Explanipedia

Corrigendum to ‘Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection’ [Mol Metab Volume 99 (2025) Article 102194] Open

Caroline Bartman, Shengqi Hou, Fabian Correa, Yihui Shen, Victoria da Silva-Diz , et al. · 2025

Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection Open

Caroline Bartman, Shengqi Hou, Fabian Correa, Yihui Shen, Victoria da Silva-Diz , et al. · 2025

Abstract 1050 Measuring tumor metabolism in living mice Open

Caroline Bartman, Vineeth Vengayil · 2025

Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress Open

Michael Scaglione, Montana Knight, Krittin Trihemasava, Kelly Rome, Anne-Sophie Archambault , et al. · 2025

Summary / Abstract To maintain lineage-specific functions, cells must acquire and allocate nutrients across diverse cellular processes, even in metabolically-dysregulated environments. The mechanisms allowing CD8+ T cells to maintain immun…

Quantification of nutrient fluxes during acute exercise in mice Open

Jessie Axsom, Tara TeSlaa, Won Dong Lee, Qingwei Chu, Alexis J. Cowan , et al. · 2024

Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection Open

Caroline Bartman, Shengqi Hou, Fabian Correa, Yihui Shen, Victoria da Silva-Diz , et al. · 2024

Viral infection of cells leads to metabolic changes, but how viral infection changes whole-body and tissue metabolism in vivo has not been comprehensively studied. In particular, it is unknown how metabolism might be differentially affecte…

One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade Open

Xincheng Xu, Zihong Chen, Caroline Bartman, Xi Xing, Kellen Olszewski , et al. · 2024

Selected Ion Monitoring for Orbitrap-Based Metabolomics Open

Wenyun Lu, Matthew J. McBride, Won Dong Lee, Xi Xing, Xincheng Xu , et al. · 2024

Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for many metabolites, including low-concentration species, poor i…

Mitochondrial ATP generation is more proteome efficient than glycolysis Open

Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Zihong Chen, Caroline Bartman , et al. · 2024

Selected ion monitoring for orbitrap-based metabolomics Open

Wenyun Lu, Matthew J. McBride, Won Dong Lee, Xi Xing, Xincheng Xu , et al. · 2024

Orbitrap mass spectrometry in full scan mode enables simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet sensitivity remains limiting for many metabolites, including low concentration species, poor ionize…

Selected ion monitoring for orbitrap-based metabolomics Open

Wenyun Lu, Matthew J. McBride, Won Dong Lee, Xi Xing, Xincheng Xu , et al. · 2024

Orbitrap mass spectrometry in full scan mode enables simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet sensitivity remains limiting for many metabolites, including low concentration species, poor ionize…

One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade Open

Xincheng Xu, Zihong Chen, Caroline Bartman, Xi Xing, Kellen Olszewski , et al. · 2023

Summary Nucleotides perform important metabolic functions, carrying energy and feeding nucleic acid synthesis. Here, we use isotope tracing-mass spectrometry to quantitate the contributions to purine nucleotides of salvage versus de novo s…

Metabolic pathway analysis using stable isotopes in patients with cancer Open

Caroline Bartman, Brandon Faubert, Joshua D. Rabinowitz, Ralph J. DeBerardinis · 2023

Slow TCA flux and ATP production in primary solid tumours but not metastases Open

Caroline Bartman, Daniel Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han , et al. · 2023

Controllable genome editing with split-engineered base editors Open

Kiara N. Berríos, Niklaus H. Evitt, Rachel A. DeWeerd, Diqiu Ren, Meiqi Luo , et al. · 2021

Slow TCA flux implies low ATP production in tumors Open

Caroline Bartman, Yihui Shen, Won Dong Lee, Tara TeSlaa, Connor S.R. Jankowski , et al. · 2021

Summary The tricarboxylic acid (TCA) cycle oxidizes carbon substrates to carbon dioxide, with the resulting high energy electrons fed into the electron transport chain to produce ATP by oxidative phosphorylation. Healthy tissues derive mos…

Quantitative flux analysis in mammals Open

Caroline Bartman, Tara TeSlaa, Joshua D. Rabinowitz · 2021

The Source of Glycolytic Intermediates in Mammalian Tissues Open

Tara TeSlaa, Caroline Bartman, Connor S.R. Jankowski, Zhaoyue Zhang, Xincheng Xu , et al. · 2021

Quantitative Fluxomics of Circulating Metabolites Open

Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa , et al. · 2020

Quantitative fluxomics of circulating metabolites Open

Sheng Hui, Alexis J. Cowan, Xianfeng Zeng, Lifeng Yang, Tara TeSlaa , et al. · 2020

SUMMARY Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we devel…

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation Open

Caroline Bartman, Nicole Hamagami, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison , et al. · 2018

Transcriptional burst initiation and polymerase pause release are key control points of transcriptional regulation Open

Caroline Bartman, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel , et al. · 2018

Transcriptional regulation occurs via changes to the rates of various biochemical processes. Sequencing-based approaches that average together many cells have suggested that polymerase binding and polymerase release from promoter-proximal …

Design Principles of Mammalian Transcriptional Regulation Open

Caroline Bartman · 2018

Transcriptional regulation occurs via changes to different biochemical steps of transcription, but it remains unclear which steps are subject to change upon biological perturbation. Single cell studies have revealed that transcription occu…

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries Open

Sarah Hsu, Thomas G. Gilgenast, Caroline Bartman, Christopher R. Edwards, Aaron J. Stonestrom , et al. · 2017

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade Open

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec , et al. · 2016

Epigenetic profiling suggests that exhausted T cells are a distinct cell linage.

Impact of <i>Staphylococcus aureus</i> USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans Open

Maria‐Luisa Alegre, Luqiu Chen, Michael David, Caroline Bartman, Susan Boyle‐Vavra , et al. · 2016

Staphylococcus aureus is both a commensal and a pathogen, and USA300, a strain that is usually methicillin-resistant but can sometimes be methicillin-susceptible, has been causing skin and soft tissue infections (SSTIs) in epidemic proport…

The composition of the microbiota modulates allograft rejection Open

Yuk Man Lei, Luqiu Chen, Ying Wang, Andrew Stefka, Luciana Molinero , et al. · 2016

Transplantation is the only cure for end-stage organ failure, but without immunosuppression, T cells rapidly reject allografts. While genetic disparities between donor and recipient are major determinants of the kinetics of transplant reje…

A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition Open

Chris C.‐S. Hsiung, Caroline Bartman, Peng Huang, Paul Ginart, Aaron J. Stonestrom , et al. · 2016

During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosi…

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition Open

Chris C.‐S. Hsiung, Caroline Bartman, Peng Huang, Paul Ginart, Aaron J. Stonestrom , et al. · 2016

During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosi…

Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping Open

Caroline Bartman, Sarah Hsu, Chris C.‐S. Hsiung, Arjun Raj, Gerd A. Blobel · 2016

Caroline Bartman YOU? Author Swipe