Caroline Bonner
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View article: Standardized dynamic glucose testing reveals donor-dependent heterogeneity in human islet function
Standardized dynamic glucose testing reveals donor-dependent heterogeneity in human islet function Open
Glucose-stimulated insulin secretion (GSIS) testing of isolated islets of Langerhans is crucial for assessing β-cell function, yet protocol variability complicates result interpretation. This study investigated insulin secretion heterogene…
View article: Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODY
Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODY Open
Heterozygous mutations in HNF1A cause HNF1A-MODY, the most common form of monogenic diabetes, characterized by age-dependent onset and progression. Despite HNF1A's established role in beta cell function, the mechanisms underlying disease p…
View article: Metabolic State Determines Central and Peripheral Mechanisms of Liraglutide-Enhanced Insulin Secretion
Metabolic State Determines Central and Peripheral Mechanisms of Liraglutide-Enhanced Insulin Secretion Open
While liraglutide effectively treats type 2 diabetes (T2D) and obesity, its mechanism of action across disease progression remains poorly understood. Liraglutide selectively enhances GSIS in islets from glucose-intolerant donors and in isl…
View article: The role of the glucagon‐FGF21 axis in improving beta cell function during glucose intolerance and SGLT2 inhibition
The role of the glucagon‐FGF21 axis in improving beta cell function during glucose intolerance and SGLT2 inhibition Open
Objective Although primarily secreted by the liver, Fibroblast Growth Factor 21 (FGF21) is also expressed in the pancreas, where its function remains unclear. This study aims to elucidate the role of the glucagon‐FGF21 interaction in the m…
View article: Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study
Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study Open
In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin in…
View article: High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells
High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells Open
Using 13 C 6 glucose labeling coupled to GC-MS and 2D 1 H- 13 C HSQC NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell function. In both mouse and human islets, the contribution of glu…
View article: Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells
Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells Open
Rat insulinoma INS-1 cells are widely used to study insulin secretory mechanisms. Studies have shown that a population of INS-1 cells are bi-hormonal, co-expressing insulin, and proglucagon proteins. They coined this population as immature…
View article: Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets
Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets Open
Studies implicating sodium–glucose cotransporter 2 (SGLT2) inhibitors in glucagon secretion by pancreatic α-cells reported controversial results. We hypothesized that interindividual heterogeneity in SGLT2 expression and regulation may aff…
View article: 27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019
27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019 Open
International audience
View article: The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release
The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release Open
The newest classes of anti-diabetic agents include sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor (GLP1R) agonists. The SGLT2 inhibitor dapagliflozin reduces glucotoxicity by glycosuria but elevates …
View article: O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells
O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells Open
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells. TxNIP is a scaffold protein interacting with target proteins to inhibit or stimulate the…
View article: Gene expression profiling of molecular target genes which are regulated by hepatocyte nuclear factor 1 Alpha (HNF1A) in rat insulin-secreting cells: role in HNF1A-MODY
Gene expression profiling of molecular target genes which are regulated by hepatocyte nuclear factor 1 Alpha (HNF1A) in rat insulin-secreting cells: role in HNF1A-MODY Open
In this project, we were interested in studying HNF1A-induced defects in the expression of genes involved in the differentiation and regeneration of beta-cells in a cellular model of HNFlA-maturity-onset-diabetes-of-the-young(HNF1A-MODY), …
View article: 26th Annual Meeting of the European Group for the study of Insulin Resistance, Lille, France, 7–8th June 2018
26th Annual Meeting of the European Group for the study of Insulin Resistance, Lille, France, 7–8th June 2018 Open
International audience
View article: Single Low Dose of Human Recombinant Antithrombin (ATryn) has no Impact on Endotoxin-Induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study
Single Low Dose of Human Recombinant Antithrombin (ATryn) has no Impact on Endotoxin-Induced Disseminated Intravascular Coagulation: An Experimental Randomized Open Label Controlled Study Open
Background: Antithrombin (AT) III physiological levels are decreased during septic shock and supplementation therapy could therefore be beneficial. Objective: We hypothesized that the use of recombinant human AT could reduce disseminated i…
View article: Purity of islet preparations and 5-year metabolic outcome of allogenic islet transplantation
Purity of islet preparations and 5-year metabolic outcome of allogenic islet transplantation Open
In allogenic islet transplantation (IT), high purity of islet preparations and low contamination by nonislet cells are generally favored. The aim of the present study was to analyze the relation between the purity of transplanted preparati…
View article: Human pancreatic β cell lncRNAs control cell-specific regulatory networks
Human pancreatic β cell lncRNAs control cell-specific regulatory networks Open
Summary Recent studies have uncovered thousands of long non-coding RNAs (IncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type-specific, and exhibit dynamic regulation during differentiation or upon changing glucose conc…
View article: Human Recombinant Antithrombin (ATryn®) Administration Improves Survival and Prevents Intravascular Coagulation after Intraportal Islet Transplantation in a Piglet Model
Human Recombinant Antithrombin (ATryn®) Administration Improves Survival and Prevents Intravascular Coagulation after Intraportal Islet Transplantation in a Piglet Model Open
Human islet transplantation is a viable treatment option for type 1 diabetes mellitus (T1DM). However, pancreatic islet inflammation after transplantation induced by innate immune responses is likely to hinder graft function. This is media…