Carolin Ploeger
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View article: 155eP Microcosting analysis of combined whole genome sequencing and whole transcriptome sequencing in cancer diagnostics
155eP Microcosting analysis of combined whole genome sequencing and whole transcriptome sequencing in cancer diagnostics Open
View article: Comprehensive genomic profiling requires a blended ecosystem of learning healthcare and clinical trials
Comprehensive genomic profiling requires a blended ecosystem of learning healthcare and clinical trials Open
View article: Regulation (EU) 2017/746 (IVDR): practical implementation of annex I in pathology
Regulation (EU) 2017/746 (IVDR): practical implementation of annex I in pathology Open
View article: Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients
Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients Open
A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmen…
View article: Die Verordnung (EU) 2017/746 (IVDR) in der Praxis: Umsetzung von Anhang I in der Pathologie
Die Verordnung (EU) 2017/746 (IVDR) in der Praxis: Umsetzung von Anhang I in der Pathologie Open
View article: Precision cancer medicine: Concepts, current practice, and future developments
Precision cancer medicine: Concepts, current practice, and future developments Open
Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological…
View article: Structure and content of the EU-IVDR
Structure and content of the EU-IVDR Open
View article: STAT1 and STAT3 Exhibit a Crosstalk and Are Associated with Increased Inflammation in Hepatocellular Carcinoma
STAT1 and STAT3 Exhibit a Crosstalk and Are Associated with Increased Inflammation in Hepatocellular Carcinoma Open
Liver cancers, which are mostly hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are very aggressive tumors with poor prognosis. Therapeutic options with curative intent are largely limited to surgery and available systemic the…
View article: Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine
Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine Open
Modern concepts in precision cancer medicine are based on increasingly complex genomic analyses and require standardized criteria for the functional evaluation and reporting of detected genomic alterations in order to assess their clinical…
View article: Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria
Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria Open
View article: <scp>NTRK</scp>testing: First results of the<scp>QuiP‐EQA</scp>scheme and a comprehensive map of<scp><i>NTRK</i></scp>fusion variants and their diagnostic coverage by targeted<scp>RNA</scp>‐based<scp>NGS</scp>assays
<span>NTRK</span>testing: First results of the<span>QuiP‐EQA</span>scheme and a comprehensive map of<span><i>NTRK</i></span>fusion variants and their diagnostic coverage by targeted<span>RNA</span>‐based<span>NGS</span>assays Open
Gene fusions involving the three neurotrophic tyrosine receptor kinase genes NTRK1 , NTRK2 , or NTRK3 were identified as oncogenic drivers in many cancer types. Two small molecule inhibitors have been tested in clinical trials recently and…
View article: NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis
NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis Open
View article: Spatial and Temporal Heterogeneity of Panel-Based Tumor Mutational Burden in Pulmonary Adenocarcinoma: Separating Biology From Technical Artifacts
Spatial and Temporal Heterogeneity of Panel-Based Tumor Mutational Burden in Pulmonary Adenocarcinoma: Separating Biology From Technical Artifacts Open
View article: Variant classification in precision oncology
Variant classification in precision oncology Open
Next‐generation sequencing has become a cornerstone of therapy guidance in cancer precision medicine and an indispensable research tool in translational oncology. Its rapidly increasing use during the last decade has expanded the options f…
View article: Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin‐6 signaling in hepatocellular carcinoma
Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin‐6 signaling in hepatocellular carcinoma Open
Several chronic inflammatory liver diseases, e.g., chronic hepatitis B or C viral infection and steatohepatitis, have been shown to predispose to the development of hepatocellular carcinoma (HCC). In patients with chronic liver disease, in…