Caroline Addison Carvalho Xavier de Medeiros
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View article: Effectiveness of local Tocilizumab administration in mitigating alveolar bone loss and inflammation in experimental periodontitis
Effectiveness of local Tocilizumab administration in mitigating alveolar bone loss and inflammation in experimental periodontitis Open
To examine the impact of locally applied Tocilizumab (TCZ), an anti-interleukin-6 receptor antibody, on experimental periodontitis. 50 Wistar male rats were divided into three groups: (1) Healthy (n = 10), (2) Experimental Periodontitis (n…
View article: Mechanisms of photobiomodulation therapy in treating and preventing antineoplastic-induced oral mucositis: a systematic review
Mechanisms of photobiomodulation therapy in treating and preventing antineoplastic-induced oral mucositis: a systematic review Open
Purpose: To conduct a systematic review of the mechanisms of photobiomodulation therapy (PBMT) for treating or preventing oral mucositis (OM) caused by antineoplastic therapy. Methods: Following PRISMA 2020 guidelines, a search was conduct…
View article: Immobilization of Papain in Chitosan Membranes as a Potential Alternative for Skin Wounds
Immobilization of Papain in Chitosan Membranes as a Potential Alternative for Skin Wounds Open
Papain (an enzyme from the latex of Carica papaya) is an interesting natural bioactive macromolecule used as therapeutic alternative for wound healing due to debridement action in devitalized or necrotic tissues. However, its use in high d…
View article: Lacticaseibacillus casei decrease long-chain fatty acids and most substances in an experimental model of intestinal mucositis
Lacticaseibacillus casei decrease long-chain fatty acids and most substances in an experimental model of intestinal mucositis Open
L. casei prevented the mucosal damage associated with 5-FU-induced intestinal mucositis reduced long-chain fatty acid levels in the feces.
View article: The beneficial effects of Lacticaseibacillus casei on the small intestine and colon of Swiss mice against the deleterious effects of 5-fluorouracil
The beneficial effects of Lacticaseibacillus casei on the small intestine and colon of Swiss mice against the deleterious effects of 5-fluorouracil Open
Background Intestinal mucositis is one of the most common and important side effects of 5-fluorouracil (5-FU). Currently, there are still no specific and effective protocols for its prevention and treatment. The aim of the present study wa…
View article: Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters
Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters Open
Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C. longa on 5-fluorouracil (5-FU)-induce…
View article: Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters
Curcuma longa extract protects against 5-fluorouracil-induced oral mucositis in hamsters Open
Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C. longa on 5-fluorouracil (5-FU)-induce…
View article: Losartan improves intestinal mucositis induced by 5-fluorouracil in mice
Losartan improves intestinal mucositis induced by 5-fluorouracil in mice Open
View article: The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor
The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor Open
A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on p…
View article: Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders
Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders Open
Bovine colostrum is a rich source of nutrients and biologically active molecules known to be able to modulate the human immune system, such as lactoferrin, lysozyme, lactoperoxidase, immunoglobulins and growth factors. This comprehensive r…
View article: AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model
AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model Open
Background: The aim of this study was to evaluate the role of AT1 and AT2 receptors in a periodontal inflammation experimental model. Methods: Periodontal inflammation was induced by LPS/Porphyromonas gingivalis. Maxillae, femur, and verte…
View article: Effect of Dexamethasone-Loaded PLGA Nanoparticles on Oral Mucositis Induced by 5-Fluorouracil
Effect of Dexamethasone-Loaded PLGA Nanoparticles on Oral Mucositis Induced by 5-Fluorouracil Open
Oral mucositis (OM) is characterized by the presence of severe ulcers in the oral region that affects patients treated with chemotherapy. It occurs in almost all patients who receive radiotherapy of the head and neck, as well as patients w…
View article: <i>In vitro-in vivo</i> availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model
<i>In vitro-in vivo</i> availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model Open
The formulation modifies pharmacokinetics parameters such as apparent distribution volume and mean residence time. The PLGA + Met 10 mg/kg had a slower elimination rate compared to Met 100 mg/kg in diabetic rats in a periodontal disease ex…
View article: Effect of Gold Nanoparticle on 5-Fluorouracil-Induced Experimental Oral Mucositis in Hamsters
Effect of Gold Nanoparticle on 5-Fluorouracil-Induced Experimental Oral Mucositis in Hamsters Open
Background: Oral mucositis (OM) is a severe inflammation of the oral mucosal cells associated with chemotherapy and/or radiotherapy-induced toxicity, resulting in epithelial ulcers and higher risk of death from sepsis. The aim of the prese…
View article: Zirconia/hydroxyapatite (80/20) scaffold repair in critical size calvarial defect increased FGF-2, osteocalcin and OPG immunostaining and IL-10 levels.
Zirconia/hydroxyapatite (80/20) scaffold repair in critical size calvarial defect increased FGF-2, osteocalcin and OPG immunostaining and IL-10 levels. Open
The aim of this study was to characterize and evaluate zirconia/hydroxyapatite in a critical size calvarial defect model in rats. Zirconia/hydroxyapatite (80/20) scaffold was characterized by X-ray diffraction (XRD) and Scanning Electron M…
View article: Gliclazide Prevents 5-FU-Induced Oral Mucositis by Reducing Oxidative Stress, Inflammation, and P-Selectin Adhesion Molecules
Gliclazide Prevents 5-FU-Induced Oral Mucositis by Reducing Oxidative Stress, Inflammation, and P-Selectin Adhesion Molecules Open
Oral mucositis (OM) is one of the main side effects of the head and neck cancer treatment, particularly radiotherapy and/or chemotherapy. OM is characterized by ulcers, erythema, dysphagia, xerostomia, and increased susceptibility to oppor…
View article: Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats
Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats Open
View article: Chitosan Membrane Modified With a New Zinc(II)-Vanillin Complex Improves Skin Wound Healing in Diabetic Rats
Chitosan Membrane Modified With a New Zinc(II)-Vanillin Complex Improves Skin Wound Healing in Diabetic Rats Open
The treatment of chronic wounds is considered a public health problem. When the condition affects at-risk groups such as those with diabetics, it becomes a great clinical challenge. In this work, we evaluated the healing effects of a new z…
View article: Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats
Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats Open
Evidence shows that metformin is an antidiabetic drug, which can exert favorable anti-inflammatory effects and decreased bone loss. The development of nanoparticles for metformin might be useful for increased therapeutic efficacy. The aim …
View article: Telmisartan Modulates the Oral Mucositis Induced by 5-Fluorouracil in Hamsters
Telmisartan Modulates the Oral Mucositis Induced by 5-Fluorouracil in Hamsters Open
Oral mucositis (OM) is a common adverse effect resulting from cancer therapy. The OM it has implications that may compromise oncologic treatment and decrease the patient's quality of life. The therapeutic options to prevent or treat the sy…
View article: Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model
Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model Open
Background The aim of this study was to evaluate the effect of olmesartan medoxomil (Olme), an angiotensin II receptor antagonist, on oral mucositis ( OM ) experimental model. Methods Oral mucositis was induced in hamsters with 5‐fluoroura…
View article: Metformin Hydrochloride-Plga Nanoparticles in Diabetic Rats in A Periodontal Disease Experimental Model
Metformin Hydrochloride-Plga Nanoparticles in Diabetic Rats in A Periodontal Disease Experimental Model Open
The aim of this study was synthesize and evaluate the effects of Poly (D, L-Lactide-co-glycolide) (PLGA) Nanoparticles (NPs) of metformin (PLGA+ Met) on inflammation, and bone loss in a ligature-induced periodontitis rat model. The prepare…
View article: Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters
Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters Open
Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer ther…
View article: Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis
Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis Open
Metformin, at a concentration of 50 mg/kg, decreases the inflammatory response, oxidative stress and bone loss in ligature-induced periodontitis in rats.
View article: Quality of Life, Integrative Community Therapy, Family Support, and Satisfaction with Health Services Among Elderly Adults with and without Symptoms of Depression
Quality of Life, Integrative Community Therapy, Family Support, and Satisfaction with Health Services Among Elderly Adults with and without Symptoms of Depression Open
View article: Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats Open
The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knee…
View article: Azilsartan Reduced TNF-α and IL-1β Levels, Increased IL-10 Levels and Upregulated VEGF, FGF, KGF, and TGF-α in an Oral Mucositis Model
Azilsartan Reduced TNF-α and IL-1β Levels, Increased IL-10 Levels and Upregulated VEGF, FGF, KGF, and TGF-α in an Oral Mucositis Model Open
Oral mucositis (OM) is a common complication of treatments for head and neck cancer, particularly radiotherapy with or without chemotherapy. OM is characterised by oral erythema, ulceration, and pain. The aim of this study was to evaluate …