Caroline Picard
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View article: High Seroreactivities to Orthoebolaviruses in Rural Cameroon: A Case-Control Study on Nonhuman Primate Bites and a Cross-sectional Survey in Rural Populations
High Seroreactivities to Orthoebolaviruses in Rural Cameroon: A Case-Control Study on Nonhuman Primate Bites and a Cross-sectional Survey in Rural Populations Open
Background Ebola (EBOV) and Sudan (SUDV) orthoebolaviruses are responsible for lethal hemorrhagic fever outbreaks in humans in Central and West Africa, and in apes that can be at the source of human outbreaks for EBOV. Methods To assess th…
View article: Impact of the H274Y Substitution on N1, N4, N5, and N8 Neuraminidase Enzymatic Properties and Expression in Reverse Genetic Influenza A Viruses
Impact of the H274Y Substitution on N1, N4, N5, and N8 Neuraminidase Enzymatic Properties and Expression in Reverse Genetic Influenza A Viruses Open
The H274Y substitution (N2 numbering) in neuraminidase (NA) N1 confers oseltamivir resistance to A(H1N1) influenza viruses. This resistance has been associated with reduced N1 expression using transfected cells, but the effect of this subs…
View article: Detection of Crimean–Congo haemorrhagic fever virus in Hyalomma marginatum ticks, southern France, May 2022 and April 2023
Detection of Crimean–Congo haemorrhagic fever virus in Hyalomma marginatum ticks, southern France, May 2022 and April 2023 Open
Crimean–Congo haemorrhagic fever (CCHF), a potentially severe zoonotic viral disease causing fever and haemorrhagic manifestations in humans. As the Crimean–Congo haemorrhagic fever virus (CCHFV) has been detected in ticks in Spain and ant…
View article: Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model
Hemostasis defects underlying the hemorrhagic syndrome caused by mammarenaviruses in a cynomolgus macaque model Open
Viral hemorrhagic fevers (HF) are a group of acute febrile diseases with high mortality rates. Although hemostatic dysfunction appears to be a major determinant of the severity of the disease, it is still unclear what pathogenic mechanisms…
View article: A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates
A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates Open
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVA…
View article: Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys
Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys Open
The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two out…
View article: Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys
Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys Open
The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two out…
View article: A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains
A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains Open
A single-dose vaccine confers cross-protection and long-term efficacy against Lassa virus in cynomolgus monkeys.
View article: Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques
Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques Open
Lassa virus (LASV) is endemic in West Africa and induces a viral hemorrhagic fever (VHF) with up to 30% lethality among clinical cases. The mechanisms involved in control of Lassa fever or, in contrast, the ensuing catastrophic illness and…
View article: Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus
Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus Open
We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnos…
View article: Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus
Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus Open
We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnos…
View article: Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015
Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015 Open
Lassa fever has not been reported in Côte d'Ivoire. We performed a retrospective analysis of human serum samples collected in Côte d'Ivoire in the dry seasons (January-April) during 2015-2018. We identified a fatal human case of Lassa feve…
View article: <i>Arenaviridae</i> exoribonuclease presents genomic RNA edition capacity
<i>Arenaviridae</i> exoribonuclease presents genomic RNA edition capacity Open
The Arenaviridae is a large family of viruses causing both acute and persistent infections and causing significant public health concerns in afflicted regions. A “trademark” of infection is the quick and efficient immuno-suppression mediat…
View article: One-shot immunization using a Measles/Lassa vaccine fully protects cynomolgus monkeys against Lassa fever
One-shot immunization using a Measles/Lassa vaccine fully protects cynomolgus monkeys against Lassa fever Open
Purpose: Lassa fever is a major public health issue in Western Africa and there is still no licensed vaccine. Here we have used the Measles virus (MeV) vaccine platform to generate Lassa fever vaccine candidates expressing the Lassa virus …
View article: Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells
Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells Open
Lassa virus (LASV) is responsible for a viral hemorrhagic fever in humans and the death of 3,000 to 5,000 people every year. The immune response to LASV is poorly understood, but type I interferon (IFN-I) and T-cell responses appear to be …
View article: Evolution of influenza genome diversity during infection in immunocompetent patients
Evolution of influenza genome diversity during infection in immunocompetent patients Open
Introduction Minor frequency viruses play many important roles during viral infection that cannot be explained by the consensus sequence alone. In influenza, immunosuppressed individuals appear to generate numerous viral variants, leading …
View article: Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation sequencing workflow
Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation sequencing workflow Open
Background In recent years, metagenomic Next-Generation Sequencing (mNGS) has increasingly been used for an accurate assumption-free virological diagnosis. However, the systematic workflow evaluation on clinical respiratory samples and imp…
View article: A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins
A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins Open
Several Old World and New World arenaviruses are responsible for severe endemic and epidemic hemorrhagic fevers, whereas other members of the Arenaviridae family are nonpathogenic. To date, no approved vaccines, antivirals, or specific tre…
View article: Impact on antiviral resistance of E119V, I222L and R292K substitutions in influenza A viruses bearing a group 2 neuraminidase (N2, N3, N6, N7 and N9)
Impact on antiviral resistance of E119V, I222L and R292K substitutions in influenza A viruses bearing a group 2 neuraminidase (N2, N3, N6, N7 and N9) Open
NA-R292K and E119V + I222L substitutions conferred reduced inhibition by oseltamivir for all group 2 NAs. Surveillance of NA inhibitor resistance for zoonotic and human influenza viruses and the development of novel antiviral agents with d…