Caroline C. Picoli
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View article: SUN-671 The Gut-Bone Axis: The Role of X/A-like Cells in Skeletal Regulation
SUN-671 The Gut-Bone Axis: The Role of X/A-like Cells in Skeletal Regulation Open
Disclosure: C.D. Picoli: None. J.R. Aponte: None. T. Feng: None. P. Le: None. C.J. Rosen: None. Z. Li: None. Background: Bariatric surgery is the most effective treatment for severe obesity and type 2 diabetes but comes with side effects, …
View article: Entangled cellular and molecular relationships at the sensory neuron-cancer interface
Entangled cellular and molecular relationships at the sensory neuron-cancer interface Open
View article: Next-gen tools in cancer neuroscience
Next-gen tools in cancer neuroscience Open
The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innov…
View article: Estimating the replicability of Brazilian biomedical science
Estimating the replicability of Brazilian biomedical science Open
Concerns over the replicability and reproducibility of published research have grown in many research fields, but empirical data to inform policies are still scarce. Biomedical research in Brazil expanded rapidly over the last three decade…
View article: Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice
Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice Open
Comparative studies of surgical and pharmaceutical approaches to weight loss offer critical insights that can guide clinical decision-making for managing obesity. VSG and semaglutide exhibit comparable efficacy in promoting weight reductio…
View article: Pericytes as the Orchestrators of Vasculature and Adipogenesis
Pericytes as the Orchestrators of Vasculature and Adipogenesis Open
Pericytes (PCs) are located surrounding the walls of small blood vessels, particularly capillaries and microvessels. In addition to their functions in maintaining vascular integrity, participating in angiogenesis, and regulating blood flow…
View article: Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression Open
Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by…
View article: Sympathetic nerve-adipocyte interactions in response to acute stress
Sympathetic nerve-adipocyte interactions in response to acute stress Open
View article: Hematopoietic stem cell stretches and moves in its bone marrow niche
Hematopoietic stem cell stretches and moves in its bone marrow niche Open
View article: Sensory nerves in the spotlight of the stem cell niche
Sensory nerves in the spotlight of the stem cell niche Open
Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells throug…
View article: Ablation of sensory nerves favours melanoma progression
Ablation of sensory nerves favours melanoma progression Open
The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment…
View article: Resistance exercise training induces subcutaneous and visceral adipose tissue browning in Swiss mice
Resistance exercise training induces subcutaneous and visceral adipose tissue browning in Swiss mice Open
Aerobic exercise training (AER) induces the browning of white adipose tissue, turning adipocytes multilocular, highly vascularized and expressing uncoupling protein 1 (UCP-1). The current study compared the efficiency of resistance to aero…
View article: Table of Contents
Table of Contents Open
View article: Pericytes Act as Key Players in Spinal Cord Injury
Pericytes Act as Key Players in Spinal Cord Injury Open
View article: Behavior of adipocytes in the mammary niche during pregnancy and lactation
Behavior of adipocytes in the mammary niche during pregnancy and lactation Open
Primarily, the adipose tissue is known for its function storing excess energy as fat. This tissue is also an endocrine organ and communicates with several tissues, such as muscle, liver and brain. In addition, the adipose tissue is an acce…
View article: Neural stem cell niche heterogeneity
Neural stem cell niche heterogeneity Open
View article: Peak Velocity as an Alternative Method for Training Prescription in Mice
Peak Velocity as an Alternative Method for Training Prescription in Mice Open
Purpose: To compare the efficiency of an aerobic physical training program prescribed according to either velocity associated with maximum oxygen uptake (vVO2max) or peak running speed obtained during an incremental tread…
View article: Methyl jasmonate: a phytohormone with potential for the treatment of inflammatory bowel diseases
Methyl jasmonate: a phytohormone with potential for the treatment of inflammatory bowel diseases Open
Objectives The phytohormone methyl jasmonate (MeJA) has been identified as a vital cell regulator in plants. This substance is analogous to eicosanoids and similar to that of anti-inflammatory prostaglandins. In animals and in animal cells…