Caroline J. Bax
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View article: Performance of non‐invasive prenatal testing in vanishing‐twin and multiple pregnancies: results of <scp>TRIDENT</scp>‐2 study
Performance of non‐invasive prenatal testing in vanishing‐twin and multiple pregnancies: results of <span>TRIDENT</span>‐2 study Open
Objective To evaluate the performance of non‐invasive prenatal testing (NIPT) in vanishing‐twin and multiple pregnancies. Methods This study was conducted as part of the TRIDENT‐2 study, in which NIPT was offered as a first‐tier screening …
View article: Maternity care providers’ perspectives on late-term gestation management (LATE-study): A cross-sectional survey
Maternity care providers’ perspectives on late-term gestation management (LATE-study): A cross-sectional survey Open
Objective To examine the experiences, perspectives, and impact on daily work of maternity care providers regarding the updated Dutch national guideline on the management of late-term pregnancies. Design and setting This was a cross-section…
View article: Preferences of pregnant women and obstetric healthcare professionals on using noninvasive prenatal testing to predict adverse pregnancy outcomes: a discrete choice experiment
Preferences of pregnant women and obstetric healthcare professionals on using noninvasive prenatal testing to predict adverse pregnancy outcomes: a discrete choice experiment Open
Objectives Noninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available to pregnant women worldwide. In the future, the scope of NIPT could potentially be expanded to the p…
View article: First‐Trimester Prediction Models Based on Maternal Characteristics for Adverse Pregnancy Outcomes: A Systematic Review and Meta‐Analysis
First‐Trimester Prediction Models Based on Maternal Characteristics for Adverse Pregnancy Outcomes: A Systematic Review and Meta‐Analysis Open
Background Early risk stratification can facilitate timely interventions for adverse pregnancy outcomes, including preeclampsia (PE), small‐for‐gestational‐age neonates (SGA), spontaneous preterm birth (sPTB) and gestational diabetes melli…
View article: Fetal Fraction of Cell‐Free <scp>DNA</scp> in the Prediction of Adverse Pregnancy Outcomes: A Nationwide Retrospective Cohort Study
Fetal Fraction of Cell‐Free <span>DNA</span> in the Prediction of Adverse Pregnancy Outcomes: A Nationwide Retrospective Cohort Study Open
Objective To assess the added value of fetal fraction of cell‐free DNA in the maternal circulation in the prediction of adverse pregnancy outcomes. Design Retrospective cohort study. Setting Nationwide implementation study on non‐invasive …
View article: Perspectives of pregnant women on broadening the scope of noninvasive prenatal testing from screening for foetal aneuploidies to prediction of adverse pregnancy outcomes: A qualitative study
Perspectives of pregnant women on broadening the scope of noninvasive prenatal testing from screening for foetal aneuploidies to prediction of adverse pregnancy outcomes: A qualitative study Open
Objective To explore the perspectives of pregnant women on broadening the scope of noninvasive prenatal testing (NIPT) from screening for foetal aneuploidies to prediction of adverse pregnancy outcomes. Methods Four online focus groups ( n…
View article: Lenti-viral overexpression of RhoGEF Trio reduces CD8 T cell extravasation into atherosclerotic vein graft lesions in mice
Lenti-viral overexpression of RhoGEF Trio reduces CD8 T cell extravasation into atherosclerotic vein graft lesions in mice Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Rembrandt Institute for Cardiovascular Sciences Background In advanced atherosclerotic plaques, such as vein graft lesions, n…
View article: Fetal fraction of cell-free DNA in noninvasive prenatal testing and adverse pregnancy outcomes: a nationwide retrospective cohort study of 56,110 pregnant women
Fetal fraction of cell-free DNA in noninvasive prenatal testing and adverse pregnancy outcomes: a nationwide retrospective cohort study of 56,110 pregnant women Open
In early pregnancy, a low fetal fraction is associated with increased risk of adverse pregnancy outcomes. These findings can be used to expand the potential of noninvasive prenatal testing in the future, enabling the prediction of pregnanc…
View article: Non‐invasive prenatal testing (NIPT) in twin pregnancies affected by early single fetal demise: A systematic review of NIPT and vanishing twins
Non‐invasive prenatal testing (NIPT) in twin pregnancies affected by early single fetal demise: A systematic review of NIPT and vanishing twins Open
The screening performance of non‐invasive prenatal testing (NIPT) in vanishing twin (VT) pregnancies is relatively unknown. To close this knowledge gap, we conducted a systematic review of the available literature. Studies describing the t…
View article: Fetal Fraction of Cell-Free DNA in Non-Invasive Prenatal Testing and Adverse Pregnancy Outcomes: A Nationwide Retrospective Cohort Study of 56 110 Pregnant Women Participating in the TRIDENT-2 Study
Fetal Fraction of Cell-Free DNA in Non-Invasive Prenatal Testing and Adverse Pregnancy Outcomes: A Nationwide Retrospective Cohort Study of 56 110 Pregnant Women Participating in the TRIDENT-2 Study Open
View article: Clinical impact of additional findings detected by genome-wide non-invasive prenatal testing: Follow-up results of the TRIDENT-2 study
Clinical impact of additional findings detected by genome-wide non-invasive prenatal testing: Follow-up results of the TRIDENT-2 study Open
(The American Journal of Human Genetics 109, 1140–1152; June 2, 2022) In the originally published version of this article, in Table 3, the column heading “Placenta biopsies” was placed erroneously under “Available clinical follow-up” inste…
View article: Clinical impact of additional findings detected by genome-wide non-invasive prenatal testing: Follow-up results of the TRIDENT-2 study
Clinical impact of additional findings detected by genome-wide non-invasive prenatal testing: Follow-up results of the TRIDENT-2 study Open
View article: Nationwide implementation of the non-invasive prenatal test: Evaluation of a blended learning program for counselors
Nationwide implementation of the non-invasive prenatal test: Evaluation of a blended learning program for counselors Open
This study assesses the results of a mandatory blended learning-program for counselors (e.g. midwives, sonographers, obstetricians) guiding national implementation of the Non-Invasive Prenatal Test (NIPT). We assessed counselors’ 1) knowle…
View article: Low fetal fraction in cell‐free DNA testing is associated with adverse pregnancy outcome: Analysis of a subcohort of the TRIDENT‐2 study
Low fetal fraction in cell‐free DNA testing is associated with adverse pregnancy outcome: Analysis of a subcohort of the TRIDENT‐2 study Open
Objectives To assess the association between low fetal fraction (FF) in prenatal cell‐free DNA (cfDNA) testing and adverse pregnancy outcomes. Methods We conducted a retrospective cohort study of participants of the TRIDENT‐2 study (Dutch …
View article: Association between low fetal fraction in cell‐free DNA testing and adverse pregnancy outcome: A systematic review
Association between low fetal fraction in cell‐free DNA testing and adverse pregnancy outcome: A systematic review Open
Objective Low fetal fraction (LFF) in prenatal cell‐free DNA (cfDNA) testing is an important cause of test failure and no‐call results. LFF might reflect early abnormal placentation and therefore be associated with adverse pregnancy outcom…
View article: Can Previous Associations of Single Nucleotide Polymorphisms in the TLR2, NOD1, CXCR5, and IL10 Genes in the Susceptibility to and Severity of Chlamydia trachomatis Infections Be Confirmed?
Can Previous Associations of Single Nucleotide Polymorphisms in the TLR2, NOD1, CXCR5, and IL10 Genes in the Susceptibility to and Severity of Chlamydia trachomatis Infections Be Confirmed? Open
Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differen…
View article: Temporizing management vs immediate delivery in early‐onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open‐label randomized controlled trial
Temporizing management vs immediate delivery in early‐onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open‐label randomized controlled trial Open
Introduction There is little evidence to guide the timing of delivery of women with early‐onset severe preeclampsia. We hypothesize that immediate delivery is not inferior for neonatal outcome but reduces maternal complications compared wi…
View article: Authors' reply re: Cerebroplacental ratio in predicting adverse perinatal outcome: a meta‐analysis of individual participant data
Authors' reply re: Cerebroplacental ratio in predicting adverse perinatal outcome: a meta‐analysis of individual participant data Open
View article: TRIDENT-2: National Implementation of Genome-wide Non-invasive Prenatal Testing as a First-Tier Screening Test in the Netherlands
TRIDENT-2: National Implementation of Genome-wide Non-invasive Prenatal Testing as a First-Tier Screening Test in the Netherlands Open
View article: Prediction model of postnatal renal function in fetuses with lower urinary tract obstruction (LUTO)—Development and internal validation
Prediction model of postnatal renal function in fetuses with lower urinary tract obstruction (LUTO)—Development and internal validation Open
Objective To develop a prediction model of postnatal renal function in fetuses with lower urinary tract obstruction (LUTO) based on fetal ultrasound parameters and amniotic fluid volume. Methods Retrospective nationwide cohort study of fet…
View article: Data for: Publication bias among prognostic accuracy studies of middle cerebral artery Doppler ultrasound
Data for: Publication bias among prognostic accuracy studies of middle cerebral artery Doppler ultrasound Open
1. Complete research dataset 2. List with excluded conference abstracts 3. List with excluded full text articles
View article: Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo‐aortic root dilatation
Transposition of the great arteries: Fetal pulmonary valve growth and postoperative neo‐aortic root dilatation Open
Objectives Documentation of semilunar valve growth in fetal transposition of the great arteries (TGA) and the relationship between neo‐aortic root (NAoR) dilatation, a cause for postoperative reinterventions after the arterial switch opera…
View article: Development of Nationwide Recommendations to Support Prenatal Counseling in Extreme Prematurity
Development of Nationwide Recommendations to Support Prenatal Counseling in Extreme Prematurity Open
OBJECTIVES: To develop a nationwide, evidence-based framework to support prenatal counseling in extreme prematurity, focusing on organization, decision-making, content, and style aspects. METHODS: A nationwide multicenter RAND–modified Del…
View article: Women’s experiences of monitoring the small-for-gestational age fetus by ultrasound: A qualitative study
Women’s experiences of monitoring the small-for-gestational age fetus by ultrasound: A qualitative study Open
In general, women in this study were satisfied with the ultrasounds for their small-for-gestational age pregnancies. However, women expressed a need for additional information to help cope with a feeling of uncertainty regarding cause and …
View article: Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes
Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes Open
OBJECTIVE: To assess the effectiveness of amnioinfusion in women with second-trimester preterm prelabor rupture of membranes. METHODS: We performed a nationwide, multicenter, open-label, randomized controlled trial, the PPROM: Expectant Ma…
View article: An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial); a randomised controlled trial
An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial); a randomised controlled trial Open
From an economic perspective, there is no preferential pain treatment in labouring intermediate to high risk women. Since patient controlled remifentanil is not equivalent to epidural analgesia with respect to AUC for satisfaction with pai…
View article: Cost-effectiveness of Diagnostic Testing Strategies Including Cervical-Length Measurement and Fibronectin Testing in Women With Symptoms of Preterm Labor
Cost-effectiveness of Diagnostic Testing Strategies Including Cervical-Length Measurement and Fibronectin Testing in Women With Symptoms of Preterm Labor Open
(Abstracted from Ultrasound Obstet Gynecol 2018;51:596–603) In this study, the authors sought to evaluate the cost-effectiveness of combining cervical length (CL) measurement and fetal fibronectin (fFN) testing in women with symptoms of pr…
View article: Fetal megacystis: a lot more than LUTO
Fetal megacystis: a lot more than LUTO Open
Objective Fetal megacystis presents a challenge in terms of counseling and management because of its varied etiology and evolution. The aim of this study was to present a comprehensive overview of the underlying etiologies and structural a…
View article: Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy
Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy Open
Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneou…
View article: Prenatal diagnosis of LUTO: improving diagnostic accuracy
Prenatal diagnosis of LUTO: improving diagnostic accuracy Open
Objective To propose a clinical score for the optimal antenatal diagnosis of fetal lower urinary tract obstruction (LUTO) in the second and third trimesters of pregnancy, as an alternative to the commonly used ultrasound triad of megacysti…