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View article: A novel intron variant is associated with emerging pfdhps mutant haplotypes in West and Central African Plasmodium falciparum
A novel intron variant is associated with emerging pfdhps mutant haplotypes in West and Central African Plasmodium falciparum Open
Sulfadoxine-pyrimethamine plays a key role in Plasmodium falciparum chemoprevention across Africa, yet the protective efficacy of SP is undermined by mutations conferring resistance in the genes encoding dihydrofolate reductase (pfdhfr) an…
View article: Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention
Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention Open
Sulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase ( dhps ) gene (437 G /540 E /581 G ) associated with sulfad…
View article: Asymptomatic Plasmodium falciparum infections and determinants of carriage in a seasonal malaria chemoprevention setting in Northern Cameroon and south Senegal (Kedougou)
Asymptomatic Plasmodium falciparum infections and determinants of carriage in a seasonal malaria chemoprevention setting in Northern Cameroon and south Senegal (Kedougou) Open
Background Among the several strategies recommended for the fight against malaria, seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine combination (SPAQ) targets children 3 months to 5 years in Sahel regio…
View article: Parasite clearance and protection from Plasmodium falciparum infection (PCPI): a two-arm, parallel, double-blinded, placebo-controlled, randomised trial of presumptive sulfadoxine-pyrimethamine versus artesunate monotherapy among asymptomatic children 3-5 years of age in Zambia
Parasite clearance and protection from Plasmodium falciparum infection (PCPI): a two-arm, parallel, double-blinded, placebo-controlled, randomised trial of presumptive sulfadoxine-pyrimethamine versus artesunate monotherapy among asymptomatic children 3-5 years of age in Zambia Open
Background: The 2022 malaria chemoprevention guidelines of the World Health Organization (WHO) recommend the provision of a full treatment course of an antimalarial medicine at predefined intervals, regardless of whether the child is infec…
View article: Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology
Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology Open
Background Recently revised WHO guidelines on malaria chemoprevention have opened the door to more tailored implementation. Countries face choices on whether to replace old drugs, target additional age groups, and adapt delivery schedules …
View article: Identification of the PfK13 mutations R561H and P441L in the Democratic Republic of Congo
Identification of the PfK13 mutations R561H and P441L in the Democratic Republic of Congo Open
R561H and P441L observed in eastern DRC are a concern, as they are associated with delayed artemisinin-based combination therapies-clearance and candidate marker of resistance, respectively. This is consistent with previous observations of…
View article: Identification of Single-Nucleotide Polymorphisms in the Mitochondrial Genome and Kelch 13 Gene of Plasmodium falciparum in Different Geographical Populations
Identification of Single-Nucleotide Polymorphisms in the Mitochondrial Genome and Kelch 13 Gene of Plasmodium falciparum in Different Geographical Populations Open
The emergence of artemisinin-resistant Plasmodium falciparum parasites in Southeast Asia threatens malaria control and elimination. The interconnectedness of parasite populations may be essential to monitor the spread of resistance. Combin…
View article: Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure
Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure Open
The genomic diversity of Plasmodium malariae malaria parasites is understudied, partly because infected individuals tend to present with low parasite densities, leading to difficulties in obtaining sufficient parasite DNA for genome analys…
View article: A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria
A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria Open
Although Plasmodium vivax parasites are the predominant cause of malaria outside of sub-Saharan Africa, they not always prioritised by elimination programmes. P. vivax is resilient and poses challenges through its ability to re-emerge from…
View article: Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges
Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges Open
Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies. This is especially true since resistance to the currently recommended artemisinins and partner drugs has been conf…
View article: World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria
World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria Open
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their…
View article: Emerging implications of policies on malaria treatment: genetic changes in the <i>Pfmdr-1</i> gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa
Emerging implications of policies on malaria treatment: genetic changes in the <i>Pfmdr-1</i> gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa Open
Artemether–lumefantrine (AL) and artesunate–amodiaquine (AS-AQ) are the most commonly used artemisinin-based combination therapies (ACT) for treatment of Plasmodium falciparum in Africa. Both treatments remain efficacious, but single nucle…
View article: Molecular assays for antimalarial drug resistance surveillance: A target product profile
Molecular assays for antimalarial drug resistance surveillance: A target product profile Open
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with a…
View article: A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line
A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line Open
Plasmodium knowlesi, a common parasite of macaques, is recognised as a significant cause of human malaria in Malaysia. The P. knowlesi A1H1 line has been adapted to continuous culture in human erythrocytes, successfully providing an in vit…
View article: Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations Open
The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing. Parasites infecting humans originate from genetically distinct subpopulations associated with the long-tailed (Mac…
View article: Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure
Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure Open
This study has shown that genomic diversity that lies within and between P. vivax populations can be used to elucidate potential drug resistance and invasion mechanisms, as well as facilitate the molecular barcoding of the parasite for sur…