Caroline Sabin
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View article: Polypharmacy in <scp>HIV</scp> : Rethinking what counts and why it matters
Polypharmacy in <span>HIV</span> : Rethinking what counts and why it matters Open
Polypharmacy, the concurrent use of multiple medications, presents a growing challenge in HIV care as people living with HIV age and experience earlier onset of age‐related co‐morbidities. However, how polypharmacy is defined and assessed …
View article: Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom
Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom Open
Background Integrase strand transfer inhibitors (INSTIs) are the mainstay of antiretroviral therapy (ART) globally. Virological breakthrough is uncommon but often manifests as low-level viremia, and only 50% of cases have identified drug r…
View article: People living with <scp>HIV</scp> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls
People living with <span>HIV</span> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls Open
Objectives Alterations in lipids and apolipoproteins contribute to cardiovascular disease (CVD) and are common in people with HIV. The aim of our study was to compare lipid profiles and body composition between people with and without HIV …
View article: Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV
Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV Open
Despite suppressive anti-retroviral therapy (ART), some older people with HIV show adverse ageing phenotypes, and the underlying mechanisms remain incompletely understood. We recruited 30 men with HIV aged ≥ 50 years and 15 well-matched me…
View article: Intersecting social determinants of health, multimorbidity and quality of life in people of Black ethnicities with HIV in South London
Intersecting social determinants of health, multimorbidity and quality of life in people of Black ethnicities with HIV in South London Open
Background: Social determinants of health (SDoH) impact health outcomes and rarely exert their influence in isolation. We examined associations between SDoH patterns, multimorbidity and quality of life (QoL) in people of Black ethnicities …
View article: Understanding hepatitis C virus reinfections in England in the context of eliminating viral hepatitis as a public health concern
Understanding hepatitis C virus reinfections in England in the context of eliminating viral hepatitis as a public health concern Open
HCV reinfection appeared to decrease over the study period, but people were most at risk in the year post-treatment, which remained constant over time. Harm reduction services should be accessible to people who inject drugs and people who …
View article: Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT
Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT Open
Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a d…
View article: Changes in characteristics and <scp>HIV</scp>‐clinical outcomes of pregnant people living with <scp>HIV</scp> in the <scp>UK</scp>
Changes in characteristics and <span>HIV</span>‐clinical outcomes of pregnant people living with <span>HIV</span> in the <span>UK</span> Open
Objective In this study, we explore changes in the demographic and clinical characteristics of pregnant people living with HIV, and their post‐partum HIV outcomes between 2000 and 2018. Methods We described pregnancies resulting in a live …
View article: Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period
Changes in multimorbidity burden and their impact on patient and healthcare outcomes in people with HIV over a 3–5-year period Open
Background: Despite increasing multimorbidity among people with HIV, its impact on health outcomes over time remains uncertain. We explored how distinct multimorbidity patterns affect a broad range of health outcomes over a 3–5-year period…
View article: Risk of Cancer in People With Human Immunodeficiency Virus Experiencing Varying Degrees of Immune Recovery With Sustained Virological Suppression on Antiretroviral Treatment for More Than 2 Years: An International, Multicenter, Observational Cohort
Risk of Cancer in People With Human Immunodeficiency Virus Experiencing Varying Degrees of Immune Recovery With Sustained Virological Suppression on Antiretroviral Treatment for More Than 2 Years: An International, Multicenter, Observational Cohort Open
Background The impact of long-term virological suppression (VS) and CD4 count recovery on non–AIDS-defining cancers (NADCs) is unclear. We determined whether poor immune recovery was associated with incident cancer risk in people with huma…
View article: Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV
Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV Open
Objectives: There is no consensus definition for multimorbidity. We explored how different frameworks affect multimorbidity patterns and their associations with patient-reported outcomes using the prospective, observational Pharmacokinetic…
View article: Predicted dolutegravir resistance in people living with HIV in South Africa during 2020–35: a modelling study
Predicted dolutegravir resistance in people living with HIV in South Africa during 2020–35: a modelling study Open
View article: Statement on the Importance of Sexuality and Gender Research
Statement on the Importance of Sexuality and Gender Research Open
View article: Direct-acting antiviral treatment outcomes in people infected with endemic compared to epidemic hepatitis C virus subtypes in England
Direct-acting antiviral treatment outcomes in people infected with endemic compared to epidemic hepatitis C virus subtypes in England Open
This study provides further evidence that endemic HCV subtypes lead to sub-optimal DAA efficacy, which may impact global HCV elimination.
View article: Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus
Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus Open
Background Inflammation and innate immune activation are associated with chronic human immunodeficiency virus (HIV) infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, their rela…
View article: Leukocyte Count in Solid Organ Transplant Recipients After SARS-CoV-2 mRNA Vaccination and Infection
Leukocyte Count in Solid Organ Transplant Recipients After SARS-CoV-2 mRNA Vaccination and Infection Open
Background: Solid organ transplant (SOT) recipients are at risk of severe COVID-19. Vaccination is an important preventive measure but may have side effects, including decreased leukocyte counts. We aimed to describe the prevalence and rel…
View article: Evidence for circulation of high-virulence HIV-1 subtype B variants in the United Kingdom
Evidence for circulation of high-virulence HIV-1 subtype B variants in the United Kingdom Open
The evolution of HIV-1 virulence has significant implications for epidemic control. Recent phylogenomic analyses identified low-prevalence HIV-1 variants exhibiting significant differences in disease progression. We analysed 40 888 partial…
View article: HIV prevention and missed opportunities among people with recently acquired HIV infection: Α protocol for a systematic review
HIV prevention and missed opportunities among people with recently acquired HIV infection: Α protocol for a systematic review Open
Background Individuals who have recently acquired HIV represent a unique population because the time frame since HIV acquisition is relatively short and identification of missed HIV prevention opportunities is, therefore, closer to real ti…
View article: Exploring the cascade of mental healthcare among people with <scp>HIV</scp> experiencing depressive symptoms in the UK and Ireland: The <scp>POPPY</scp> study
Exploring the cascade of mental healthcare among people with <span>HIV</span> experiencing depressive symptoms in the UK and Ireland: The <span>POPPY</span> study Open
Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People…
View article: HIV, the gut microbiome and clinical outcomes, a systematic review
HIV, the gut microbiome and clinical outcomes, a systematic review Open
Background Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation an…
View article: Psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV
Psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV Open
Objective: To investigate whether psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV. Design: Cross-sectional study of 273 participants (178 persons with HIV) from …
View article: The relationship between psychosocial factors and cognitive test performance in a South African cohort
The relationship between psychosocial factors and cognitive test performance in a South African cohort Open
Background Accurate assessment of cognitive impairment in low‐income settings may require consideration of complex psychosocial variables (PV). Failure to consider the association of PV with biological factors, such as HIV, could lead to f…
View article: Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV
Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV Open
Background: We aimed to provide insights into the effects of comorbidities on sleep health in people with HIV by assessing associations between multimorbidity patterns and sleep outcomes in the Pharmacokinetic and clinical Observations in …
View article: Comparing short‐term mortality between people with and without <scp>HIV</scp> admitted to the intensive care unit: A single‐centre matched cohort study (2000–2019)
Comparing short‐term mortality between people with and without <span>HIV</span> admitted to the intensive care unit: A single‐centre matched cohort study (2000–2019) Open
Objectives The survival rate of people with HIV admitted to intensive care units (ICUs) is approaching that of people without HIV. We conducted a matched‐cohort study of people with and without HIV admitted to ICU at a large hospital to co…
View article: Qualitative exploration of the barriers and facilitators to community pharmacy PrEP delivery for UK pharmacists and underserved community members using the COM-B model of behaviour change
Qualitative exploration of the barriers and facilitators to community pharmacy PrEP delivery for UK pharmacists and underserved community members using the COM-B model of behaviour change Open
Objectives Expanding delivery of oral pre-exposure prophylaxis (PrEP) to community pharmacies could improve access, aligning well with the UK government’s goals to eliminate new HIV acquisitions by 2030. Using the Capability, Opportunity, …
View article: HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015
HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015 Open
Introduction HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). Methods We in…
View article: The Camden and Islington Viral Hepatitis Identification Tool (<scp>CIVHIT</scp>): Use of a Clinical Database Case‐Finding Tool for Hepatitis B, Hepatitis C and <scp>HIV</scp> in Primary Care
The Camden and Islington Viral Hepatitis Identification Tool (<span>CIVHIT</span>): Use of a Clinical Database Case‐Finding Tool for Hepatitis B, Hepatitis C and <span>HIV</span> in Primary Care Open
Despite the availability of effective treatment and vaccines for hepatitis B virus (HBV) and C virus (HCV), many people are still infected and remain unaware of their infection. The Camden and Islington Viral Hepatitis Identification Tool …
View article: Corrigendum to “Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV” [Kidney International Reports Volume 7, Issue 4, April 2022, Pages 786-796]
Corrigendum to “Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV” [Kidney International Reports Volume 7, Issue 4, April 2022, Pages 786-796] Open
[This corrects the article DOI: 10.1016/j.ekir.2022.01.1054.].
View article: Results from a retrospective case finding and re-engagement exercise for people previously diagnosed with hepatitis C virus to increase uptake of directly acting antiviral treatment
Results from a retrospective case finding and re-engagement exercise for people previously diagnosed with hepatitis C virus to increase uptake of directly acting antiviral treatment Open
Background Direct acting antivirals (DAAs) for the Hepatitis C virus (HCV) have shifted the World Health Organisation global strategic focus to the elimination of HCV by 2030. In England, the UK Health Security Agency (UKHSA) led a nationa…
View article: A qualitative exploration of pharmacists and customers barriers and facilitators to community pharmacy PrEP delivery using the COM-B model of behaviour change
A qualitative exploration of pharmacists and customers barriers and facilitators to community pharmacy PrEP delivery using the COM-B model of behaviour change Open
Objectives Expanding delivery of oral Pre-exposure Prophylaxis (PrEP) to community pharmacies could improve access, aligning well with government goals for England to eliminate new HIV acquisitions by 2030. Using the Capability, Opportunit…