Carol Readhead
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View article: Derivation of embryonic stem cells across avian species
Derivation of embryonic stem cells across avian species Open
Germline-competent embryonic stem (ES) cells have been successfully derived from mice and rats, but not from other species. Here we report the development of culture conditions for deriving ES cells from chickens and seven other avian spec…
View article: Exploring non-invasive sexing of early chick embryos in intact eggs using Laser Speckle Contrast Imaging (LSCI) and Deep Neural Network (DNN)
Exploring non-invasive sexing of early chick embryos in intact eggs using Laser Speckle Contrast Imaging (LSCI) and Deep Neural Network (DNN) Open
The ability to image blood flow in early-stage avian embryos has significant applications in developmental biology, drug and vaccine testing, as well as determining sex differentiation. In this project, we used our recently developed laser…
View article: Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to nifedipine and amlodipine drugs
Automated non-invasive laser speckle imaging of the chick heart rate and extraembryonic blood vessels and their response to nifedipine and amlodipine drugs Open
Using our recently developed laser speckle contrast imaging (LSCI) to visualize blood vessels and monitor blood flow, here we test the utility of the chick embryo for drug screening. To this end, we examined the effects of antihypertensive…
View article: Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stages
Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stages Open
Imaging blood vessels in early-stage avian embryos has a wide range of practical applications for developmental biology studies, drug and vaccine testing, and early sex determination. Optical imaging, such as brightfield transmission imagi…
View article: Non-invasive laser speckle imaging of extra-embryonic blood vessels in intact few-days-old avian eggs
Non-invasive laser speckle imaging of extra-embryonic blood vessels in intact few-days-old avian eggs Open
Imaging blood vessels in early-stage avian embryos has a wide range of practical applications for developmental biology studies, drug and vaccine testing, and early sex determination. Optical imaging such as brightfield transmission imagin…
View article: Common protein-coding variants influence the racing phenotype in galloping racehorse breeds
Common protein-coding variants influence the racing phenotype in galloping racehorse breeds Open
Selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses b…
View article: Prevalence and Risk factors of Infertility in a Mongolian Population
Prevalence and Risk factors of Infertility in a Mongolian Population Open
Background: Worldwide, the median prevalence of infertility is 9%, but rates in different countries vary from 3.5% to 16.7%. Infertility, which is defined by the World Health Organization (WHO) as the failure to conceive after 12 months of…
View article: Winter Air Pollution from Domestic Coal Fired Heating in Ulaanbaatar, Mongolia, Is Strongly Associated with a Major Seasonal Cyclic Decrease in Successful Fecundity
Winter Air Pollution from Domestic Coal Fired Heating in Ulaanbaatar, Mongolia, Is Strongly Associated with a Major Seasonal Cyclic Decrease in Successful Fecundity Open
Pollution of the environment is increasing and threatens the health and wellbeing of adults and children around the globe. The impact of air pollution on pulmonary and cardiovascular disease has been well documented, but it also has a dele…
View article: Prevalence and Risk factors of Infertility in a Mongolian Population
Prevalence and Risk factors of Infertility in a Mongolian Population Open
Background Worldwide, the median prevalence of infertility is 9%, but rates in different countries vary from 3.5–16.7%. Infertility, which is defined by the World Health Organization (WHO) as the failure to conceive after 12 months of unpr…
View article: Prevalence and Risk factors of Infertility in a Mongolian Population
Prevalence and Risk factors of Infertility in a Mongolian Population Open
Background Worldwide, the median prevalence of infertility is 9%, but rates in different countries vary from 3.5–16.7%. Infertility, which is defined by the World Health Organization (WHO) as the failure to conceive after 12 months of unpr…
View article: Prevalence and Risk factors of Infertility in a Mongolian Population
Prevalence and Risk factors of Infertility in a Mongolian Population Open
Background: Worldwide, the median prevalence of infertility is 9%, but rates in different countries vary from 3.5% to 16.7%. Infertility, which is defined by the World Health Organization (WHO) as the failure to conceive after 12 months of…
View article: Mapping a multiplexed zoo of mRNA expression
Mapping a multiplexed zoo of mRNA expression Open
In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which multiple target mRNAs are mapped in a single sample, are essential for studying regulat…
View article: Combinatorial Analysis of mRNA Expression Patterns in Mouse Embryos Using Hybridization Chain Reaction
Combinatorial Analysis of mRNA Expression Patterns in Mouse Embryos Using Hybridization Chain Reaction Open
Multiplexed fluorescent hybridization chain reaction (HCR) and advanced imaging techniques can be used to evaluate combinatorial gene expression patterns in whole mouse embryos with unprecedented spatial resolution. Using HCR, DNA probes c…