Cristiane S. Rocha
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View article: Effects of Polydatin on Pentylenetetrazol-Induced Seizures in Zebrafish Larvae
Effects of Polydatin on Pentylenetetrazol-Induced Seizures in Zebrafish Larvae Open
Background/Objectives: Epilepsy is a common neurological condition characterized by the occurrence of a seizure. It affects around 50 million individuals worldwide, and despite the large quantity of anti-seizure medications available, 30% …
View article: Correction: Impact of genetic background as a risk factor for atherosclerotic cardiovascular disease: A protocol for a nationwide genetic case-control (CV-GENES) study in Brazil
Correction: Impact of genetic background as a risk factor for atherosclerotic cardiovascular disease: A protocol for a nationwide genetic case-control (CV-GENES) study in Brazil Open
[This corrects the article DOI: 10.1371/journal.pone.0289439.].
View article: Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease
Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease Open
Parkinson’s disease is the second most common neurodegenerative disease. Despite this, there are no robust biomarkers to predict progression, and understanding of disease mechanisms is limited. We used the Subtype and Stage Inference algor…
View article: TRANSTORNO DO ESPECTRO AUTISTA E VARIANTE NO GENE TCF20: UM RELATO DE CASO
TRANSTORNO DO ESPECTRO AUTISTA E VARIANTE NO GENE TCF20: UM RELATO DE CASO Open
O estudo aborda a relação entre o gene TCF20 e o Transtorno do Espectro Autista (TEA), destacando a importância da investigação genética no diagnóstico e manejo da condição. Objetivo: relatar o caso de uma paciente de 22 anos com TEA e def…
View article: A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease
A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease Open
View article: Impact of genetic background as a risk factor for atherosclerotic cardiovascular disease: A protocol for a nationwide genetic case-control (CV-GENES) study in Brazil
Impact of genetic background as a risk factor for atherosclerotic cardiovascular disease: A protocol for a nationwide genetic case-control (CV-GENES) study in Brazil Open
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based st…
View article: Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19
Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 Open
Although some studies have shown neuroimaging and neuropsychological alterations in post-COVID-19 patients, fewer combined neuroimaging and neuropsychology evaluations of individuals who presented a mild acute infection. Here we investigat…
View article: DESENVOLVIMENTO DE TESTE DIAGNÓSTICO PARA LEUCEMIA LINFOBLÁSTICA AGUDA POR SEQUENCIAMENTO DE NOVA GERAÇÃO
DESENVOLVIMENTO DE TESTE DIAGNÓSTICO PARA LEUCEMIA LINFOBLÁSTICA AGUDA POR SEQUENCIAMENTO DE NOVA GERAÇÃO Open
Objetivos: Desenvolver e validar um teste genético para análise de mutações somáticas relacionadas a leucemia linfoblástica aguda (LLA) e assim dispor de uma abordagem molecular de investigação genética por meio de sequenciamento de nova g…
View article: Impact of Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease: A Protocol for a Nationwide Genetic Case-Control (CV-GENES) study in Brazil
Impact of Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease: A Protocol for a Nationwide Genetic Case-Control (CV-GENES) study in Brazil Open
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based st…
View article: Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19
Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 Open
Background: Little is known about the underpinning mechanisms of neurological dysfunction in post-COVID syndrome. Methods: We conducted a cross-sectional study of 87 consecutive subjects after a mild infection, with a median of 54 days aft…
View article: Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy
Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy Open
Most patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) have hippocampal sclerosis on the postoperative histopathological examination. Although most patients with MTLE do not refer to a family history of the disease, fami…
View article: Benchmarking the proteomic profile of animal models of mesial temporal epilepsy
Benchmarking the proteomic profile of animal models of mesial temporal epilepsy Open
Objectives We compared the proteomic signatures of the hippocampal lesion induced in three different animal models of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS): the systemic pilocarpine model (PILO), the intracereb…
View article: Clinical-epidemiological profile of chemical burns in a Burn Therapy Unit (BTU) in Brazil
Clinical-epidemiological profile of chemical burns in a Burn Therapy Unit (BTU) in Brazil Open
Introduction: Chemicals have a relatively low prevalence among the causes of burns. However, they are important because most accidents occur in the scope of work and in an economically active population. The objective is to perform an anal…
View article: Análise clínico-epidemiológica de pacientes HIV positivos internados em uma Unidade de Terapia de Queimados
Análise clínico-epidemiológica de pacientes HIV positivos internados em uma Unidade de Terapia de Queimados Open
RESUMO Introdução: A infecção pelo HIV e as queimaduras são um problema comum de saúde pública, principalmente em países de baixa e média renda. Há uma escassez na literatura sobre a epidemiologia de pacientes HIV positivos hospitalizados …
View article: Perfil clínico-epidemiológico de queimaduras químicas em uma Unidade de Terapia de Queimados no Brasil
Perfil clínico-epidemiológico de queimaduras químicas em uma Unidade de Terapia de Queimados no Brasil Open
Clinical-epidemiological profile of chemical burns in a Burn Therapy Unit (BTU) in BrazilIntrodução: Substâncias químicas apresentam uma prevalência relativamente baixa dentre as causas de queimaduras.Porém, têm importância, pois a maioria…
View article: Clinical-epidemiological analysis of HIV positive patients hospitalized in a Burn Therapy Unit
Clinical-epidemiological analysis of HIV positive patients hospitalized in a Burn Therapy Unit Open
A Revista Brasileira de Cirurgia Plástica é o órgão oficial de divulgação da Sociedade Brasileira de Cirurgia Plástica (SBCP), tem como objetivo registrar a produção científica em Cirurgia Plástica, fomentar o estudo, aperfeiçoamento e atu…
View article: Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model
Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model Open
Focal cortical dysplasia is a highly epileptogenic cortical malformation with few treatment options. Here, we generated human cortical organoids from patients with focal cortical dysplasia type II. Using this human model, we mimicked some …
View article: Mild COVID-19 infection associates with persistent neurological symptoms
Mild COVID-19 infection associates with persistent neurological symptoms Open
View article: International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease Open
Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease st…
View article: Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial
Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial Open
Objective Focal cortical dysplasia (FCD) is a major cause of difficult‐to‐treat epilepsy in children and young adults, and the diagnosis is currently based on microscopic review of surgical brain tissue using the International League Again…
View article: Genetic variability in COVID-19-related genes in the Brazilian population
Genetic variability in COVID-19-related genes in the Brazilian population Open
View article: Exploring a Region on Chromosome 8p23.1 Displaying Positive Selection Signals in Brazilian Admixed Populations: Additional Insights Into Predisposition to Obesity and Related Disorders
Exploring a Region on Chromosome 8p23.1 Displaying Positive Selection Signals in Brazilian Admixed Populations: Additional Insights Into Predisposition to Obesity and Related Disorders Open
We recently reported a deviation of local ancestry on the chromosome (ch) 8p23.1, which led to positive selection signals in a Brazilian population sample. The deviation suggested that the genetic variability of candidate genes located on …
View article: Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19
Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 Open
Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations in patients who did not requi…
View article: miRNA transcriptome from zebrafish PTZ model
miRNA transcriptome from zebrafish PTZ model Open
MicroRNA transcriptome data from wild-type zebrafish (Danio rerio) larvae after chemical-induced seizure using pentylenetetrazole (PTZ). Three different conditions were investigated: (i) status epilepticus, SE (3h of PTZ-induced seizure); …
View article: The impact of post-alignment processing procedures on whole-exome sequencing data
The impact of post-alignment processing procedures on whole-exome sequencing data Open
The use of post-alignment procedures has been suggested to prevent the identification of false-positives in massive DNA sequencing data. Insertions and deletions are most likely to be misinterpreted by variant calling algorithms. Using kno…
View article: mRNA transcriptome from zebrafish pentylenetetrazole (PTZ) model
mRNA transcriptome from zebrafish pentylenetetrazole (PTZ) model Open
Messenger RNA transcriptome data from wild-type zebrafish (Danio rerio) larvae after chemical-induced seizure using pentylenetetrazole (PTZ).. Three different conditions were investigated: (i) status epilepticus, SE (3h of PTZ-induced seiz…
View article: Genetic variability in COVID-19-related genes in the Brazilian population
Genetic variability in COVID-19-related genes in the Brazilian population Open
SARS-CoV-2 employs the angiotensin-converting enzyme 2 (ACE2) receptor and the transmembrane serine protease (TMPRSS2) to infect human lung cells. Previous studies have suggested that different host genetic backgrounds in ACE2 and TMPRSS2 …
View article: The Brazilian Initiative on Precision Medicine (BIPMed): fostering genomic data-sharing of underrepresented populations
The Brazilian Initiative on Precision Medicine (BIPMed): fostering genomic data-sharing of underrepresented populations Open
View article: Using association rule mining to jointly detect clinical features and differentially expressed genes related to chronic inflammatory diseases
Using association rule mining to jointly detect clinical features and differentially expressed genes related to chronic inflammatory diseases Open
ARM was a powerful data analysis technique to identify multivariate patterns involving clinical and molecular profiles of patients affected by specific pathological panels. ARM proved to be an effective mining approach to analyze gene expr…
View article: White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study
White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study Open
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in commo…