Caroline E. Thorselius
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View article: Development of a Norway Rat Hepacivirus Reporter for High-Throughput Quantification of Neutralising Antibodies
Development of a Norway Rat Hepacivirus Reporter for High-Throughput Quantification of Neutralising Antibodies Open
Hepatitis C virus (HCV) remains a major global health challenge, with vaccine research hindered by lack of immunocompetent animal models. Infection with the HCV-related Norway rat hepacivirus 1 (NrHV) in rats or mice shares HCV defining ch…
View article: In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus
In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus Open
The lack of immunocompetent animal models severely impedes the development of vaccines against hepatitis C virus (HCV) and researchers have therefore explored the application of surrogate virus models. Norway rat hepacivirus 1 (NrHV) is a …
View article: Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus Open
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C v…
View article: Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV Open
Background and Aims Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining c…