Carolin Lackner
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View article: Preliminary qualification of a machine learning-based assessment of the tumor immune infiltrate as a predictor of outcome in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab
Preliminary qualification of a machine learning-based assessment of the tumor immune infiltrate as a predictor of outcome in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab Open
Spontaneously immunogenic hepatocellular carcinoma (HCC), identified by a dense immune cell infiltrate (ICI), responds better to immunotherapy, although no validated biomarker exists to identify these cases. We used machine learning (ML) t…
View article: Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models.
Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models. Open
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine-monophosphate (cGMP) pathway is impaired in liver fibrosis. We investigated expression patterns of NO-sGC-cGMP components via RT-qPCR in various rat models of liver fib…
View article: Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation
Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation Open
Measurement of the hepatic venous pressure gradient (HVPG) and transjugular liver biopsy have emerged as important tools in clinical hepatology. Measurement of HVPG is considered the gold standard for detecting clinically significant porta…
View article: Inflammation remains a dynamic component of portal hypertension in regressive alcohol‐related cirrhosis
Inflammation remains a dynamic component of portal hypertension in regressive alcohol‐related cirrhosis Open
Background Portal hypertension (PH) resulting from static and dynamic intrahepatic changes drives liver‐related complications even after removing the underlying aetiological factor. Objective We investigated the impact of inflammation on t…
View article: Making Sense of ‘Porto‐Sinusoidal Vascular Disorder’: What Does It Mean for the Pathologist and the Patient?
Making Sense of ‘Porto‐Sinusoidal Vascular Disorder’: What Does It Mean for the Pathologist and the Patient? Open
View article: Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease
Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease Open
View article: Steatotic liver disease associated with 2,4-dienoyl-CoA reductase 1 deficiency
Steatotic liver disease associated with 2,4-dienoyl-CoA reductase 1 deficiency Open
View article: Severe acute liver disease in adults: Contemporary role of histopathology
Severe acute liver disease in adults: Contemporary role of histopathology Open
Liver biopsies have consistently contributed to our understanding of the pathogenesis and aetiologies of acute liver disease. As other diagnostic modalities have been developed and refined, the role of biopsy in the management of patients …
View article: Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology
Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology Open
Alcohol-associated steatohepatitis (ASH) is diagnosed on liver histology but liver biopsy is not always feasible. Non-invasive diagnosis based on clinical findings has been proposed using the National Institute on Alcohol Abuse and Alcohol…
View article: Bile acids mediate fructose-associated liver tumour growth in mice
Bile acids mediate fructose-associated liver tumour growth in mice Open
High fructose diets are associated with an increased risk of liver cancer. Previous studies in mice suggest increased lipogenesis is a key mechanism linking high fructose diets to liver tumour growth. However, these studies administered fr…
View article: Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease
Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease Open
Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite the global burden of ALD, there is a lack of effective treatments, and mortality i…
View article: Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 146K, Additional clinical data and detailed Material & Methods section
View article: Supplementary Figure 4 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 4 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 1362K, Evaluation of available material from patient #38. (a-b) Array CGH profiles of the primary tumor (a) and liver metastasis (b).
View article: Supplementary Figure 5 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 5 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 346K, Analysis of CTC03 of patient #22: The array-CGH ratio profile demonstrates losses on chromosomes 3, 4, 5, 8p, and 18 and gains on chromosomes 7p, 17q, and 20.
View article: Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 1233K, Additional CTCs from patient #26. Individual CTC-integer number profiles from CTCs 05 (a), 24 (b), 25 (c), 28 (d).
View article: Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 146K, Additional clinical data and detailed Material & Methods section
View article: Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 95K, List of 68 genes, which, according to the COSMIC database, are frequently mutated in colorectal carcinoma (CRC) and analyzed in our study.
View article: Supplementary Figure 6 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 6 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 188K, Sequencing of UCR41 and flanking regions: UCR41 is a 217-bp-long ultra-conserved region depicted in dark green. The gray bar indicates the extremely conserved sequence. The region is flanked by two SNPs that are frequent i…
View article: Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 1303K, Evaluation of available material from patient #9. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (peritoneal carcinomatosis) (b). Regarding the color bar codes please see legend to Supp. Fig. 2.
View article: Supplementary Figure 8 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 8 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 3383K, Calculation of different integer copy number profiles for CTC03 from patient #6 assuming diploidy (a), triploidy (b), or tetraploidy (c) and the respective array CGH profile (d).
View article: Supplementary Table 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Table 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 98K, Summary of clinical characteristics of the 6 colorectal carcinoma (CRC) patients.
View article: Supplementary Figure 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 940K, Evaluation of available material from patient #6. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (b). The multicolor bar codes at the top or bottom of the ratio profiles illustrate the results obtained du…
View article: Supplementary Figure 7 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 7 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 868K, Ratio bin distributions for CTC12 (a) and CTC03 (b) from patient #6. The large bin 13 peak indicates the frequency of oligonucleotides with balanced ratio values. The bins to the right of 13 represent the bins for oligonuc…
View article: Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 1233K, Additional CTCs from patient #26. Individual CTC-integer number profiles from CTCs 05 (a), 24 (b), 25 (c), 28 (d).
View article: Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Table 2 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 95K, List of 68 genes, which, according to the COSMIC database, are frequently mutated in colorectal carcinoma (CRC) and analyzed in our study.
View article: Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 231K, Evaluation of available material from patient #6. (c) Integer copy number profiles of CTC14.
View article: Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 231K, Evaluation of available material from patient #6. (c) Integer copy number profiles of CTC14.
View article: Supplementary Table 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Table 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 98K, Summary of clinical characteristics of the 6 colorectal carcinoma (CRC) patients.
View article: Data from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Data from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
Circulating tumor cells (CTC) released into blood from primary cancers and metastases reflect the current status of tumor genotypes, which are prone to changes. Here, we conducted the first comprehensive genomic profiling of CTCs using arr…
View article: Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing Open
PDF file - 1303K, Evaluation of available material from patient #9. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (peritoneal carcinomatosis) (b). Regarding the color bar codes please see legend to Supp. Fig. 2.