Carolina García‐Vidal
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View article: The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice
The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice Open
Invasive candidiasis is a life‐threatening infection associated with high morbidity, mortality and healthcare costs in both general and critical care settings. Timely diagnosis and adequate antifungal treatment are essential to improving p…
View article: Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections
Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Pseudomonas aeruginosa Bloodstream Infections Open
Anaerobic growth of P. aeruginosa in blood cultures is an independent predictor of septic shock and 30-day mortality in patients with P. aeruginosa BSI. The potential relationship between higher bacterial load and biofilm formation in the …
View article: Viral viability markers of SARS-CoV-2: a comparison of cell culture, genomic RNA RT-PCR, and subgenomic RNA RT-PCR
Viral viability markers of SARS-CoV-2: a comparison of cell culture, genomic RNA RT-PCR, and subgenomic RNA RT-PCR Open
Accurate methods to assess viral viability are crucial for determining isolation duration and antiviral therapy in immunocompromised patients. Although cell culture (CC) is the gold standard, it has limitations. Cycle threshold (Ct) values…
View article: Risk factors for invasive mould infections in adult patients with hematological malignancies and/or stem cell transplant: A systematic literature review and meta-analysis
Risk factors for invasive mould infections in adult patients with hematological malignancies and/or stem cell transplant: A systematic literature review and meta-analysis Open
PROSPERO, CRD42023429103.
View article: Co-infections during SARS-CoV-2 infection in hematologic patients and cell therapy recipients in the omicron era: a Spanish hematopoietic stem cell transplantation and cell therapy group study
Co-infections during SARS-CoV-2 infection in hematologic patients and cell therapy recipients in the omicron era: a Spanish hematopoietic stem cell transplantation and cell therapy group study Open
SARS-CoV-2 co-infection are relatively frequent in hematologic patients and cellular therapy recipients in the Omicron era. Patients with ischemic cardiopathy, those presenting with pneumonia and recipients of CAR-T are at a higher risk of…
View article: Rectal colonization by multidrug-resistant Gram-negative bacteria and subsequent bacteraemia in haematological patients
Rectal colonization by multidrug-resistant Gram-negative bacteria and subsequent bacteraemia in haematological patients Open
Routine weekly surveillance for MDR-GNB in haematological patients enables early identification of colonization, often preceding MDR-GNB BSIs. Further studies using adjusted analyses are needed to establish its independent predictive value.
View article: Detection of septic metastases in catheter-related Staphylococcus aureus bacteremia using 18FFDG-PET/CT: a before-and-after study
Detection of septic metastases in catheter-related Staphylococcus aureus bacteremia using 18FFDG-PET/CT: a before-and-after study Open
[18F]FDG-PET/CT use in patients with CR-SAB was associated with a higher rate of septic metastases diagnosis, mainly pulmonary and osteoarticular, resulting in longer treatment, but no differences in clinical outcomes were observed.
View article: Post-Transplant Cyclophosphamide-Based Prophylaxis and Its Impact on Infectious Complications and Immune Reconstitution According to Donor Type
Post-Transplant Cyclophosphamide-Based Prophylaxis and Its Impact on Infectious Complications and Immune Reconstitution According to Donor Type Open
Background/Objectives: This study evaluated infectious complications and immune reconstitution in 253 adults undergoing peripheral blood allogeneic hematopoietic cell transplantation (allo-HCT) with post-transplant cyclophosphamide (PTCY)-…
View article: Effectiveness of pharmacological treatments for COVID-19 due to SARS-CoV-2: a systematic literature review
Effectiveness of pharmacological treatments for COVID-19 due to SARS-CoV-2: a systematic literature review Open
Aim Since the first cases of the COVID-19 pandemic, caused by the SARS-CoV-2 virus, described in 2019, numerous drugs have been proposed for the treatment of the disease. However, studies have given contradictory or inconclusive results, m…
View article: P-1030. Mortality attributable to candidemia: Results from the European Confederation of Medical Mycology Multinational Observational Cohort Study Candida III
P-1030. Mortality attributable to candidemia: Results from the European Confederation of Medical Mycology Multinational Observational Cohort Study Candida III Open
Background Despite advances in antifungals, Candida infections still have a high mortality rate of up to 40%. The ECMM Candida III study in Europe investigated the changing epidemiology and outcomes, highlighting the need to understand and…
View article: P-2288. Antibiotic Use and Infectious Complications in Hematological Patients Undergoing CAR T-Cell Therapy
P-2288. Antibiotic Use and Infectious Complications in Hematological Patients Undergoing CAR T-Cell Therapy Open
Background Patients undergoing chimeric antigen receptor (CAR) T-cell therapy face significant infection risks. Current data on the frequency and nature of these infections remain limited. Table 1 Methods Prospective multicenter cohort inc…
View article: Novel PiuC, PirA, and PiuA mutations leading to <i>in vivo</i> cefiderocol resistance progression in IMP-16- and KPC-2-producing <i>Pseudomonas aeruginosa</i> from a leukemic patient
Novel PiuC, PirA, and PiuA mutations leading to <i>in vivo</i> cefiderocol resistance progression in IMP-16- and KPC-2-producing <i>Pseudomonas aeruginosa</i> from a leukemic patient Open
Pseudomonas aeruginosa is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence of carbapenemase-producing P. aeruginosa has further c…
View article: Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study
Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study Open
CDI recurrence rates among cancer patients remain significant. Nonetheless, fidaxomicin and other preventive strategies are seldom used. We identified several factors that could inform the implementation of these strategies in cancer patie…
View article: Development and Validation of a Machine Learning Model for the Prediction of Bloodstream Infections in Patients with Hematological Malignancies and Febrile Neutropenia
Development and Validation of a Machine Learning Model for the Prediction of Bloodstream Infections in Patients with Hematological Malignancies and Febrile Neutropenia Open
Background/Objectives: The rise of multidrug-resistant (MDR) infections demands personalized antibiotic strategies for febrile neutropenia (FN) in hematological malignancies. This study investigates machine learning (ML) for identifying pa…
View article: Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: <scp>EPICOVIDEHA</scp>‐<scp>EPIFLUEHA</scp> Report
Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: <span>EPICOVIDEHA</span>‐<span>EPIFLUEHA</span> Report Open
Community‐acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large‐scale, real‐world data on CARV in these patients is limited.…
View article: Correction: Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients
Correction: Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients Open
[This corrects the article DOI: 10.1371/journal.pone.0240200.].
View article: Strengths and weaknesses of computerized clinical decision support systems: insights from a digital control center (C3 COVID-19) for early and personalized treatment for COVID-19
Strengths and weaknesses of computerized clinical decision support systems: insights from a digital control center (C3 COVID-19) for early and personalized treatment for COVID-19 Open
Clinical Decision Support Systems (CDSS) are computer-based tools that leverage the analysis of large volumes of health data to assist healthcare professionals in making clinical decisions, whether preventive, diagnostic, or therapeutic. T…
View article: Effectiveness, Safety, and Patterns of Real-World Isavuconazole Use in Europe (2015–2019)
Effectiveness, Safety, and Patterns of Real-World Isavuconazole Use in Europe (2015–2019) Open
This study adds to the growing body of evidence that whether used as first-line therapy or after the failure of other antifungal therapies, isavuconazole appears to have a promising clinical response and a good safety profile as an antifun…
View article: Prevalence and impact of multidrug-resistant bacteria in solid cancer patients with bloodstream infection: a 25-year trend analysis
Prevalence and impact of multidrug-resistant bacteria in solid cancer patients with bloodstream infection: a 25-year trend analysis Open
The study aimed to describe the epidemiology of multidrug-resistant (MDR) bacteria among solid cancer (SC) patients with bloodstream infections (BSIs), evaluating inappropriate empiric antibiotic treatment (IEAT) use and mortality trends o…
View article: European Study of Cerebral Aspergillosis treated with Isavuconazole (ESCAI): A study by the ESCMID Fungal Infection Study Group
European Study of Cerebral Aspergillosis treated with Isavuconazole (ESCAI): A study by the ESCMID Fungal Infection Study Group Open
Background Cerebral aspergillosis (CA) is associated with high mortality. According to the European Conference on Infections in Leukemia and the European Society of Clinical Microbiology and Infectious Diseases guidelines, the recommended …