Caroline Brandes
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View article: CAR’TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment
CAR’TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment Open
Acute myeloid leukemia (AML), a fast-progressing hematological malignancy affecting myeloid cells, is typically treated with chemotherapy or hematopoietic stem cell transplantation. However, approximately half of the patients face relapses…
View article: Combining CSPG4-CAR and CD20-CCR for treatment of metastatic melanoma
Combining CSPG4-CAR and CD20-CCR for treatment of metastatic melanoma Open
The prognosis for patients with metastatic melanoma is poor and treatment options are limited. Genetically-engineered T cell therapy targeting chondroitin sulfate proteoglycan 4 (CSPG4), however, represents a promising treatment option, es…
View article: Automated, scaled, transposon-based production of CAR T cells
Automated, scaled, transposon-based production of CAR T cells Open
Background There is an increasing demand for chimeric antigen receptor (CAR) T cell products from patients and care givers. Here, we established an automated manufacturing process for CAR T cells on the CliniMACS Prodigy platform that is s…
View article: Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related <scp>mRNA</scp> s
Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related <span>mRNA</span> s Open
Learning is essential for survival and is controlled by complex molecular mechanisms including regulation of newly synthesized mRNAs that are required to modify synaptic functions. Despite the well-known role of RNA-binding proteins (RBPs)…