraction angiography].
[Morphological study on the transverse branch of lateral femoral circumflex artery based on digital subtraction angiography]. Open
Objective: To summarize the morphological characteristics of the transverse branch of lateral femoral circumflex artery (LFCA) using digital subtraction angiography (DSA) and explore its clinical significance. Methods: A retr…
View article: Verifying the accuracy of self-reported smoking behavior in female volunteer soldiers
Verifying the accuracy of self-reported smoking behavior in female volunteer soldiers Open
View article: Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model
Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model Open
Background Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and the right drugs f…
View article: Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer
Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer Open
Background and objectives: Among patients with pathologically proven T2N0 oral squamous cell carcinoma (OSCC), a notable amount of patients still die from tumor recurrence although they have radical surgery for early stage cancers. In lite…
View article: Learning curve and surgical outcome of robotic assisted colorectal surgery with ERAS program
Learning curve and surgical outcome of robotic assisted colorectal surgery with ERAS program Open
View article: Radiomics Combined with Multiple Machine Learning Algorithms in Differentiating Pancreatic Ductal Adenocarcinoma from Pancreatic Neuroendocrine Tumor: More Hands Produce a Stronger Flame
Radiomics Combined with Multiple Machine Learning Algorithms in Differentiating Pancreatic Ductal Adenocarcinoma from Pancreatic Neuroendocrine Tumor: More Hands Produce a Stronger Flame Open
The aim of this study was to assess the diagnostic ability of radiomics combined with multiple machine learning algorithms to differentiate pancreatic ductal adenocarcinoma (PDAC) from pancreatic neuroendocrine tumor (pNET). This retrospec…
View article: Impact of antibiotic treatment for chronic endometritis on pregnancy outcomes in women with reproductive failures (RIF and RPL): A systematic review and meta-analysis
Impact of antibiotic treatment for chronic endometritis on pregnancy outcomes in women with reproductive failures (RIF and RPL): A systematic review and meta-analysis Open
Objective The aim of this study was to investigate the effect of antibiotic treatment for chronic endometritis (CE) on reproductive outcomes. Design Systematic review and meta-analysis. Patients Women with reproductive failures, including …
View article: Real-World Efficacy and Safety of Tafluprost in Primary Open-Angle Glaucoma Patients with Corneal Disorders: A Taiwan Experience
Real-World Efficacy and Safety of Tafluprost in Primary Open-Angle Glaucoma Patients with Corneal Disorders: A Taiwan Experience Open
Purpose. To investigate the efficacy and safety of switching to 0.0015% tafluprost ophthalmic solution with reduced benzalkonium chloride (BAK) on primary open-angle glaucoma (POAG) patients with corneal disorders under 0.005% latanoprost …