Christine Brun
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View article: <i>Drosophila melanogaster</i> miPEP8 regulates cell size through its interaction with ref(2)P/p62
<i>Drosophila melanogaster</i> miPEP8 regulates cell size through its interaction with ref(2)P/p62 Open
MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster , named miPEP8, which is involved in the regulation of wing siz…
View article: mimicINT: A workflow for microbe-host protein interaction inference
mimicINT: A workflow for microbe-host protein interaction inference Open
Background The increasing incidence of emerging infectious diseases is posing serious global threats. Therefore, there is a clear need for developing computational methods that can assist and speed up experimental research to better chara…
View article: mimicINT: A workflow for microbe-host protein interaction inference
mimicINT: A workflow for microbe-host protein interaction inference Open
Background The increasing incidence of emerging infectious diseases is posing serious global threats. Therefore, there is a clear need for developing computational methods that can assist and speed up experimental research to better chara…
View article: Clust&See3.0 : clustering, module exploration and annotation
Clust&See3.0 : clustering, module exploration and annotation Open
Background Cytoscape is an open-source software to visualize and analyze networks. However, large networks, such as protein interaction networks, are still difficult to analyze as a whole. Methods Here, we propose Clust&See3.0, a novel ver…
View article: Clust&See3.0 : clustering, module exploration and annotation
Clust&See3.0 : clustering, module exploration and annotation Open
Background Cytoscape is an open-source software to visualize and analyze networks. However, large networks, such as protein interaction networks, are still difficult to analyze as a whole. Methods Here, we propose Clust&See3.0, a novel ver…
View article: InteractORF, predictions of human sORF functions from an interactome study
InteractORF, predictions of human sORF functions from an interactome study Open
Short Open Reading Frames (sORFs) are ubiquitous genomic elements that have been overlooked for years, essentially due to their short length (< 100 residues) and the use of alternative start codons (other than AUG). However, some may encod…
View article: Principles of chromosome organization for meiotic recombination
Principles of chromosome organization for meiotic recombination Open
View article: Principles of chromosome organization for meiotic recombination
Principles of chromosome organization for meiotic recombination Open
SUMMARY In meiotic cells, chromosomes are organized as chromatin loop arrays anchored to a protein axis. This organization is essential to regulate meiotic recombination, from DNA double-strand break (DSB) formation to their repair 1 . In …
View article: A gut meta-interactome map reveals modulation of human immunity by microbiome effectors
A gut meta-interactome map reveals modulation of human immunity by microbiome effectors Open
SUMMARY The molecular mechanisms by which the gut microbiome influences human health remain largely unknown. Pseudomonadota is the third most abundant phylum in normal gut microbiomes. Several pathogens in this phylum can inject so-called …
View article: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks Open
View article: mimicINT demo files
mimicINT demo files Open
Demo files for mimicINT (a workflow for microbe-host protein interaction inference). Please check our preprint https://doi.org/10.1101/2022.11.04.515250 at and the documentation of the worflow at at https://github.com/TAGC-NetworkBiology/m…
View article: mimicINT demo files
mimicINT demo files Open
Demo files for mimicINT (a workflow for microbe-host protein interaction inference). Please check our preprint https://doi.org/10.1101/2022.11.04.515250 at and the documentation of the worflow at at https://github.com/TAGC-NetworkBiology/m…
View article: <i>mimic</i> INT: a workflow for microbe-host protein interaction inference
<i>mimic</i> INT: a workflow for microbe-host protein interaction inference Open
Background The increasing incidence of emerging infectious diseases is posing serious global threats. Therefore, there is a clear need for developing computational methods that can assist and speed up experimental research to better charac…
View article: Genetic architecture of natural variation of cardiac performance from flies to humans
Genetic architecture of natural variation of cardiac performance from flies to humans Open
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of t…
View article: Author response: Genetic architecture of natural variation of cardiac performance from flies to humans
Author response: Genetic architecture of natural variation of cardiac performance from flies to humans Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Deciphering the geneti…
View article: A proteome-scale map of the SARS-CoV-2–human contactome
A proteome-scale map of the SARS-CoV-2–human contactome Open
View article: Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests
Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests Open
Understanding the relationship between genetic variations and variations in complex and quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locu…
View article: In Depth Exploration of the Alternative Proteome of Drosophila melanogaster
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster Open
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their open readin…
View article: The Intricacy of the Viral-Human Protein Interaction Networks: Resources, Data, and Analyses
The Intricacy of the Viral-Human Protein Interaction Networks: Resources, Data, and Analyses Open
Viral infections are one of the major causes of human diseases that cause yearly millions of deaths and seriously threaten global health, as we have experienced with the COVID-19 pandemic. Numerous approaches have been adopted to understan…
View article: In depth exploration of the alternative proteome of <i>Drosophila melanogaster</i>
In depth exploration of the alternative proteome of <i>Drosophila melanogaster</i> Open
Recent studies have shown that hundreds of small proteins were occulted when protein coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their open readin…
View article: Discovery of potential functional paths by integration of phospho-proteomics data in the PPI network using a RWR framework
Discovery of potential functional paths by integration of phospho-proteomics data in the PPI network using a RWR framework Open
International audience
View article: Epi-MEIF, a flexible and efficient method for detection of high order epistatic interactions from complex phenotypic traits
Epi-MEIF, a flexible and efficient method for detection of high order epistatic interactions from complex phenotypic traits Open
Understanding the relationship between genetic variations and variations in complex and quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locu…
View article: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks Open
Meiosis requires the formation of programmed DNA double strand breaks (DSBs), essential for fertility and for generating genetic diversity. DSBs are induced by the catalytic activity of the TOPOVIL complex formed by SPO11 and TOPOVIBL. To …
View article: Genetic architecture of natural variation of cardiac performance: from flies to Humans
Genetic architecture of natural variation of cardiac performance: from flies to Humans Open
Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. We investigated the natural variation of cardiac performance in the sequenced inbred lines of t…
View article: Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer
Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer Open
The high mortality rate in septic shock patients is likely due to environmental and genetic factors, which influence the host response to infection. Two genome-wide association studies (GWAS) on 832 septic shock patients were performed. We…
View article: MetamORF: a repository of unique short open reading frames identified by both experimental and computational approaches for gene and metagene analyses
MetamORF: a repository of unique short open reading frames identified by both experimental and computational approaches for gene and metagene analyses Open
The development of high-throughput technologies revealed the existence of non-canonical short open reading frames (sORFs) on most eukaryotic ribonucleic acids. They are ubiquitous genetic elements conserved across species and suspected to …
View article: ArchiHeart - Dataset : Software containers, SQlite database and DGRP data
ArchiHeart - Dataset : Software containers, SQlite database and DGRP data Open
Title : Genetic architecture of natural variation of cardiac performance in flies Abstract : Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlyin…
View article: ArchiHeart - Dataset : Software containers, SQlite database and DGRP data
ArchiHeart - Dataset : Software containers, SQlite database and DGRP data Open
Title : Genetic architecture of natural variation of cardiac performance in flies Abstract : Deciphering the genetic architecture of human cardiac disorders is of fundamental importance but their underlyin…
View article: MetamORF: A repository of unique short Open Reading Frames identified by both experimental and computational approaches for gene-level and meta-analysis
MetamORF: A repository of unique short Open Reading Frames identified by both experimental and computational approaches for gene-level and meta-analysis Open
The development of high-throughput technologies revealed the existence of non-canonical short open reading frames (sORFs) on most eukaryotic RNAs. They are ubiquitous genetic elements highly conserved across species and suspected to be inv…
View article: The role of 3′UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization
The role of 3′UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization Open
Multifunctional proteins often perform their different functions when localized in different subcellular compartments. However, the mechanisms leading to their localization are largely unknown. Recently, 3′UTRs were found to regulate the c…