Explanipedia

ATGChallenge : un atelier de découverte et d’initiation à la bio-informatique Open

Marie Verneret, Caroline Leroux, Jocelyn Turpin, Riocreux-Verney Benjamin · 2025

L’ATGChallenge est un atelier pédagogique conçu pour initier les participants à la bio-informatique dans un contexte de virologie moléculaire, tout en les familiarisant avec les grandes étapes de la démarche scientifique.

A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats Open

Marie Verneret, Caroline Leroux, Thomas Faraut, Vincent Navratil, Emmanuelle Lerat , et al. · 2025

Association between genetic clades and cancer prevalence suggested by French-wide study of oncogenic small ruminant β-retrovirus diversity Open

Benjamin Riocreux-Verney, Marie Verneret, Rémi Diesler, Christine Dolmazon, Barbara Gineys , et al. · 2024

Introduction ENTV (Enzootic Nasal Tumor Virus) and JSRV (Jaagsiekte Sheep Retrovirus) are β-retroviruses responsible for respiratory cancers in sheep and goats. In this study, we analyzed the genetic features of the sheep and goat β-Retrov…

A genome-wide study of ruminants reveals two endogenous retrovirus families still active in goats Open

Marie Verneret, Caroline Leroux, Thomas Faraut, Vincent Navratil, Emmanuelle Lerat , et al. · 2024

Background: Endogenous retroviruses (ERV) are traces of ancestral retroviral germline infections that constitute a significant portion of mammalian genomes and function as LTR-retrotransposons. ERVs remain understudied in ruminants and usu…

Functional decline, long term symptoms and course of frailty at 3-months follow-up in COVID-19 older survivors, a prospective observational cohort study Open

Simon Prampart, Sylvain Le Gentil, Marie Laure Bureau, Claire Macchi, Caroline Leroux , et al. · 2022

Milk proteins as a feed restriction signature indicating the metabolic adaptation of dairy cows Open

Antoine Leduc, Sandrine Le Guillou, Leonardo Bianchi, Lydie Oliveira Correia, M. Gelé , et al. · 2022

Milk production in dairy cows is affected by numerous factors, including diet. Feed restriction is known to have little impact on milk total protein content but its effect on the fine protein composition is still poorly documented. The obj…

Tuberous sclerosis complex for the pulmonologist Open

Yasmine Rebaine, Mouhamad Nasser, Barbara Girerd, Caroline Leroux, Vincent Cottin · 2021

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder affecting almost all organs with no sex predominance. TSC has an autosomal-dominant inheritance and is caused by a heterozygous mutation in either the TSC1 or TSC2 gen…

Garantie de troupeau en matière de CAEV Open

Caroline Leroux · 2021

First case of nasal transitional carcinoma in a goat infected with Enzootic Nasal Tumor Virus in Belgium Open

A. Delaude, Els Raes, Caroline Leroux, Koen Chiers, L Sonck · 2020

An eleven-year-old, female goat was presented for evaluation of breathing difficulties and epistaxis. Radiographs and computed tomographic (CT) examination of the head revealed the presence of a space-occupying lesion involving the right n…

First case of nasal transitional carcinoma in a goat infected with Enzootic Nasal Tumor Virus in Belgium Open

A. Delaude, Els Raes, Caroline Leroux, Koen Chiers, L Sonck · 2020

An eleven-year-old, female goat was presented for evaluation of breathing difficulties and epistaxis. Radiographs and computed tomographic (CT) examination of the head revealed the presence of a space-occupying lesion involving the right n…

Evidence of jaagsiekte sheep retrovirus-induced pulmonary adenocarcinoma in Ouled Djellal breed sheep in Algeria. Open

Nour El Houda Belalmi, Nassim Sid, Omar Bennoune, Ouhida Soraya, M. De las Heras , et al. · 2020

We report the occurrence of lung cancer in a six months old lamb of Ouled Djellal breed from Algeria. The main clinical sign was a considerable amount of whitish foamy fluid discharge from the nostrils when the animal head was lowered and …

equine infectious anaemia Open

Caroline Leroux, Jean‐Luc Cadoré · 2019

This datasheet on equine infectious anaemia covers Identity, Overview, Associated Diseases, Pests or Pathogens, Distribution, Further Information.

Remodeling of the Actin Network Associated with the Non-Structural Protein 1 (NS1) of West Nile Virus and Formation of NS1-Containing Tunneling Nanotubes Open

Wilhelm Furnon, Pascal Fender, Marie-Pierre Confort, Sophie Desloire, Sawitree Nangola , et al. · 2019

The cellular response to the recombinant NS1 protein of West Nile virus (NS1WNV) was studied using three different cell types: Vero E6 simian epithelial cells, SH-SY5Y human neuroblastoma cells, and U-87MG human astrocytoma cells. Cells we…

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas Open

Jean‐Michel Maury, Claire Merveilleux du Vignaux, Gabrielle Drevet, Virginie Zarza, Lara Chalabreysse , et al. · 2019

The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported a positive effect of mTOR inhibitors in disease …

Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration Open

Nader Chebib, Fabienne Archer, Alexandra Bobet-Erny, Caroline Leroux, Vincent Cottin · 2018

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas Open

Jean‐Michel Maury, Claire Merveilleux du Vignaux, Gabrielle Drevet, Virginie Zarza, Lara Chalabreysse , et al. · 2018

The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PI3K/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II study reported a positive effect of mTOR inhibitors in disease control…

First case report of enzootic nasal adenocarcinoma in "Ouled Djellal" ewe in Algeria Open

Nassim Sid, Nour El Houda Belalmi, Louiza Benhamza, Soraya Ouhida, Mohammed Ezine Zebiri , et al. · 2018

We report clinical and pathological features of enzootic nasal adenocarcinoma (ENA) in one sheep in Algeria. A one-year-old Ouled Djellal sheep from a large herd (~1240 animals), located in Bordj Bou Arreridj, Algeria, was clinically diagn…

Blocked expression of key genes of the angiogenic pathway in JSRV-induced pulmonary adenocarcinomas Open

Maryline Gomes, Fabienne Archer, Nicolas Girard, Barbara Gineys, Christine Dolmazon , et al. · 2017

JSRV (Jaagsiekte Sheep Retrovirus) is a retrovirus inducing a transmissible lung adenocarcinoma in sheep and goats with predominantly lepidic and papillary lesions. This naturally occurring lung cancer in large animals shares many features…

Characterization of a novel canine T-cell line established from a spontaneously occurring aggressive T-cell lymphoma with large granular cell morphology Open

C. Bonnefont, C. Fournel‐Fleury, Frédérique Ponce, Sara Belluco, Dorothée Watrelot , et al. · 2015

Dogs with lymphoma are established as good model for human non-Hodgkin lymphoma studies. Canine cell lines derived from lymphomas may be valuable tools for testing new therapeutic drugs. In this context, we established a canine T-cell line…

Equine infectious anaemia in Europe: Time to re‐examine the efficacy of monitoring and control protocols? Open

Pompei Bolfă, Florica Bărbuceanu, S.‐E. Leau, Caroline Leroux · 2015

Equine infectious anaemia (EIA) is a disease with an almost worldwide distribution and is of considerable importance to the equine industry, primarily because it is one of only 11 notifiable equine specific diseases listed by the World Org…

Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein Open

Margaux Monot, Alexandra Erny, Barbara Gineys, Sophie Desloire, Christine Dolmazon , et al. · 2015

Ovine pulmonary adenocarcinoma is a naturally occurring lung cancer in sheep induced by the Jaagsiekte sheep retrovirus (JSRV). Its envelope glycoprotein (Env) carries oncogenic properties, and its expression is sufficient to induce in vit…

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