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View article: In vitro evaluation of Ibrexafungerp against clinical and environmental isolates of cryptococcus neoformans and cryptococcus gattii
In vitro evaluation of Ibrexafungerp against clinical and environmental isolates of cryptococcus neoformans and cryptococcus gattii Open
View article: Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity
Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity Open
The number of fungal infections is steadily increasing, with considerable morbidity and mortality. Additionally, antifungal resistance is a growing concern, highlighting the need to develop new treatment options. One alternative is the use…
View article: Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans Open
View article: Broad Antifungal Spectrum of the Pore-Forming Peptide C14R Against Cryptococcus and Candida Species from the WHO Fungal Priority Pathogens List
Broad Antifungal Spectrum of the Pore-Forming Peptide C14R Against Cryptococcus and Candida Species from the WHO Fungal Priority Pathogens List Open
The World Health Organization (WHO) prioritized 19 fungal species based on the significant impact of these pathogens on human health, including the emergence of antifungal resistance, which highlights the necessity of finding new antifunga…
View article: Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options Open
The rising prevalence of fungal infections, especially those caused by Candida species, presents a major risk to global health. With approximately 1.5 million deaths annually, the urgency for effective treatment options has never been grea…
View article: Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma auris
Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma auris Open
Biofilms are the predominant lifeforms of microorganisms, contributing to over 80% of infections, including those caused by Candida species like C. albicans, C. parapsilosis and Candidozyma auris. These species form biofilms on medical dev…
View article: Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of <em>Candida albicans</em>, <em>C. auris</em> and <em>C. parapsilosis</em>
Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of <em>Candida albicans</em>, <em>C. auris</em> and <em>C. parapsilosis</em> Open
Biofilms are the predominant lifestyle for microorganisms, contributing to over 80% of infections, including those caused by Candida species like C. albicans, C. auris, and C. parapsilosis. These species form biofilms on medical devices, m…
View article: Occurrence of pathogenic yeast species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates
Occurrence of pathogenic yeast species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates Open
Yeasts are widely known for their application in food production, but also because of their clinical significance. As human pathogens, several species of yeasts, mainly of the genus Candida, are responsible for a great number of life-threa…
View article: Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans Open
Candida albicans infections are a global health thread and challenge healthcare environments due to acquired resistances against prominent antifungals like amphotericin B and fluconazole, which additionally have severe adverse effects. The…
View article: Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans
Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans Open
Background Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii . Neutralizing autoantibodies (auto-Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults w…
View article: Occurrence of pathogenic Candida species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates
Occurrence of pathogenic Candida species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates Open
Yeasts are widely known for their application in food production, but also because of their clinical significance. As human pathogens, several species of yeasts, mainly of the genus Candida , are responsible for a great number of life-thr…
View article: Fatal co-infection by multiple pathogens in an indigenous woman with autoimmune hemolytic anemia and tuberculosis: a case report
Fatal co-infection by multiple pathogens in an indigenous woman with autoimmune hemolytic anemia and tuberculosis: a case report Open
View article: Candida Non-albicans and Non-auris Causing Invasive Candidiasis in a Fourth-Level Hospital in Colombia: Epidemiology, Antifungal Susceptibility, and Genetic Diversity
Candida Non-albicans and Non-auris Causing Invasive Candidiasis in a Fourth-Level Hospital in Colombia: Epidemiology, Antifungal Susceptibility, and Genetic Diversity Open
Increasingly common and associated with healthcare settings, Candida infections are very important, since some species of this genus can develop antifungal resistance. We contribute data on the epidemiology, antifungal susceptibility, and …
View article: Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris Open
Introduction Invasive candidiasis is a global public health problem as it poses a significant threat in hospital-settings. The aim of this study was to evaluate C14R, an analog derived from peptide BP100, as a potential antimicrobial pepti…
View article: Autoantibodies neutralizing GM-CSF in HIV-negative Colombian patients infected with Cryptococcus gattii and C. neoformans
Autoantibodies neutralizing GM-CSF in HIV-negative Colombian patients infected with Cryptococcus gattii and C. neoformans Open
Background: Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii. Autoantibodies (auto-Abs) neutralizing granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryp…
View article: Occurrence of pathogenic yeast species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates
Occurrence of pathogenic yeast species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates Open
Yeasts are widely known for their application in food production, but also because of their clinical significance. As human pathogens, several species of yeasts, mainly of the genus Candida and other closely related genera, are resp…
View article: Multi-locus sequence typing and phylogenetics of Cryptococcus neoformans AD hybrids
Multi-locus sequence typing and phylogenetics of Cryptococcus neoformans AD hybrids Open
View article: Therapeutic Use of the Antimicrobial Peptide PNR20 to Resolve Disseminated Candidiasis in a Murine Model
Therapeutic Use of the Antimicrobial Peptide PNR20 to Resolve Disseminated Candidiasis in a Murine Model Open
Invasive fungal infections (IFIs) caused by Candida species are an emerging threat globally, given that patients at-risk and antifungal resistance are increasing. Antimicrobial peptides (AMPs) have shown good therapeutic capacity against d…
View article: ANTIFUNGAL RESISTANCE: A GROWING CONCERN
ANTIFUNGAL RESISTANCE: A GROWING CONCERN Open
Globally, the increasing number of drug-resistant human pathogens represents a major threat to public health. Among these pathogens, fungi that have acquired resistance to the already scarce arsenal of antifungals are of particular signifi…
View article: In Vitro Antifungal Activity of Three Synthetic Peptides against Candida auris and Other Candida Species of Medical Importance
In Vitro Antifungal Activity of Three Synthetic Peptides against Candida auris and Other Candida Species of Medical Importance Open
Candidiasis is an opportunistic infection affecting immunosuppressed and hospitalized patients, with mortality rates approaching 40% in Colombia. The growing pharmacological resistance of Candida species and the emergence of multidrug-resi…
View article: Rare Yeasts in Latin America: Uncommon Yet Meaningful
Rare Yeasts in Latin America: Uncommon Yet Meaningful Open
Systemic infections caused by rare yeasts are increasing given the rise in immunocompromised or seriously ill patients. Even though globally, the clinical significance of these emerging opportunistic yeasts is increasingly being recognized…
View article: Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase
Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase Open
The fungal species Cryptococcus neoformans and C. gattii are human pathogens for which drug resistance or other treatment and management challenges exist. Here, we report differential susceptibility to azoles among both species, with some …
View article: Cm-p5 Peptide Dimers Inhibit Biofilms of Candida albicans Clinical Isolates, C. parapsilosis and Fluconazole-Resistant Mutants of C. auris
Cm-p5 Peptide Dimers Inhibit Biofilms of Candida albicans Clinical Isolates, C. parapsilosis and Fluconazole-Resistant Mutants of C. auris Open
Antimicrobial peptides (AMPs) represent a promising class of therapeutic biomolecules that show antimicrobial activity against a broad range of microorganisms, including life-threatening pathogens. In contrast to classic AMPs with membrane…
View article: Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species
Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species Open
Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, includin…
View article: Cryptococcus neoformans Causing Meningoencephalitis in Adults and a Child from Lima, Peru: Genotypic Diversity and Antifungal Susceptibility
Cryptococcus neoformans Causing Meningoencephalitis in Adults and a Child from Lima, Peru: Genotypic Diversity and Antifungal Susceptibility Open
Cryptococcosis, caused predominantly by Cryptococcus neoformans, is a potentially fatal, opportunistic infection that commonly affects the central nervous system of immunocompromised patients. Globally, this mycosis is responsible for almo…
View article: ¡Subestimadas y letales! Así son las infecciones invasivas por hongos
¡Subestimadas y letales! Así son las infecciones invasivas por hongos Open
En el reino de estos gérmenes existen alrededor de seis millones de especies, pero tres en particular afectan la salud humana al punto de convertirse en una amenaza para la salud pública y un duro desafío para tratamientos que salvarían vi…
View article: P124 <i>Cryptococcus neoformans</i>-and <i>Cryptococcus gattii</i>-specific antibodies vary among children and adults with cryptococcosis and healthy from Colombia
P124 <i>Cryptococcus neoformans</i>-and <i>Cryptococcus gattii</i>-specific antibodies vary among children and adults with cryptococcosis and healthy from Colombia Open
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Background Cryptococcus neoformans (Cn), predominantly, and Cryptococcus gattii (Cg) cause cryptococcosis, a life-threatening systemic mycosis of global distribution affecting mainly…
View article: S8.5d <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> clinical isolates from Colombia develop heteroresistance to fluconazole at high concentrations
S8.5d <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> clinical isolates from Colombia develop heteroresistance to fluconazole at high concentrations Open
S8.5 Genotyping of Cryptococcus neoformans and C. gattii, September 23, 2022, 3:00 PM - 4:30 PM Introduction Cryptococcosis is a worldwide mycosis caused by Cryptococcus neoformans and Cryptococcus gattii. Although resistance to antifungal…
View article: P002 Antifungal activity of antimicrobial synthetic peptides against <i>Candida</i> species of public health importance
P002 Antifungal activity of antimicrobial synthetic peptides against <i>Candida</i> species of public health importance Open
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Background Candidiasis is one of the most frequent opportunistic infections in immunosuppressed and/or hospitalized patients. In countries like Colombia, candidiasis is associated wi…
View article: P070 Antimicrobial peptides from the <i>Coleoptera</i> family <i>Scarabaeidae</i> against <i>Candida</i> and <i>Cryptococcus</i> pathogenic yeasts.
P070 Antimicrobial peptides from the <i>Coleoptera</i> family <i>Scarabaeidae</i> against <i>Candida</i> and <i>Cryptococcus</i> pathogenic yeasts. Open
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Host defense peptides (HDP) are produced by a diversity of beetles. The aims of this work were (1) to find new promising peptides from the Coleoptera family Scarabaeidae w…