Caroline Holtkamp
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View article: Congenital infection with Plasmodium malariae: a rare case of intrauterine transmission in Germany
Congenital infection with Plasmodium malariae: a rare case of intrauterine transmission in Germany Open
Background Malaria remains the leading parasitic disease worldwide with a significant global morbidity and mortality burden. Plasmodium malariae , the least prevalent of the five Plasmodium species that cause human malaria, has unique char…
View article: Congenital Infection with Plasmodium malariae - A Rare Case of Intrauterine Transmission in Germany
Congenital Infection with Plasmodium malariae - A Rare Case of Intrauterine Transmission in Germany Open
Background: Malaria remains the leading parasitic disease worldwide with a significant global morbidity and mortality burden. Plasmodium malariae, the least prevalent of the five Plasmodium species that cause human malaria, has unique char…
View article: Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI
Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI Open
Knowledge regarding the sustainability of immune responses after COVID-19 vaccination is important, e.g., to decide whom and when to booster. Thus, we analyzed antibody titers in firefighters six months after vaccination with the mRNA-base…
View article: Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?
Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? Open
Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to inter…
View article: Acquired aplastic anemia following <scp>SARS‐CoV</scp>‐2 vaccination
Acquired aplastic anemia following <span>SARS‐CoV</span>‐2 vaccination Open
COVID‐19 is a potential life‐threatening viral disease caused by SARS‐CoV‐2 and was declared a pandemic by the WHO in March 2020. mRNA‐based SARS‐CoV‐2 vaccines are routinely recommended in immune‐compromised patients, including patients w…
View article: The Course of Anti-HBc Antibodies over Time in Immunocompromised Hosts
The Course of Anti-HBc Antibodies over Time in Immunocompromised Hosts Open
Hepatitis B virus infection results in the appearance of anti-HBc antibodies that normally persist lifelong. We analyzed the course of anti-HBc antibodies overtime, focusing on patients with a permanent loss or fluctuating anti-HBc antibod…
View article: Performance of the LIAISON® SARS-CoV-2 Antigen Assay vs. SARS-CoV-2-RT-PCR
Performance of the LIAISON® SARS-CoV-2 Antigen Assay vs. SARS-CoV-2-RT-PCR Open
We aimed to evaluate the LIAISON® SARS-CoV-2 antigen assay (DiaSorin), comparing its performance to real-time polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2 RNA. 182 (110 PCR-positive and 72 PCR-negative) nasopharyngeal…
View article: Fast Detection of SARS-CoV-2 RNA Directly from Respiratory Samples Using a Loop-Mediated Isothermal Amplification (LAMP) Test
Fast Detection of SARS-CoV-2 RNA Directly from Respiratory Samples Using a Loop-Mediated Isothermal Amplification (LAMP) Test Open
The availability of simple SARS-CoV-2 detection methods is crucial to contain the COVID-19 pandemic. This study examined whether a commercial LAMP assay can reliably detect SARS-CoV-2 genomes directly in respiratory samples without having …
View article: Fast Detection of SARS-CoV-2 RNA Directly from Respiratory Samples Using a Loop-Mediated Isothermal Amplification (LAMP) Test
Fast Detection of SARS-CoV-2 RNA Directly from Respiratory Samples Using a Loop-Mediated Isothermal Amplification (LAMP) Test Open
The availability of simple SARS-CoV-2 detection methods is crucial to contain the COVID-19 pandemic. This study examined whether a commercial LAMP assay can reliably detect SARS-CoV-2 genomes directly in respiratory samples without having …
View article: LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response
LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response Open
Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we…
View article: A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes
A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes Open
BACKGROUND: Propofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile. However, propofol could have long term effects on neuronal cells and is associated with post-operative delirium (POD). In t…