Carolin Mogler
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View article: Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome Open
Recent studies have shown that pulmonary neuroendocrine tumor (NET) subgroups, defined by the transcription factors OTP and ASCL1, correlate with age, sex, and tumor location. Their relationships with histology and hormone production, howe…
View article: Preclinical Evaluation of Stable Integrin αvβ3-Specific [198Au]Gold Nanoparticles for Tumor Therapy
Preclinical Evaluation of Stable Integrin αvβ3-Specific [198Au]Gold Nanoparticles for Tumor Therapy Open
Objectives: This paper reports the preclinical evaluation of stable tumor-specific gold nanoparticles (AuNPs) activated by neutron irradiation as a therapeutic option for the treatment of cancers characterized by high tumor angiogenesis. M…
View article: From pixels to pathology: Restoration diffusion for diagnostic-consistent virtual IHC
From pixels to pathology: Restoration diffusion for diagnostic-consistent virtual IHC Open
Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression…
View article: Lenvatinib after progression on pemigatinib and futibatinib in FGFR2 fusion-positive biliary tract cancer with an acquired kinase point mutation
Lenvatinib after progression on pemigatinib and futibatinib in FGFR2 fusion-positive biliary tract cancer with an acquired kinase point mutation Open
Biliary tract cancers (BTC) represent a heterogeneous group of malignancies with a poor prognosis and rising incidence. Oncogenic FGFR2 fusions are one of several actionable molecular alterations. In this context, selective FGFR tyrosine k…
View article: Detailed Characterization and Comparison of Mouse Models for Cholangiocarcinoma
Detailed Characterization and Comparison of Mouse Models for Cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is an aggressive malignancy that originates in the bile ducts and is characterized by late-stage diagnosis and limited treatment options. CCA accounts for approximately 10% to 15% of primary liver tumors. Recent ge…
View article: Gefäßtumoren der Leber
Gefäßtumoren der Leber Open
View article: MVA-HBVac—A novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination
MVA-HBVac—A novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination Open
View article: Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD Open
In this study, we identify a novel immunometabolic axis in which polyunsaturated fatty acids, accumulating in liver tissue in MASLD (metabolic dysfunction-associated steatotic liver disease), drive MAIT (mucosal-associated invariant T) cel…
View article: Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease
Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease Open
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identified a replication enhancing domain (ReED) in nonstructural protein 5A conferring high…
View article: Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC
Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC Open
Patients with head and neck squamous cell carcinoma (HNSCC) suffer from severe morbidity and mortality. Immunotherapy represents a novel promising treatment option. Therefore, a better understanding of the immune niche is needed. This stud…
View article: Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma
Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma Open
View article: Does Size Outweigh Number in Predicting Survival After Pulmonary Metastasectomy for Soft Tissue Sarcoma? Insights from a Retrospective Multicenter Study
Does Size Outweigh Number in Predicting Survival After Pulmonary Metastasectomy for Soft Tissue Sarcoma? Insights from a Retrospective Multicenter Study Open
Background Pulmonary metastasectomy (PM) is the most frequently performed local ablative therapy for leiomyosarcoma (LMS), synovial sarcoma (SyS), and undifferentiated pleomorphic sarcoma (UPS). This study aimed to assess surgical feasibil…
View article: Malignant Chondroblastoma: An Epigenetically Distinct Subtype of Chondroblastoma With a Predilection for the Skeletally Mature
Malignant Chondroblastoma: An Epigenetically Distinct Subtype of Chondroblastoma With a Predilection for the Skeletally Mature Open
Malignant chondroblastoma is a recently described variant of chondroblastoma showing a distinct age/site distribution and morphology along with the typical H3-3B p.K36M mutation. We sought to further compare conventional and malignant chon…
View article: Is Ectopic Cushing Syndrome Commonly Associated with Small Cell Lung Cancer (SCLC)? Critical Review of the Literature and ACTH Expression in Resected SCLC
Is Ectopic Cushing Syndrome Commonly Associated with Small Cell Lung Cancer (SCLC)? Critical Review of the Literature and ACTH Expression in Resected SCLC Open
View article: Morphological, immunohistochemical and molecular analysis of follicular dendritic cell sarcomas: <scp>L1CAM</scp> as a new diagnostic marker
Morphological, immunohistochemical and molecular analysis of follicular dendritic cell sarcomas: <span>L1CAM</span> as a new diagnostic marker Open
Aims Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm exhibiting morphological and immunophenotypical features of follicular dendritic cells. Given its rarity and broad morphological spectrum, diagnosis can be challenging. Knowl…
View article: Immunohistochemical Profiling of IDO1 and IL4I1 in Head and Neck Squamous Cell Carcinoma: Interplay for Metabolic Reprogramming?
Immunohistochemical Profiling of IDO1 and IL4I1 in Head and Neck Squamous Cell Carcinoma: Interplay for Metabolic Reprogramming? Open
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous and malignant disease with a limited number of biomarkers and insufficient targeted therapies. The current therapeutic landscape is challenged by low response rates, undersco…
View article: Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 Open
Background A rise in paediatric cases of acute hepatitis of unknown origin (AHUO) was observed in 2022, some requiring liver transplantation. A link to adeno-associated virus 2 infection and CD4 + T-cell mediated disease was reported in co…
View article: Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the PI3K/AKT pathway alterations
Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the PI3K/AKT pathway alterations Open
Background Hidradenoma papilliferum (HP) is a rare, benign epithelial tumour arising from the anogenital mammary-like glands, that occurs almost exclusively in the anogenital region of middle-aged women. To-date, genetic characterisation o…
View article: A deep learning model for classification of chondroid tumors on CT images
A deep learning model for classification of chondroid tumors on CT images Open
View article: p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells Open
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Here we report a mechanism directly linking genomic instability and inflammation in senescent cells through a mitoc…
View article: An equivalency and efficiency study for one year digital pathology for clinical routine diagnostics in an accredited tertiary academic center
An equivalency and efficiency study for one year digital pathology for clinical routine diagnostics in an accredited tertiary academic center Open
Digital pathology is revolutionizing clinical diagnostics by offering enhanced efficiency, accuracy, and accessibility of pathological examinations. This study explores the implementation and validation of digital pathology in a large tert…
View article: The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms
The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms Open
The labyrinthian fetoplacental capillary network is vital for proper nourishment of the developing embryo. Dysfunction of the maternal-fetal circulation is a primary cause of placental insufficiency. Here, we show that the spatial zonation…
View article: SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death
SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death Open
SARS‐CoV‐2 infection is accompanied by elevated liver enzymes, and patients with pre‐existing liver conditions experience more severe disease. While it was known that SARS‐CoV‐2 infects human hepatocytes, our study determines the mechanism…
View article: Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas Open
Background We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). Methods We analyzed digitized H&E-stained slides from a multicenter cohort of five large univ…
View article: Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study
Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study Open
Proteome profiling of formalin-fixed paraffin-embedded (FFPE) specimens has gained traction for the analysis of cancer tissue for the discovery of molecular biomarkers. However, reports so far focused on single cancer entities, comprised r…
View article: Pancreatic Cancer: Current Concepts, Trends, and Future Directions
Pancreatic Cancer: Current Concepts, Trends, and Future Directions Open
Pancreatic ductal adenocarcinoma (PC) ranks among the deadliest cancers, with a less than 15% 5-year survival rate. Epidemiological studies project that it will become the second leading cause of cancer-associated mortalities in the follow…
View article: Pediatric Bone Tumors: Location and Age Distribution of 420 Cases
Pediatric Bone Tumors: Location and Age Distribution of 420 Cases Open
Background/Objectives: One of the most important diagnostic tools in bone tumors is X-rays. Preliminary and, in the case of some benign lesions, definitive diagnoses are formed using this basic tool. Part of the decision making in this sta…
View article: Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation
Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation Open
View article: Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma
Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma Open
Wnt signalling must be ‘just right’ to promote tumour growth. Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland are rare tumours that can be difficult to distinguish from each other and other salivary glan…
View article: Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells
Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells Open
Background The primary goal of surgery in HNSCC is the complete resection of tumor cells with maximum preservation of normal tissue. The membrane Hsp70-targeting fluorescence labelled peptide TPP-IRDye800 represents a promising tool for re…