Caroline M. Li
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View article: Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma Open
Purpose Transcription-replication conflicts (TRCs) are a major source of endogenous replication stress in cancer. We previously discovered that pancreatic ductal adenocarcinoma (PDAC) demonstrates uniquely high levels of TRCs compared to o…
View article: Novel Peptide Therapeutic Approaches for Cancer Treatment
Novel Peptide Therapeutic Approaches for Cancer Treatment Open
Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the dir…
View article: Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis
Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis Open
We describe a gentle and rapid method to purify the intact multiprotein DNA replication complex using free flow electrophoresis (FFE). In particular, we applied FFE to purify the human cell DNA synthesome, which is a multiprotein complex t…