Caroline Stanton
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View article: Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal
Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal Open
The NF-κB family of transcription factor complexes are central regulators of inflammation, and their dysregulation contributes to the pathology of multiple inflammatory disease conditions. Accordingly, identifying pharmacological mechanism…
View article: Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity Open
SUMMARY The NLRP3 inflammasome is a protein complex that promotes pro-inflammatory signaling as part of the innate immune response. Hyperactivation of the NLRP3 inflammasome has been implicated in many inflammatory and neurodegenerative di…
View article: The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome
The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome Open
The NLRP3 inflammasome promotes inflammation in disease, yet the full repertoire of mechanisms regulating its activity is not well delineated. Among established regulatory mechanisms, covalent modification of NLRP3 has emerged as a common …
View article: The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome
The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome Open
Summary The NLRP3 inflammasome promotes inflammation in disease, yet the full repertoire of mechanisms regulating its activity are not well delineated. Among established regulatory mechanisms, covalent modification of NLRP3 has emerged as …
View article: Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly Open
The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines, including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory disorders. Howev…
View article: Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation Open
The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro‐inflammatory cytokines such as IL‐1β. Hyperactiv…
View article: Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation Open
SUMMARY The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro-inflammatory cytokines such as IL-1β. Hy…
View article: Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly
Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly Open
The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory disorders. Howeve…
View article: Succinylation of a KEAP1 sensor lysine promotes NRF2 activation
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation Open
Summary Crosstalk between metabolism and stress-responsive signaling is essential to maintaining cellular homeostasis. One way this crosstalk is achieved is through the covalent modification of proteins by endogenous, reactive metabolites …
View article: S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling Open
KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the presence of electrophilic agents by modification of i…
View article: Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2 Open
The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer's disease. At high extracellular concentrations, glutamate causes neuronal damage by promot…
View article: IreK-Mediated, Cell Wall-Protective Phosphorylation in <i>Enterococcus faecalis</i>
IreK-Mediated, Cell Wall-Protective Phosphorylation in <i>Enterococcus faecalis</i> Open
Enterococcus faecalis is a Gram-positive bacterium that is a major cause of hospital-acquired infections due, in part, to its intrinsic resistance to cell wall-active antimicrobials. One critical determinant of this resistance is the trans…