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View article: Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease
Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease Open
The link between subthalamic nucleus deep brain stimulation (STN‐DBS) and apathy in patients with Parkinson's disease (PD) remains a controversial topic. The literature is mixed and the most supported explanation is the reduction of dopami…
View article: Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks
Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks Open
Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested to be triggered or aggravated by treatments with dopamine D…
View article: Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use Open
The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of motivational processes, dopamine (DA), is suspected to play an important role in this pathol…
View article: Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use Open
The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of motivational processes dopamine (DA) is suspected to play an important role in this patholog…
View article: Early diagnosis of Parkinson’s disease: A cross-species biomarker
Early diagnosis of Parkinson’s disease: A cross-species biomarker Open
Background Care management of Parkinson’s disease (PD) patients currently remains symptomatic, especially because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Detecting PD earlier therefore represent…
View article: Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats
Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience. However, the first used ligands exhibited dose-dependent selectivity for their molecular target, leading to …
View article: Unilateral and Bilateral Subthalamic stimulation differently promote apathy: a translational approach
Unilateral and Bilateral Subthalamic stimulation differently promote apathy: a translational approach Open
Apathy, depression, and anxiety represent the main neuropsychiatric symptoms of Parkinson’s disease (PD). How subthalamic nucleus deep brain stimulation (STN-DBS) influences these symptoms, especially apathy, is a controversial topic. The …
View article: Reply to: Letter to the Editor by Martínez‐Fernández
Reply to: Letter to the Editor by Martínez‐Fernández Open
International audience
View article: Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats
Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats Open
Although Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience, the first ligands used were not as selective as expected. Compound 21 (C21) was recently proposed a…
View article: Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease
Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease Open
Background Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation. Indeed, despite its effectiveness for a…
View article: Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis
Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis Open
Brain metal homeostasis is altered in neurodegenerative diseases and the concentration, the localization and/or the chemical speciation of the elements can be modified compared to healthy individuals. These changes are often specific to th…
View article: DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands
DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands Open
International audience
Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers Open
microRNAs are small non-coding RNAs gaining interest for their potential roles as reliable biomarkers for the diagnosis and therapeutics of numerous pathologies, ranging from cancer to neurodegenerative or psychiatric disorders. Indeed, mi…
View article: Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson’s Disease
Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson’s Disease Open
Impulse control disorders (ICDs) are frequent behavioral complications of dopaminergic (DA) replacement therapies (DRTs) in Parkinson's disease (PD). Impulsive choice, which refers to an inability to tolerate delays to reinforcement, has b…
View article: Organization of the Anterior Limb of the Internal Capsule in the Rat
Organization of the Anterior Limb of the Internal Capsule in the Rat Open
Dysfunction of the orbitofrontal (OFC) and anterior cingulate (ACC) cortices has been linked with several psychiatric disorders, including obsessive-compulsive disorder, major depressive disorder, posttraumatic stress disorder, and addicti…