Carola G. Vinuesa
YOU?
Author Swipe
View article: S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox
S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox Open
In systemic lupus erythematosus (SLE), autoimmunity often develops toward self nucleic acids. The nucleic acid receptors TLR7 and TLR9, which sense RNA and DNA, respectively, are critical for the generation of pathogenic autoimmune antibod…
View article: CD39 is an antibody-secreting B-cell marker that modulates germinal center and antibody responses during infection
CD39 is an antibody-secreting B-cell marker that modulates germinal center and antibody responses during infection Open
CD39 is an ectoenzyme in immune cells that regulates purinergic signaling by converting extracellular ATP into adenosine (ADO). Although first described on EBV-transformed B cells, CD39’s role in humoral immunity remains unclear. Using mur…
View article: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function Open
B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial 1–3 . The CD5 + B-1a subset expresses anti-inflammatory molecules i…
View article: Trio Whole Exome Sequencing in Chinese Childhood‐Onset Lupus Reveals Novel Candidate Genes
Trio Whole Exome Sequencing in Chinese Childhood‐Onset Lupus Reveals Novel Candidate Genes Open
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease in which rare and common gene variants contribute to pathogenesis. Severe sporadic disease in children is often explained by “de novo” variants that can be uncovered by …
View article: Whole exome sequencing in patients with childhood‐onset systemic lupus erythematosus: Results from a Croatian national study
Whole exome sequencing in patients with childhood‐onset systemic lupus erythematosus: Results from a Croatian national study Open
The purpose of this study was to identify new and low‐frequency gene variants using whole exome sequencing (WES) in patients with childhood‐onset systemic lupus erythematosus (cSLE), that may be involved in the pathogenesis of SLE. We perf…
View article: 2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism
2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism Open
Recognition of RNA fragments by Toll-like receptors (TLR) 7 and 8 is a key contributor to the initiation of a protective innate immune response against pathogens. A long-standing enigma is how degradation products of host RNAs, generated b…
View article: Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities
Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities Open
Purpose of review This review aims to provide an overview of the genes and molecular pathways involved in monogenic lupus, the implications for genome diagnosis, and the potential therapies targeting these molecular mechanisms. Recent find…
View article: Rare <i>SH2B3</i> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
Rare <i>SH2B3</i> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity Open
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear genetic component. While most SLE patients carry rare gene variants in lupus risk genes, little is known about their contribution to disease pathogenesis…
View article: The transcription factor ZEB2 drives the formation of age-associated B cells
The transcription factor ZEB2 drives the formation of age-associated B cells Open
Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding hom…
View article: The transcription factors TCF1 and LEF1 drive B-1a cell development, self-renewal, and regulatory function.
The transcription factors TCF1 and LEF1 drive B-1a cell development, self-renewal, and regulatory function. Open
B-1 cells are abundant in peritoneal and pleural cavities and produce natural and microbial-induced IgM and IgA1–4.CD5+ B-1 cells known as “B-1a” represent the largest source of B cell-derived IL-105,6, an important regulator of inflammati…
View article: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency Open
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable …
View article: IKK2 controls the inflammatory potential of tissue-resident regulatory T cells
IKK2 controls the inflammatory potential of tissue-resident regulatory T cells Open
Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3 + regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or …
View article: Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection Open
TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-i…
View article: Ataxia telangiectasia and juvenile idiopathic arthritis: A coincidence or a relationship?
Ataxia telangiectasia and juvenile idiopathic arthritis: A coincidence or a relationship? Open
The data that support the findings of this study are available upon request from the corresponding author, MJ. These data are not publicly available due to their containing information that could compromise the privacy of research particip…
View article: The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus
The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus Open
The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) is complex and not fully understood. It involves three key factors: genetic risk factors, epigenetic mechanisms, and environmental triggers. Genetic factors play a sig…
View article: Rare<i>SH2B3</i>coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity
Rare<i>SH2B3</i>coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity Open
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, with a clear genetic component. While most SLE patients carry rare gene variants in lupus risk genes, little is known about their contribution to disease pathogenesi…
View article: Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis
Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis Open
Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement. Kidney involvement, termed lupus nephritis, has major impact on life expectan…
View article: A common human<i>MLKL</i>polymorphism confers resistance to negative regulation by phosphorylation
A common human<i>MLKL</i>polymorphism confers resistance to negative regulation by phosphorylation Open
Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL , the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. We show that this substitution confers a gain in …
View article: TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses
TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses Open
Follicular T cells including T follicular helper (T FH ) and T follicular regulatory (T FR ) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC). Follicular T cell mig…
View article: Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response Open
During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation …