Carolina E. Echeverría
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View article: Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis
Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis Open
View article: The human microbiome in clinical translation: from bench to bedside
The human microbiome in clinical translation: from bench to bedside Open
The human microbiome, once regarded as a passive passenger, is now recognized as a dynamic and essential determinant of human physiology, shaping immunity, metabolism, neurodevelopment, and therapeutic responsiveness across the lifespan. A…
View article: Reprogramming cancer immunity with next-generation combination therapies
Reprogramming cancer immunity with next-generation combination therapies Open
Cancer immunotherapy has fundamentally reshaped oncology by harnessing the immune system to eliminate malignant cells. Immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1 have achieved durable remissions in select cancers, yet mos…
View article: Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose Stimulation
Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose Stimulation Open
Background Dietary sugars, particularly fructose, are increasingly implicated in cancer progression through their impact on tumor metabolism. However, the specific metabolic adaptations driven by fructose in prostate cancer (PCa) remain un…
View article: Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells Open
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichannels, HC). Cxs were initially …
View article: Biological role of fructose in the male reproductive system: Potential implications for prostate cancer
Biological role of fructose in the male reproductive system: Potential implications for prostate cancer Open
Background Over the last 20 years, fructose has gradually emerged as a potential metabolic substrate capable of promoting the growth and progression of various cancers, including prostate cancer (PCa). The biological and molecular mechanis…
View article: Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth Open
Glut(s) expression PC-3 cell line-derived xenograft model.
View article: Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth Open
Gene Set Enrichment Analysis (GSEA) from RNA sequencing data of PC3 cells stimulated with fructose or glucose.
View article: Table S1 from Dietary Fructose Promotes Prostate Cancer Growth
Table S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Biological/clinical parameters (patient age, PSA levels, Gleason score) and glucose and fructose levels in benign and PCa patients.
View article: Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Downregulation of Glut-5 expression in PC-3 cells using the siRNA methodology.
View article: Table S1 from Dietary Fructose Promotes Prostate Cancer Growth
Table S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Biological/clinical parameters (patient age, PSA levels, Gleason score) and glucose and fructose levels in benign and PCa patients.
View article: Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth Open
Glut(s) expression PC-3 cell line-derived xenograft model.
View article: Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Downregulation of Glut-5 expression in PC-3 cells using the siRNA methodology.
View article: Data from Dietary Fructose Promotes Prostate Cancer Growth
Data from Dietary Fructose Promotes Prostate Cancer Growth Open
Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical a…
View article: Data from Dietary Fructose Promotes Prostate Cancer Growth
Data from Dietary Fructose Promotes Prostate Cancer Growth Open
Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical a…
View article: Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth Open
Gene Set Enrichment Analysis (GSEA) from RNA sequencing data of PC3 cells stimulated with fructose or glucose.
View article: The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells
The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells Open
The survival of patients with solid tumors, such as prostate cancer (PCa), has been limited and fleeting with anti-angiogenic therapies. It was previously thought that the mechanism by which the vasculature regulates tumor growth was drive…
View article: Interacción de factores ambientales y genéticos asociados el desarrollo del cáncer de ovario
Interacción de factores ambientales y genéticos asociados el desarrollo del cáncer de ovario Open
El cáncer de ovario es la neoplasia maligna ginecológica más letal debido a su asintomatología y etapa avanzada de diagnóstico. La tasa de incidencia a nivel mundial es de 6,3 por cada 100.000 mujeres, presentando las tasas más altas en zo…