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View article: Systems biology-driven miR-mRNA integration identifies potential steroid- refractoriness biomarkers in ulcerative colitis and reveals a conserved mechanism across species
Systems biology-driven miR-mRNA integration identifies potential steroid- refractoriness biomarkers in ulcerative colitis and reveals a conserved mechanism across species Open
Background and Aims: Approximately 60% of patients with ulcerative colitis (UC) exhibit steroid resistance or dependence, highlighting the need for reliable biomarkers to predict therapeutic response. This study employed a systems biology …
View article: Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles: A focus on inflammatory bowel disease
Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles: A focus on inflammatory bowel disease Open
Background Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) have emerged as key regulators of intercellular communication, orchestrating essential biological processes by delivering bioactive cargoes to target cells. Availabl…
View article: P074 Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells
P074 Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells Open
Background Crohn’s disease (CD) is characterised by expansion of mesenteric adipose tissue, called creeping fat, which seems to be directly related to disease activity. Adipose stem cells (ASCs) isolated from the creeping fat of CD patient…
View article: P168 Specialized pro-resolving lipid mediator Resolvin D1 and omega 6 dihomo-γ-linolenic acid are unable to solve inflammation in the creeping fat of patients with severe postoperative recurrence in Crohn's disease
P168 Specialized pro-resolving lipid mediator Resolvin D1 and omega 6 dihomo-γ-linolenic acid are unable to solve inflammation in the creeping fat of patients with severe postoperative recurrence in Crohn's disease Open
Background The ω3 derivate resolvin D1 (RvD1), and the ω6 dihomo-γ-linolenic acid (DGLA) prevent collateral damage by overcoming inflammation and enhancing microbial clearance. In Crohn's disease, the mesenteric adipose tissue becomes infl…
View article: P022 Development of a novel experimental model for studying creeping fat in Crohn's Disease
P022 Development of a novel experimental model for studying creeping fat in Crohn's Disease Open
Background A characteristic feature of Crohn's disease (CD) is the transformation of mesenteric adipose tissue into creeping fat (CrF), which becomes inflamed and surrounds the transmural lesion. The occurrence of this condition has been a…
View article: P1193 NOD2 and Beyond: Unmasking Tobacco-Induced Epigenetic Changes in Crohn's Disease
P1193 NOD2 and Beyond: Unmasking Tobacco-Induced Epigenetic Changes in Crohn's Disease Open
Background Smoking has been shown to have a very negative impact on Crohn's disease (CD). Indeed, this harmful habit induces the early onset of the disease and doubles the risk of postoperative recurrence. This research project involves a …
View article: P020 Effects of Anti-TNF Treatment on Browning of Mesenteric Adipose Tissue with Crohn's Disease
P020 Effects of Anti-TNF Treatment on Browning of Mesenteric Adipose Tissue with Crohn's Disease Open
Background Crohn's disease (CD) is characterized by the expansion of mesenteric fat, known as creeping fat (CrF), to the inflamed segments of the intestine. Our group observed that CrF showed a conversion to beige tissue, a phenomenon know…
View article: Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn’s Disease Patients through Epigenetic Changes
Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn’s Disease Patients through Epigenetic Changes Open
Patients with Crohn’s disease (CD) who smoke are known to have a worse prognosis than never-smokers and a higher risk for post-surgical recurrence, whereas patients who quit smoking after surgery have significantly lower post-operative rec…
View article: The Genetic Diversity and Dysfunctionality of Catalase Associated with a Worse Outcome in Crohn’s Disease
The Genetic Diversity and Dysfunctionality of Catalase Associated with a Worse Outcome in Crohn’s Disease Open
Chronic gut inflammation in Crohn’s disease (CD) is associated with an increase in oxidative stress and an imbalance of antioxidant enzymes. We have previously shown that catalase (CAT) activity is permanently inhibited by CD. The purpose …
View article: Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn’s Disease
Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn’s Disease Open
Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn’s disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of viscera…
View article: Glycogen accumulation in adipocyte precursors from elderly and obese subjects triggers inflammation via <scp>SIRT1</scp>/6 signaling
Glycogen accumulation in adipocyte precursors from elderly and obese subjects triggers inflammation via <span>SIRT1</span>/6 signaling Open
Dysfunctional adipocyte precursors have emerged as key determinants for obesity‐ and aging‐related inflammation, but the mechanistic basis remains poorly understood. Here, we explored the dysfunctional adipose tissue of elderly and obese i…
View article: The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn’s Disease
The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn’s Disease Open
Background and Aims Crohn’s disease [CD] is associated with complex microbe–host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms to surrounding adipose tissu…
View article: Mn(II) Complexes of Enlarged Scorpiand-Type Azamacrocycles as Mimetics of MnSOD Enzyme
Mn(II) Complexes of Enlarged Scorpiand-Type Azamacrocycles as Mimetics of MnSOD Enzyme Open
Living organisms depend on superoxide dismutase (SOD) enzymes to shield themselves from the deleterious effects of superoxide radical. In humans, alterations of these protective mechanisms have been linked to the pathogenesis of many disea…
View article: P083 An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activity
P083 An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s Disease patients with different clinical activity Open
Background Crohn’s disease (CD) is characterized by the expansion of mesenteric fat attached to the inflamed segments of the intestine, also known as “creeping fat” which seems to be directly related to disease activity. Our group revealed…
View article: P042 Succinate promotes the conversion from white to beige adipose tissue in Crohn’s Disease
P042 Succinate promotes the conversion from white to beige adipose tissue in Crohn’s Disease Open
Background Crohn’s disease (CD) is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Bacterial infiltration across this leaky gut facilitates access to the mesenteric fat and the develop…
View article: P001 Succinate, a gut microbiota-derived metabolite, modulates the inflammatory status of the creeping fat in Crohn’s disease
P001 Succinate, a gut microbiota-derived metabolite, modulates the inflammatory status of the creeping fat in Crohn’s disease Open
Background Crohn’s disease [CD] is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Recent works suggest that bacterial infiltration across this leaky gut facilitates access to the mese…
View article: P050 Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patients
P050 Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patients Open
Background Crohn’s disease (CD) is characterized by persistent inflammation and ulcerations at the small or large bowel, provoking chronic low-grade systemic inflammation. Adipose tissue (AT) is believed to play an active role in the patho…
View article: Crohn’s Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat
Crohn’s Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat Open
Our understanding of the interplay between human adipose tissue and the immune system is limited. The mesothelium, an immunologically active structure, emerged as a source of visceral adipose tissue. After investigating the mesothelial pro…
View article: Molecular Epidemiology Reveals Low Genetic Diversity among Cryptococcus neoformans Isolates from People Living with HIV in Lima, Peru, during the Pre-HAART Era
Molecular Epidemiology Reveals Low Genetic Diversity among Cryptococcus neoformans Isolates from People Living with HIV in Lima, Peru, during the Pre-HAART Era Open
Cryptococcosis, a mycosis presenting mostly as meningoencephalitis, affecting predominantly human immunodeficiency virus (HIV)-infected people, is mainly caused by Cryptococcus neoformans. The genetic variation of 48 C. neoformans isolates…
View article: Microbial Signature in Adipose Tissue of Crohn’s Disease Patients
Microbial Signature in Adipose Tissue of Crohn’s Disease Patients Open
Crohn’s disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be direc…
View article: Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern Open
Background Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-der…
View article: Additional file 1 of Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Additional file 1 of Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern Open
Additional file 1. Supplementary file 1.
View article: DOP84 Crohn’s disease modifies the DNA methylome of human adipose-stem cells, which is only partially re-established in remission
DOP84 Crohn’s disease modifies the DNA methylome of human adipose-stem cells, which is only partially re-established in remission Open
Background Crohn’s disease (CD) is characterised by the expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-tissue stem cells (hASCs) from CF exhibit a dysfunctional phenotype, in…
View article: Additional file 2 of Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Additional file 2 of Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern Open
Additional file 2. Supplementary file 2.
View article: Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring
Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring Open
Fetal programming has been proposed as a key mechanism underlying the association between intrauterine exposure to maternal diabetes and negative health outcomes in offspring. To determine whether gestational diabetes mellitus (GDM) might …
View article: SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity Open
View article: DOP05 Adipose-derived stem cells from Crohn’s disease patients show antigen presenting cell-like properties
DOP05 Adipose-derived stem cells from Crohn’s disease patients show antigen presenting cell-like properties Open
Under physiological conditions, mesenchymal stem cells (MSCs) are known to modulate the function of diverse types of immune cells, both adaptive and innate. However, only recently has their role in an inflammatory microenvironment undergon…
View article: Mesothelial Origin of Creeping Fat Progenitors in Crohn's Disease
Mesothelial Origin of Creeping Fat Progenitors in Crohn's Disease Open
View article: Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells
Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells Open
We identified a DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype of mature adipocytes.
View article: Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota Open
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and …